Tranexamic Acid CAS 1197-18-8 Mayeso 99.0~101.0% (Titration)

Tranexamic Acid
C8H15NO2 157.2
trans-4-(Aminomethyl) cyclohexanecarboxylic acid;
Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans [1197-18-8].
TANTHAUZO
Tranexamic Acid ili ndi NLT 99.0% ndi NMT 101.0% ya C8H15NO2, yowerengedwa pa zouma.
CHIZINDIKIRO
• Infrared mayamwidwe <197K>
ZOYESA
• Ndondomeko
Njira yothetsera zitsanzo: 140 mg ya Tranexamic Acid mu 20 ml ya glacial acetic acid
Titrimetric system
(Onani Titrimetry <541>.)
Mode: Direct titration
Titrant: 0.1 N perchloric acid VS
Kuzindikira komaliza: Potentiometric
Kusanthula
Chitsanzo: Yankho lachitsanzo
Titrate ndi 0.1 N perchloric acid VS, kudziwa mapeto potentiometrically.Chitani mawu opanda kanthu.
ML iliyonse ya 0.1 N perchloric acid ndi yofanana ndi 15.72 mg ya C8H15NO2.
Njira zolandirira: 99.0% -101.0% pazowuma
ZOCHITSA
Zowonongeka Zachilengedwe
• Zotsalira pakuyatsa <281>: NMT 0.1%;1-g chitsanzo amagwiritsidwa ntchito
• Zitsulo Zolemera, Njira II <231>: NMT 10 ppm
• Chloride ndi Sulfate, Chloride <221>: Gawo la 0.51-g limasonyeza kuti palibe 0.1 ml ya 0.020 N hydrochloric acid (0.014%).
Zowonongeka Zachilengedwe
• Ndondomeko
Gawo la mafoni: Sungunulani 11.0 g ya anhydrous monobasic sodium phosphate mu 500 ml ya madzi, ndi kuwonjezera 5 mL ya triethylamine, kenako 1.4 g ya sodium lauryl sulfate.Sinthani ndi diluted phosphoric acid (10% w/w) kukhala pH ya 2.5, ndi kuchepetsedwa ndi madzi mpaka 600 mL.Sakanizani njira iyi ndi 400 ml ya methanol.
Njira yothetsera kuyenerera: 0.2 mg/mL ya USP Tranexamic Acid RS ndi 0.002 mg/mL ya USP Tranexamic Acid Related Compound C RS m'madzi
Njira yothetsera: 50 µg/mL ya USP Tranexamic Acid RS m'madzi
Njira yothetsera chitsanzo: 10 mg/mL ya Tranexamic Acid m'madzi
Chromatographic system
(Onani Chromatography <621>, Kukwanira Kwadongosolo.)
Njira: LC
Chowunikira: UV 220 nm
Mzere: 4.6-mm × 25-cm;5-µm kunyamula L1
Kuthamanga: 1 mL / min
Kukula kwa jekeseni: 20µL
Nthawi yothamanga: katatu nthawi yosungira tranexamic acid
Kuyenerera kwadongosolo
Zitsanzo: Yankho lolingana ndi dongosolo
Zofunikira zoyenera
Kusamvana: NLT 2.0 pakati pa Tranexamic Acid ndi 0.002 mg/mL ya tranexamic acid yokhudzana ndi gulu C
Kusanthula
Zitsanzo: Yankho lokhazikika ndi yankho lachitsanzo
Kuwerengera kuchuluka kwa zodetsa za munthu aliyense pagawo la Tranexamic Acid lomwe watengedwa:
Zotsatira = (rU/rS) × (CS/CU) × (0.1F)
rU = kuyankha pachimake pachidetso chilichonse kuchokera ku Sample solution
rS = kuyankha kwapamwamba kwa tranexamic acid kuchokera ku Standard solution
CS = kuchuluka kwa USP Tranexamic Acid RS mu Standard solution (µg/mL)
CU = kuchuluka kwa Tranexamic Acid mu Sample solution (mg/mL)
F = chinthu choyankhirako (onani Table 1)
Zovomerezeka zovomerezeka
Zodetsedwa zapayekha: Onani Table 1.
Zonyansa zonse: NMT 0.2%
[Zindikirani-Musanyalanyaze chiwongola dzanja chilichonse chochepera 0.025%.]
Table 1
Tchulani Chiyankhulo Chosunga Nthawi Yogwirizana ndi Mayankho Zomwe Mumavomereza, NMT (%)
Tranexamic acid yokhudzana ndi gulu Aa 2.1 1 0.1
Tranexamic acid yokhudzana ndi pawiri Bb 1.5 1.2 0.2
Tranexamic acid yokhudzana ndi pawiri Cc 1.1 0.005 0.1
Tranexamic Acid 1.0 1.0 -
Tranexamic acid yokhudzana ndi chigawo Dd 1.3 0.006 0.1
trans,trans-4,4¢-(Iminodimethylene)di(cyclohexanecarboxylic)asidi.
b cis-4-(Aminomethyl) cyclohexanecarboxylic acid.
c (RS) -4- (Aminomethyl) cyclohex-1-enecarbocylic acid.
d 4-aminomethyl benzoic acid.
MAYESO AKE
• Kutaya pa Kuyanika <731>: Yanikani 1.00 g pa 105 pansi pa vacuum kwa 2 h.Imataya NMT 0.5% ya kulemera kwake.
ZOWONJEZERA ZOFUNIKA
• Kupaka ndi Kusunga: Sungani m’zotengera zothina, ndipo sungani pa kutentha kosapitirira 30.
• USP Reference Standards <11>
USP Tranexamic Acid RS Dinani kuti muwone Kapangidwe
USP Tranexamic Acid Related Compound C RS
(RS) -4- (Aminomethyl) cyclohex-1-enecarbocylic acid.
C8H13NO2 155