Sorafenib Tosylate CAS 475207-59-1 Purity ≥99.0% (HPLC) API Factory High Quality
Zogulitsa Zamalonda Sorafenib Tosylate ndi Zapakati Zofananira:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
| Dzina la Chemical | Sorafenib Tosylate |
| Mawu ofanana ndi mawu | Nexavar;4- [4--[3-[4-Chloro-3-(Trifluoromethyl))phenyl]ureido]phenoxy]-N-Methylpicolinamide 4-Methylbenzenesulfonate;4- [[4-Chloro-3-(Trifluoromethyl)phenyl]carbamamido]phenoxy]-N-Methyl-2-Pyridinecarboxamide 4-Methylbenzenesulfonate;BAY 43-9006 Tosylate |
| Nambala ya CAS | 475207-59-1 |
| Stock Status | Mu Stock, Kupanga Kufikira Mazana a Kilogram |
| Molecular Formula | C21H16ClF3N4O3.C7H8O3S |
| Kulemera kwa Maselo | 637.03 |
| Melting Point | 225.0 mpaka 230.0 ℃ |
| Zomverera | Simamva Kutentha, Kutentha |
| Kusungunuka | Zosungunuka m'madzi (<1 mg/ml) pa 25 ℃, DMSO (127 mg/ml) pa 25 ℃, ndi Ethanol (<1 mg/ml) pa 25 ℃ |
| Zoyenera Kutumiza | Malo Ozizira & Owuma (2 ~ 8 ℃), Tetezani Kuwala |
| COA & MSDS | Likupezeka |
| Shelf Life | Zaka 2 Ngati Zasungidwa Bwino |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera | Zotsatira |
| Maonekedwe | Ufa Woyera Wachikasu kapena Woyera | Zimagwirizana |
| Kuyera / Kusanthula Njira | ≥99.0% (HPLC) | 99.8% |
| Melting Point | 225.0 ~ 230.0 ℃ | Zimagwirizana |
| Zitsulo Zolemera | ≤10ppm | <10ppm |
| Kutaya pa Kuyanika | ≤0.50% | 0.12% |
| Zotsalira pa Ignition | ≤0.20% | 0.10% |
| Chidetso Chilichonse Chilichonse | ≤0.50% | Zimagwirizana |
| Zonse Zonyansa | ≤0.50% | Zimagwirizana |
| Chithunzi cha NMR | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| Test Standard | Enterprise Standard | Zimagwirizana |
| Kugwiritsa ntchito | Sorafenib Tosylate (CAS: 475207-59-1) pochiza RCC & HCC | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani mu chidebe chotsekedwa mwamphamvu.Sungani pamalo ozizira, owuma (2 ~ 8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Zizindikiro Zowopsa 36/37/38 - Zokwiyitsa maso, kupuma komanso khungu.
Kufotokozera Zachitetezo S28 - Mukakhudza khungu, sambani nthawi yomweyo ndi sopo wambiri.
S26 - Mukakhudzana ndi maso, muzimutsuka nthawi yomweyo ndi madzi ambiri ndipo funsani malangizo achipatala.
Sorafenib Tosylate (CAS: 475207-59-1) ndi mtundu watsopano wa mankhwala oletsa kutupa omwe ali ndi zolinga zambiri, adapangidwa ndi German Bayer Pharmaceuticals, ndipo adawonetsa ntchito yowonjezereka ya antitumor pamayesero anyama asanakwane.Sorafenib imapezeka m'mapiritsi a 200-mg pakamwa ndipo imagwiritsidwa ntchito pochiza RCC ndi HCC.Sorafenib Tosylate imatha kukhudza nthawi imodzi ma cell chotupa ndi mitsempha yamagazi.Imakhala ndi mphamvu yoletsa kutupa: imatha kuletsa njira zolumikizira ma cell zomwe zimalumikizidwa ndi RAF/MEK/ERK kuti ziletse mwachindunji kukula kwa cell chotupa, komanso kuletsa VEGF ndi mapulateleti opangidwa ndi kukula kwazinthu (PDGF) zolandilira kuteteza mapangidwe amagazi atsopano. ziwiya, motero mosalunjika kuletsa chotupa maselo kukula.
Sorafenib Tosylate, dzina lamalonda Nexavar, idapangidwa koyamba ndi Bayer Pharmaceuticals ku Germany.Sorafenib Tosylate ndi multikinase inhibitor yomwe ingagwiritsidwe ntchito pochiza matenda monga khansa.Mu Disembala 2005, idavomerezedwa ndi US FDA ngati mankhwala oyamba ochizira khansa yapamwamba yaimpso.Mu Ogasiti 2009, idalembedwa mwalamulo ku China ndi chilolezo cha State Food and Drug Administration.
Sorafenib Tosylate ndi tyrosine kinases (VEGFR ndi PDGFR) ndi RAF/MEK/ERK cascade inhibitors, amagwira ntchito nthawi imodzi pa Raf-1,wtBRAF ndi V599EBRAF, ndi IC50 ya 6 nM, 22 nM ndi 38 nM, motsatira.
Sorafenib Tosylate imatha kuletsa nthawi imodzi ma kinase osiyanasiyana omwe amapezeka pa cell ndi cell, kuphatikiza RAF kinase, vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor receptor-3 (VEGFR-3), platelet. -derived growth factor receptor-β (PDGFR-β), KIT ndi FLT-3.Zitha kuwoneka kuti sorafenib toluenesulfonate ili ndi zotsatira ziwiri zotsutsana ndi chotupa.Kumbali imodzi, imatha kuletsa mwachindunji kukula kwa chotupa mwa kuletsa njira yowonetsera RAF/MEK/ERK;kumbali ina, imatha kuletsa VEGFR ndi PDGFR.Ndipo kuletsa mapangidwe chotupa neovascularization, mosalunjika ziletsa kukula kwa chotupa maselo.Sorafenib Tosylate ndiye mankhwala othandiza kwambiri pochiza khansa ya m'chiwindi yomwe ikupita patsogolo pogwiritsa ntchito dongosolo lazinthu, ndipo mwina adzakhala mankhwala atsopano ochizira matendawa.
Sorafenib Tosylate kamodzi pa tsiku pakamwa pakamwa pamtundu wa nyama zotupa zamtundu wa anthu adawonetsa zochitika zambiri zotsutsana ndi chotupa, kuphatikiza khansa ya m'matumbo, khansa ya m'matumbo, khansa ya m'mawere, khansa ya m'mawere, khansa ya melanoma, khansa ya pancreatic, khansa ya m'magazi ndi khansa ya ovarian ndi mbewa ya renal cell carcinoma. model, RENCA model.
