trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Purity >98.0% (HPLC) Afatinib Dimaleate Intermediate

Kufotokozera Kwachidule:

Trans-4-Dimethylaminocrotonic Acid Hydrochloride

CAS: 848133-35-7

Kuyera: > 98.0% (HPLC)

Maonekedwe: Ufa Woyera Mpaka Pafupifupi Woyera

Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

Lumikizanani ndi Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Kufotokozera:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imodzi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineChithunzi cha CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Dzina la Chemical	Trans-4-Dimethylaminocrotonic Acid Hydrochloride
Mawu ofanana ndi mawu	trans 4-Dimethylaminocrotonic Acid HCl;(E) -4- (Dimethylamino) -2-Butenoic Acid Hydrochloride;(E) -4-Dimethylaminocrotonic Acid Hydrochloride;(2E) -4- (Dimethylamino) koma-2-Enoic Acid Hydrochloride;Afatinib int-2
Nambala ya CAS	848133-35-7
Stock Status	Mu Stock, Commercial Scale
Molecular Formula	C6H12ClNO2
Kulemera kwa Maselo	165.62
Kumverera	Hygroscopic.Sichinyezimira
Melting Point	160.0 mpaka 164.0 ℃
Kusungunuka	DMSO (Pang'ono), Methanol (Pang'ono), Madzi (Pang'ono)
COA & MSDS	Likupezeka
Chiyambi	Shanghai, China
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Ufa Woyera mpaka Pafupifupi Woyera
Kuyera / Kusanthula Njira	>98.0% (HPLC)
Kuyera / Kusanthula Njira	>98.0% (NMR)
Chinyezi (KF)	<0.50%
Zotsalira pa Ignition	<0.20%
Chidetso Chimodzi	<0.50%
Zitsulo Zolemera (monga Pb)	<20ppm
Infrared Spectrum	Zimagwirizana ndi Kapangidwe
1 H NMR Spectrum	Proton NMR Spectrum
Test Standard	Enterprise Standard
Kugwiritsa ntchito	Pakati pa Afatinib, Afatinib Dimaleate

Phukusi & Kusungira:

Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.

Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi.

Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.

Chromatographic Purity:

Chida: Agilent 1200 HPLC HPLC chromatograph, DAD detector.
Mzere: Agilent XDB-C18,250*4.6mm, 5μm
Mobile gawo: B: 1.95g sodium octane sulfonate + 8ml phosphoric asidi + 5ml triethylamine + 500ml madzi
C: acetonitrile
Kukonzekera gawo losakanikirana la mafoni: tengani 400ml B yankho ndi 100ml acetonitrile, sakanizani bwino komanso molingana, ndikupopera madziwo mu gawo limodzi.
Kuthamanga kwapakati: 0.5ml/min54bar
Kutentha kwapakati: 25 ℃
Kutalika: 210nm
Yankho chitsanzo: gawo mafoni ntchito monga zosungunulira, olimba chitsanzo: 0.0040g/2ml, chitsanzo kukula 2.0μl.

Ubwino:

FAQ:

Ntchito:

trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) ndi reagent yomwe imagwiritsidwa ntchito pokonzekera tyrosine kinase inhibiting antitumor agents.trans-4-Dimethylaminocrotonic Acid Hydrochloride ingagwiritsidwe ntchito ngati pakati pa Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Afatinib ndi mankhwala ovomerezeka kuti azichiza omwe si aang'ono cell lung carcinoma (NSCLC), opangidwa ndi Boehringer Ingelheim.Amagwira ntchito ngati angiokinase inhibitor.Monga Lapatinib ndi Neratinib, Afatinib ndi tyrosine kinase inhibitor (TKI) yomwe imalepheretsanso anthu kukulitsa kukula kwa chinthu cholandirira 2 (Her2) ndi epidermal growth factor receptor (EGFR) kinases.Afatinib samangogwira ntchito motsutsana ndi EGFRmasinthidwe omwe amatsata m'badwo woyamba wa TKIs likeerlotinib kapena gefitinib, komanso motsutsana ndi omwe samakhudzidwa ndi machiritso awa.Chifukwa cha ntchito yake yowonjezera yolimbana ndi Her2, ikufufuzidwa za khansa ya m'mawere komanso khansa zina zoyendetsedwa ndi EGFR ndi Her2.Neratinib yopangidwa ndi kampani ya US Wyeth ndi inhibitor yosasinthika ya epidermal growth factor receptor(EGFR).Ndi malo angapo omwe amatsata mamolekyu ang'onoang'ono a tyrosine kinase inhibitors kupita ku HER 2 ndi HER1 pambuyo pa Lapatinib, ndipo ndi ErbB receptor tyrosine kinase inhibitor yosasinthika.Neratinib akhoza kusankha ziletsa HER-1 ndi HER-2 wa EGFR banja (IC50 anali 92 nmol/L ndi 59 nmol/L, motero).Kafukufuku wachipatala adawonetsa kuti Neratinib idathandizira kwambiri khansa ya m'mapapo yopanda maselo, khansa ya m'matumbo, ndi khansa ya m'mawere.Mayesero a PhaseⅡclinical adawonetsa kuti Neratinib idawonetsa kuchita bwino komanso kulolerana kwa odwala omwe ali ndi HER-2 omwe ali ndi khansa ya m'mawere yapamwamba omwe adalandira kapena ayi chithandizo cha Trastuzumab.Gawo Ⅲ kuyesa kwachipatala cha khansa ya m'mawere kunamalizidwa mu Seputembala 2014.