Zoledronic Acid CAS 118072-93-8 Purity ≥99.7% API Factory High Quality
Perekani ndi Kuyera Kwambiri ndi Ubwino Wokhazikika
Dzina la Chemical: Zoledronic Acid
CAS: 118072-93-8
Mphamvu ya Farnesyl Diphosphate (FPP) Synthase Inhibitor
API High Quality, Commercial Production
| Dzina la Chemical | Zoledronic acid |
| Mawu ofanana ndi mawu | ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid |
| Nambala ya CAS | 118072-93-8 |
| Nambala ya CAT | RF-API90 |
| Stock Status | Mu Stock, Kupanga Kufikira Mazana a Kilogram |
| Molecular Formula | Chithunzi cha C5H10N2O7P2 |
| Kulemera kwa Maselo | 272.09 |
| Melting Point | 193.0 ~ 204.0 ℃ |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Wa Crystalline Woyera mpaka Woyera |
| Chizindikiritso | IR Spectrum yachitsanzo imafanana ndi muyezo wolozera |
| pH | 2.0-4.0 |
| Kusungunuka | Kusungunuka pang'ono mu 0.1N Sodium Hydroxide Solution, Kusungunuka Pang'ono M'madzi ndi 0.1N Hydrochloric Acid, Pafupifupi Insoluble mu Ethanol |
| Zogwirizana nazo | |
| Chidetso Chilichonse Chamunthu | ≤0.10% |
| Zonse Zonyansa | ≤0.30% |
| Kutaya pa Kuyanika | 5.0% ~ 7.0% |
| Chloride | ≤0.02% |
| Phosphite | ≤0.50% |
| Phosphate | ≤0.50% |
| Zitsulo Zolemera | ≤10ppm |
| Chiyero | ≥99.7% |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | API, FPP Synthase Inhibitor, Hypercalcemia of Malignancy (HCM) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
Zoledronic Acid (CAS 118072-93-8) ndi bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM) yamphamvu.Imalepheretsa osteoclast-mediated bone resorption.Imalepheretsanso kuwonetsa kwa Ras ndi kukula kwa chotupa, ndipo imapangitsa kuti apoptosis m'maselo a khansa ya pancreatic.Imatembenuza kusintha kwa epithelial-mesenchymal ndikuletsa kukonzanso maselo a khansa ya m'mawere kudzera mwa inactivation ya NF-κB.Zoledronic acid idavomerezedwa ndi US FDA mu 2001 pochiza hypercalcemia ya malignancy, vuto la metabolic lomwe lingakhale pachiwopsezo cha moyo.Hypercalcemia ya malignancy imatha kuchitika mpaka 50% ya odwala omwe ali ndi khansa ya m'mawere yapamwamba, myeloma yambiri, komanso khansa ya m'mapapo yocheperako.Izi zimachitika pamene zigawo za mankhwala opangidwa ndi chotupa zimayambitsa overstimulation wa osteoclasts.Pamene pali kuwonjezeka kwa mafupa kuwonongeka, pali concomitant kutulutsidwa kwa kashiamu mu plasma.Pamene seramu woipa wa kashiamu mofulumira kukweza, impso sangathe kupirira mochulukira, ndi hypercalcemia zotsatira.Zoledronic acid imachepetsa kuchuluka kwa kashiamu m'madzi a m'magazi mwa kulepheretsa kukhazikika kwa mafupa (kuletsa kwa osteoclastic ntchito ndi kulowetsedwa kwa osteoclast apoptosis).Kuphatikiza apo, zoledronic acid yavomerezedwa ndi US FDA pochiza ma myeloma angapo ndi ma metastases a mafupa okhudzana ndi khansa yolimba yochokera ku chotupa (mwachitsanzo, kugwada ndi mapapo).
