Pyridazine CAS 289-80-5 Purity> 99.0% (GC) Factory

Pyridazine (CAS: 289-80-5), yomwe nthawi zina imatchedwa 1,2-diazine, ndi mphete ya mamembala asanu ndi limodzi yomwe ili ndi maatomu awiri a nayitrogeni oyandikana.Pyridazine ndi mawonekedwe amwayi mu chemistry yamankhwala ndipo angagwiritsidwe ntchito ngati isosteric m'malo mwa phenyl kapena heteroaromatic mphete.Pyridazines amatha kusintha mawonekedwe a physiochemical a mamolekyu a mankhwala powonjezera kusungunuka kwawo kwa madzi, kutenga nawo gawo ngati olandila ma hydrogen bond, komanso kukhala ndi kuthekera kwakukulu kovutira ndi zolinga chifukwa cha mphindi yawo ya dipole.Pyridazine imapereka bioavailability, makamaka ku CNS, ndipo imatha kuchepetsa kawopsedwe.Pyridazine ndi gawo la mamolekyu angapo a mankhwala, ndipo pharmacophore ya pyradzine yachititsa kuti pakhale mitundu yosiyanasiyana ya mankhwala.Pyridazine amatanthauza heterocyclic azine pawiri okhala nayitrogeni hexaheterocyclic , izo ndi pyrimidine, pyrazine ndi isomers wina ndi mzake.Pyridazine amagwiritsidwa ntchito kwambiri ngati mankhwala opangira mankhwala, monga sulfa SMP ya nthawi yayitali yomwe imachokera ku pyridazine, 4-amino-cinnoline yomwe ili ya antimalarials, kuthamanga kwa magazi mankhwala hydralazine, etc. onse amagwiritsa ntchito pyridazine ngati zipangizo;itha kugwiritsidwanso ntchito ngati zopangira mankhwala ophera tizilombo, popanga mankhwala ophera udzu, "herbicide-sensitive", "Milstem", "bromine herbicide-sensitive".Pyridazines ndi mankhwala a heterocyclic okhala ndi NN chomangira mu mphete yawo.Molekyu ya pyridazine ndi π-deficiehetermatic compound yofanana ndi pyridine.Chifukwa cha kukhalapo kwa ma heterocycle onunkhira a nayitrogeni a π awa amasungunuka mosavuta m'madzi poyerekeza ndi ma hydrocarbon ena.Dongosolo la mphete lonunkhira la pyridazine lili ndi maatomu awiri oyandikana nayitrogeni.Mphete ya pyridazine imapezeka mu mankhwala ophera udzu ambiri monga credazine, pyridatol ndi mankhwala ambiri monga cefozopran, olaparib, talazoparib, ndi cadralazine.