Ramelteon Wapakatikati 12 CAS 1053239-39-6 Chiyero> 98.0% (HPLC)

2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride (CAS: 1053239-39-6) ndi yapakatikati ya Ramelteon (CAS: 196597- 26-9).Mosiyana ndi mankhwala ambiri a kusowa tulo omwe amakhudza GABA (g-aminobutyric acid) receptor complex, Ramelteon ndi agonist wa melatonin receptor.Makamaka, ili ndi kusankha kwakukulu kwa ma subtypes a MT1 ndi MT2, omwe adakhudzidwa ndi kusungitsa ma circadian rhythms, pa cholandirira cha MT3 chomwe chimayang'anira ntchito zina za melatonin.Kuperewera kwake kwa mgwirizano wa GABA receptor complex komanso neurotransmitter, dopaminerigic, opiate, ndi benzodiazepine receptors kumapereka chidziwitso chokhazikika chachitetezo chopanda kugwiritsa ntchito molakwika mankhwala ogodomalitsa omwe amayang'ana zolandilira izi.Momwemonso, Ramelteon si mankhwala okonzekera.Ma metabolites oyambira amaphatikiza hydroxylation ndi oxidation ku mitundu ya carbonyl yokhala ndi metabolites yachiwiri yobwera chifukwa cha glucuronidation.Popeza CYP1A2 ndiye isozyme yayikulu yomwe imakhudzidwa ndi kagayidwe kachiwindi ka Ramelteon, sayenera kutengedwa limodzi ndi zoletsa zamphamvu za CYP1A2, monga fluvoxamine.Kugwiritsiridwa ntchito limodzi ndi ketoconazole (CYP3A4 inhibitor) kapena fluconazole (yamphamvu CYP2C9 inhibitor) kumapangitsa kuwonjezeka kwakukulu kwa AUC ndi Cmax, koma kagayidwe kakang'ono ka Ramelteon kagayidwe kachakudya komanso kusinthasintha kwakukulu kwa plasma kumalepheretsa kufunika kosintha mlingo.Kuyika kwa phukusi, komabe, kumachenjeza odwala za kuyanjana ndi ma CYP3A4 amphamvu ndi CYP2C9 inhibitors.Kutengera zotsatira za mayeso azachipatala, mlingo woyenera wa Ramelteon ndi 8mg wotengedwa mkati mwa mphindi 30 mutagona.Kuphatikiza pa kusamala kwa kulamulira limodzi ndi CYP inhibitors, sayenera kugwiritsidwa ntchito kwa odwala omwe ali ndi vuto lalikulu la chiwindi.The chokhwima zochitika, anaona 5% ya odwala mu matenda maphunziro, anali kugona, chizungulire, nseru, kutopa, mutu, ndi kusowa tulo.