(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem ndi Darifenacin hydrobromide Yapakatikati
Kupereka kwa opanga;Kuyera Kwambiri ndi Mtengo Wopikisana
Malingaliro a kampani Shanghai Ruifu Chemical Co., Ltd.
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S) -3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Pakati pa Panipenem (CAS 87726-17-8) ndi Darifenacin hydrobromide (CAS 133099-07-7)
| Dzina la Chemical | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Mawu ofanana ndi mawu | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Nambala ya CAS | 104706-47-0 |
| Nambala ya CAT | Chithunzi cha RF-CC102 |
| Kuyera / Kusanthula Njira | ≥98.0% (GC) |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | C4H10ClNO |
| Kulemera kwa Maselo | 123.58 |
| Melting Point | 107.0 ~ 111.0 °C |
| Kusungunuka mu Madzi | Pafupifupi Transparency |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Woyera-Woyera mpaka Pale Brown Crystalline Ufa |
| Kuyera / Kusanthula Njira | ≥99.7% (GC) |
| Chiral Purity | ≥99.7% ee |
| Zotsalira pa Ignition | ≤0.50% |
| Kuzungulira Kwachindunji [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Chidetso Chilichonse Chamunthu | ≤0.20% |
| Zonyansa zonse | ≤0.30% |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | Pharmaceutical Intermediates;Chiral Compounds |
Njira Yowunika
Zida: Chida cha GC (Shimadzu GC-2010)
Mzere: DB-17 Agilent 30mX0.53mmX1.0μm
Kutentha koyambirira kwa uvuni: 80 ℃
Nthawi yoyamba 2.0min
Mulingo wa 15 ℃/min
Kutentha komaliza kwa uvuni: 250 ℃
Nthawi yomaliza 20min
Mpweya wonyamula nayitrogeni
Mode Constant flow
Kuthamanga kwa 5.0mL / min
Kugawanika kwa chiŵerengero cha 10: 1
Kutentha kwa jekeseni: 250 ℃
Kutentha kwa detector: 300 ℃
jekeseni voliyumu 1.0μL
Njira zodzitetezera musanaunike:
1. Condition column pa 240 ℃ kwa osachepera 30minutes.
2. Tsukani syringe ndi kuyeretsa jekeseni wa jekeseni bwino kuti muchotse zonyansa zomwe munasanthula poyamba.
3. Tsukani, pukutani ndi kudzaza madzi osungunuka mu syringe m'mbale.
Kukonzekera kwa Diluent:
Konzani 2% w/v sodium hydroxide solution m'madzi.
Kukonzekera kokhazikika:
Yesani pafupifupi 100mg ya (R) -3-hydroxyprrolidine hydrochloride muyezo mu vial, kuwonjezera 1mL ya diluent ndi kusungunula.
Kukonzekera mayeso:
Yesani pafupifupi 100mg ya mayeso oyesa mu vial, onjezani 1mL ya diluent ndi kusungunula.Konzekerani mobwereza.
Kachitidwe:
Jekeseni wopanda kanthu (wosungunula), kukonzekera kokhazikika ndi kukonzekera mayeso pogwiritsa ntchito mikhalidwe yomwe ili pamwamba pa GC.Samalani nsonga chifukwa chosowa kanthu.Nthawi yosungira pachimake chifukwa cha (R) -3-hydroxyprrolidine ndi pafupifupi 5.0min.
Zindikirani:
Nenani zotsatira ngati avareji
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
Shanghai Ruifu Chemical Co., Ltd. ndiwopanga komanso ogulitsa (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) yokhala ndi mawonekedwe apamwamba kwambiri, omwe amagwiritsidwa ntchito kwambiri popanga organic synthesis, kaphatikizidwe ka mankhwala apakati. ndi kaphatikizidwe ka Active Pharmaceutical Ingredient (API).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) ndi yapakatikati mwa kaphatikizidwe ka Panipenem (CAS 87726-17-8) ndi Darifenacin hydrobromide (CAS 133099-07-7).
(R) - (-) -3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) ndi chiral hydroxy yochokera ku pyrrlodine yomwe imagwiritsidwa ntchito popanga mankhwala a chiral niologically active monga muscarinic receptor antagonists ndi antimicrobial agents.
Njira ya kaphatikizidwe (R) -3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile adachita ndi trimethyl chlorosilane mu dichloromethane zosungunulira kuti apeze (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine ndiye hydrogenated pa Pd / C chothandizira. (R) -3-trimethylsiloxyepyrrolidine anapezedwa ndi sodium hydroxide mphete kutseka mankhwala.Pomaliza, (R) -3-hydroxypyrrolidine hydrochloride mankhwala anapezedwa ndi concentrated hydrochloric acid mankhwala ndi trimethylsilyl gulu zoteteza anachotsedwa.
