(R)-Lansoprazole Dexlansoprazole CAS 138530-94-6 Assay 98.0~102.0% (HPLC) Factory
Ruifu Chemical Supply Lansoprazole Intermediates
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(R)-Lansoprazole Dexlansoprazole CAS 138530-94-6
Dzina la Chemical | (R) - Lansoprazole |
Mawu ofanana ndi mawu | R-(+)-Lansoprazole;Dexlansoprazole;2 - [(R)-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl] -1H-benzimidazole;T 168390;TAK 390;Lansoprazole Chidetso 14;Zowonongeka Zogwirizana ndi Dexlansoprazole 2;(R) -2 - [[[3-Methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl]methyl]sulfinyl] -1H-Benzimidazole; |
Nambala ya CAS | 138530-94-6 |
Nambala ya CAT | Chithunzi cha RF-PI1916 |
Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
Molecular Formula | Chithunzi cha C16H14F3N3O2S |
Kulemera kwa Maselo | 369.36 |
Mtundu | Ruifu Chemical |
Kanthu | Zofotokozera |
Maonekedwe | Ufa Wa Crystalline Woyera mpaka Woyera |
Kusungunuka | Zosungunuka mu Dimethylformamide, Zosasungunuka M'madzi |
Kumveka & Mtundu wa Solution | Chimakwaniritsa Chofunikira |
Chizindikiro cha IR | Mayamwidwe a infrared spectrum ayenera kukhala ogwirizana ndi zomwe zikulozera |
Chizindikiro cha HPLC | Nthawi yosungira pachimake chachikulu iyenera kukhala yogwirizana ndi zomwe zatchulidwa |
Kuzungulira Kwapadera | +142.0°~+149.0° |
Melting Point | ~ 140.0 ℃ |
M'madzi (KF) | <1.00% |
Zotsalira pa Ignition | <0.10% |
Zowonongeka Zogwirizana nazo | (HPLC) |
Nayitrogeni okosijeni | <0.10% |
Sulfone | <0.40% |
Sulfidi | <0.20% |
Chidetso China Chilichonse Chimodzi | <0.10% |
Zonse Zonyansa | <0.60% |
Optical Purity (HPLC) | > 99.5% |
Kuyesa | 98.0~102.0% (HPLC, %w/w, yopanda madzi, yopanda zosungunulira) |
Zitsulo Zolemera | <10ppm |
Zosungunulira Zotsalira | |
Toluene | <890ppm |
n-Heptane | <5000ppm |
Bakiteriya Endotoxin | <2.5EU/mg |
Test Standard | USP Standard;Chinese Pharmacopoeia |
Kugwiritsa ntchito | API;Proton Pump Inhibitor Yogwira Ntchito Pakamwa |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi lamulo la kasitomala
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi
(R) -Lansoprazole (CAS: 138530-94-6) ndi R enantiomer ya Lansoprazole, Lansoprazole (AG 1749) ndi pakamwa yogwira proton pump inhibitor yomwe imalepheretsa m'mimba kupanga asidi.Dexlansoprazole ya Lansoprazole dextroisomer, ndi mtundu wa mankhwala odana ndi zilonda zam'mimba m'malo mwa zotumphukira za benzimidazole, mu cell dongosolo mu element fluorine, yachiwiri proton pump inhibitors omeprazole pambuyo.Dexlansoprazole ali ndi zotsatira zoletsa katulutsidwe wa chapamimba asidi, zotsatira zake ndi bwino kuposa mankhwala ena (Omeprazole, Pantoprazole, Rebela, Tetrazolium) akhoza kwambiri ziletsa kuchitika kwa chilonda.Ndi wapamwamba kuposa famotidine kapena Omeprazole chifukwa mowa anachititsa mucosa chapamimba ndi duodenal chilonda makamaka chifukwa asidi hypersecretion.Kuphatikiza apo, mankhwalawa ali ndi anti Helicobacter pylori monga kukonzekera kwa bismuth, ndipo amagwiritsidwa ntchito pa reflux esophagitis ndi matenda a Zhuo AI.Takeda Pharmaceuticals analandira chivomerezo cha dexlansoprazole, njira yapawiri yotulutsidwa ya (R) -isomer ya lansoprazol proton pump inhibitor (PPI) yomwe ili kale pamsika, kuchokera ku FDA mu Januwale 2009. Dexlansoprazole ndi kapisozi wochedwa kutulutsidwa kwa chithandizo chamkamwa kamodzi tsiku lililonse, Kupweteka kwapamtima komwe kumagwirizanitsidwa ndi chizindikiro cha matenda a reflux a gastroesophageal (GERD), machiritso a erosive esophagitis (EE) ndi kukonza EE yochiritsidwa.