Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API Factory High Purity
Wopanga ndi Kuyera Kwambiri ndi Ubwino Wokhazikika
Dzina la mankhwala: Tacrolimus
Mawu ofanana: FK-506;Fujimycin
CAS: 104987-11-3
API, High Quality, Commercial Production
Dzina la Chemical | Tacrolimus |
Mawu ofanana ndi mawu | FK-506;Fujimycin |
Nambala ya CAS | 104987-11-3 |
Nambala ya CAT | RF-API46 |
Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
Molecular Formula | C44H69NO12 |
Kulemera kwa Maselo | 804.02 |
Mtundu | Ruifu Chemical |
Kanthu | Zofotokozera |
Maonekedwe | Ufa Woyera-Woyera kapena Wachikasu Wotuwa, Wopanda fungo, Kukoma Kwapadera Kwapadera |
Chizindikiritso | Ziyenera Kukhala Zabwino |
Kumveka bwino | Tsatirani Muyezo |
pH | 5.0-6.0 |
Chloride | ≤0.014% |
Sulphate | ≤0.029% |
Zitsulo Zolemera (Pb) | ≤10ppm |
Arsenic | ≤0.0002% |
Chinyezi (KF) | ≤8.0% |
Zotsalira pa Ignition | 18.0% ~ 22.0% |
Kuyesa | ≥72.0% (HPLC, pa zouma) |
Test Standard | Enterprise Standard |
Kugwiritsa ntchito | API |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
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Tacrolimus (komanso FK-506 kapena Fujimycin) ndi immunosuppressive mankhwala amene ntchito yaikulu pambuyo kumuika chiwalo kuchepetsa ntchito ya chitetezo cha m'thupi la wodwalayo komanso chiopsezo kukana chiwalo.Amagwiritsidwanso ntchito pokonza apakhungu pochiza kwambiri atopic dermatitis, kwambiri refractory uveitis pambuyo poika mafupa am'mafupa, komanso khungu la vitiligo.Tacrolimus anatengedwa koyamba ku fermentation msuzi wa Streptomyces tssukuba, tizilombo toyambitsa matenda tomwe timapezeka ku Tsukuba, Japan.Dzina la tacrolimus limachokera ku 't' ya Tsukuba, dzina la phiri kumene dothi linatengedwa, 'acrol' ya macrolide ndi 'imus' ya immunosuppressant.Ngakhale kuti sichigwirizana ndi cyclosporin, tacrolimus imasonyeza kufanana kwa immunosuppressive zotsatira kwa wothandizira pa ma cell ndi maselo.Kafukufuku woyambirira adawonetsa kuti tacrolimus inali yamphamvu ya immunosuppressant, yowonetsa pafupifupi 100 kuwirikiza mu vitro potency kuposa cyclosporin poletsa T cell activation.Kafukufuku wotsatira mu vivo awonetsa kuti tacrolimus imakhala yothandiza poletsa matenda odzidzimutsa komanso oyesera a autoimmune, komanso popewa kukana kwa allograft ndi xenograft m'mitundu ya nyama zoyika ziwalo.Poyambirira, tacrolimus idagwiritsidwa ntchito ngati systemic immunosuppression ya odwala omwe adachitidwa opaleshoni kuti awaletse kukana ma graft awo atsopano.Posakhalitsa, komabe, kupyolera mu phindu la serendipity ya sayansi, zinadziwika kuti tacrolimus ikhoza kubweretsa zotsatira zabwino pazovuta za khungu mwa odwala ena omwe adayikidwapo.Kupezeka kwa tacrolimus kotero kwapangitsa kumvetsetsa kwakukulu kwa matenda a khungu, mwachitsanzo atopic dermatitis.Pambuyo pake, ntchito zina zam'mutu za tacrolimus zidanenedwa ndipo kugwiritsa ntchito mankhwalawa mu dermatology kukukulirakulira.
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