Sodium 4-Aminosalicylate CAS 133-10-8 Chiyero>99.0% (HPLC)

Sodium 4-Aminosalicylate (CAS: 133-10-8) imasungunuka mosavuta m'madzi, imasungunuka pang'ono mu ethanol, yosasungunuka mu acetone.Itha kugwiritsidwa ntchito ngati mankhwala odana ndi chifuwa chachikulu, makamaka pochiza matenda a chifuwa chachikulu.Izi ndi zofanana ndi 4-Aminobenzoic acid (PABA) mu kapangidwe, ndi congener wa PABA.Imalepheretsa kukula ndi kubereka kwa chifuwa chachikulu cha Mycobacterium mwa kuletsa mpikisano wa folate synthesis.Izi zimangogwira ntchito motsutsana ndi mycobacteria, osati atypical mycobacteria.Akagwiritsidwa ntchito okha, amatha kukhala osamva mankhwala.Mankhwalawa ayenera kuphatikizidwa ndi mankhwala ena odana ndi chifuwa chachikulu, monga streptomycin ndi isoniazid, zomwe zingachedwetse kupanga mankhwala kukana chifuwa chachikulu cha TB bacilli mpaka awiri otsiriza.Kachipatala, amagwiritsidwa ntchito makamaka pa chifuwa chachikulu cha m'mapapo ndi chotulukapo chifukwa cha Mycobacterium TB.Amagwiritsidwanso ntchito mu hyperthyroidism ndipo amakhudza kwambiri kutsitsa lipids m'magazi.Amatengedwa bwino kuchokera ku thirakiti la GI.Amayamwa mwachangu kuposa ma salicylic acid ena.Pambuyo mayamwidwe, izo mofulumira anagawira zosiyanasiyana madzimadzi a m'thupi ndi kufika mkulu ndende mu pleural madzimadzi, koma ndende mu cerebrospinal madzimadzi ndi otsika kwambiri.Mankhwalawa amafalikira mwachangu m'matumbo a impso, m'mapapo ndi m'chiwindi, ndikufikira kwambiri m'matenda a caseous.Ndi oyenera m`mapapo ndi extrapulmonary chifuwa chachikulu chifukwa Mycobacterium TB.Sodium para-aminosalicylate imagwira ntchito motsutsana ndi mycobacteria osati pa nontuberculous mycobacteria.Kukaniza kumatha kukula mwachangu mukagwiritsidwa ntchito payekha, motero kuyenera kuphatikizidwa ndi mankhwala ena odana ndi TB.Streptomycin ndi isoniazid, zikaphatikizidwa ndi iwo, zimatha kuchedwetsa kukula kwa matenda a chifuwa chachikulu cha Mycobacterium kwa mankhwalawa.Amagwiritsidwa ntchito makamaka ngati mankhwala amtundu wachiwiri wotsutsa chifuwa chachikulu.Itha kugwiritsidwanso ntchito pa hyperthyroidism, ndipo ndi yoyenera kwa odwala omwe ali ndi hyperthyroidism ndi chifuwa chachikulu.Pamene mankhwala a ayodini sakugwira ntchito ndipo amakhudza ntchitoyo, akhoza kutengedwa kwa kanthawi kochepa kuti apange zochitika za opaleshoniyo.Kulowetsedwa m'mitsempha nthawi zambiri kumagwiritsidwa ntchito kwambiri ngati tuberculous meningitis.