One of Hottest for Ropivacaine HCl.H2O - Ambrisentan CAS 177036-94-1 Purity >99.0% (HPLC) API Factory High Purity – Ruifu

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One of Hottest for Ropivacaine HCl.H2O - Ambrisentan CAS 177036-94-1 Purity >99.0% (HPLC) API Factory High Purity – Ruifu Detail:

Commercial Supply Ambrisentan (CAS: 177036-94-1) Related Intermediates:
Ambrisentan CAS: 177036-94-1
Methyl 2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoate CAS: 178306-47-3
2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoic Acid CAS: 178306-51-9
(S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS: 178306-52-0
L-Proline Methyl Ester Hydrochlorid CAS: 2133-40-6
4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine CAS: 35144-22-0

Chemical Name Ambrisentan
Synonyms (S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-Methoxy-3,3-Diphenylpropionic Acid; (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-Methoxy-3,3-Diphenylpropanoic Acid
CAS Number 177036-94-1
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C22H22N2O4
Molecular Weight 378.43
Specific Rotation [α]D20 +170.0° to +176.0° (C=0.5, MeOH)
Melting Point 172.0~178.0℃(dec.)
Solubility Very Soluble in Methanol; Soluble in Ethanol, Acetone; Insoluble in Water
Brand Ruifu Chemical
Item Specifications
Appearance White or Off-White Powder
Identification HPLC;  NMR; LC-MS
Related Substances
Individual Impurity ≤0.50%
Total Impurities <1.00%
Loss on Drying ≤0.50%
Residue on Ignition ≤0.20%
Heavy Metals ≤20ppm
Purity / Analysis Method >99.0% (HPLC)
Test Standard Enterprise Standard
Usage Pharmaceutical Intermediates

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

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Ambrisentan (CAS: 177036-94-1) is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors. In June of 2007, the FDA granted approvalof ambrisentan for once-daily treatment of PAH.


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