Online Exporter Irinotecan Hydrochloride - Tenofovir Disoproxil Fumarate CAS 202138-50-9 Assay 98.0%~102.0% API Factory – Ruifu
Online Exporter Irinotecan Hydrochloride - Tenofovir Disoproxil Fumarate CAS 202138-50-9 Assay 98.0%~102.0% API Factory – Ruifu Detail:
Commercial Supply Tenofovir Related Intermediates:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Chloromethyl Isopropyl Carbonate CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl)phosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0
Diethyl (Hydroxymethyl)phosphonate CAS 3084-40-0
Adenine CAS 73-24-5
| Chemical Name | Tenofovir Disoproxil Fumarate |
| Synonyms | Tenofovir DF; Bis(POC)-PMPA Fumarate; GS 4331 Fumarate |
| CAS Number | 202138-50-9 |
| CAT Number | RF-API106 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C23H34N5O14P |
| Molecular Weight | 635.52 |
| Melting Point | 113.0 to 115.0℃ |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White or Almost White Powder |
| Identification A | IR Spectrum Conforms to Reference Standard |
| Identification B | The retention time of the major peak from the sample solution corresponds to that of the standrd solution,as obtained in the test |
| Assay | 98.0%~102.0% (on anhydrous basis) |
| Water | ≤1.0% |
| Fumaric Acid | 17.5%~19.0% |
| Residue on Ignition | ≤0.20% |
| Heavy Metals | ≤20ppm |
| Chloromethyl Isopropyl Carbonate | ≤0.15% |
| Related Substances | |
| Tenofovir | ≤0.15% |
| Adenine | ≤0.15% |
| Tenofovir Isoproxi Monoester | ≤1.0% |
| Tenofovir Disoproxil Ethyl Ester | ≤0.15% |
| Tenofovir Isopropyl Isoproxil | ≤0.30% |
| Tenofovir Disoproxil Carbamate | ≤0.15% |
| Tenofovir Disproxil | ≤0.15% |
| Any Single Impurity | ≤0.10% |
| Total Impurities | ≤2.0% |
| Test Standard | Enterprise Standard |
| Usage | API |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer’s requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
Tenofovir Disoproxil Fumarate (CAS: 202138-50-9), a prodrug of tenofovir (Trade name: Viread) developed by Gilead Sciences, is a kind of nucleotide-analogues antiretroviral drugs, taking effect through acting as the reverse transcriptase inhibitors[nRTIs], which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. It should be noted that it is the first nucleotide reverse transcriptase inhibitor that has ever used for the treatment of HIV infection. Tenofovir Disoproxil Fumarate is converted to tenofovir in vivo, which is an acyclic nucleoside phosphonate[nucleotide] analog of adenosine 5′-monophosphate. It is generally used in combination with other kinds of medicine. HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines[called an HIV regimen] every day can help people with HIV live longer, healthier lives. Based on the FDA document, tenofovir disoproxil fumarate can also be for the treatment of chronic hepatitis B virus [HBV] infection in adults and children 12 years of age and older.
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