Paroxetine Hydrochloride Hemihydrate CAS 110429-35-1 Assay 97.5~102.0% Factory
Ruifu Chemical Supply With High Purity
Paroxetine Hydrochloride Hemihydrate CAS 110429-35-1
N-Methyl Paroxetine CAS 110429-36-2
| Chemical Name | Paroxetine Hydrochloride Hemihydrate |
| Synonyms | (3S,4R)-(-)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride Hemihydrate; Paxil; Seroxat; BRL29060 Hydrochloride Hemihydrate; BRL29060A Hemihydrate; Paroxetine-D4 HCl |
| CAS Number | 110429-35-1 |
| CAT Number | RF-PI1946 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C19H20FNO3·HCl·1/2H2O |
| Molecular Weight | 374.84 |
| Melting Point | 140.0~143.0℃ |
| Specific Rotation [α]20/D | -88.0° to -92.0° (C=1, MeOH, Calcd.on anh.substance) |
| Solubility | Practically Insoluble in Water; Very Soluble in Dimethylformamide, Methanol; Soluble in Ethanol |
| Brand | Ruifu Chemical |
| Contents | Specifications | Results |
| Appearance |
White or Almost White Crystalline Powder | Conform |
| Identification A |
The infrared absorption spectrum should be consistent with the reference spectrum | Conform |
| Identification B | The main peak area and retention time of the test solution should be consistent with the reference solution | Conform |
| Identification C | Water (by K.F) | Conform |
| Identification D | Reaction of Chlorides | Conform |
| Impurity D |
≤0.20% | Absent |
| Impurity G | ≤0.001% | |
| Related Substances |
Impurity A: ≤0.30% | 0.03% |
| Unspecified Impurities: For each impurity, ≤0.10% | 0.06% | |
| Total Impurities: ≤0.50% | 0.10% | |
| Heavy Metals | ≤0.002% | <0.002% |
| Water (by K.F) | 2.20%~2.70% | 2.46% |
| Sulfated Ash | ≤0.10% | <0.10% |
| Assay | 97.5%~102.0% (Anhydrous Substance) | 100.2% |
| Residual Solvents | ||
| Methanol | ≤0.30% | 0.001% |
| Acetone | ≤0.50% | 0.001% |
| Isopropanol | ≤0.50% | 0.04% |
| Dichloromethane | ≤0.06% | None |
| Toluene | ≤0.089% | 0.003% |
| Conclusion: Conforming to EP7.0. | ||
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
Paroxetine Hydrochloride Hemihydrate (CAS: 110429-35-1) is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant. It's a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). Antidepressant and anxiolytic in vivo. Paroxetine hydrochloride can be used to treat depression, which is a new antidepressant drug. It can also be used to treat panic attack, generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder (OCD), insomnia, premenstrual syndrome, premature ejaculation and other diseases, with good curative effect and less adverse reactions. Treat all types of depression. Including depression with anxiety and reactive depression. Common depressive symptoms: fatigue, sleep disorders, lack of interest and pleasure in daily activities, loss of appetite. After the curative effect is satisfied, it can prevent the recurrence of depression.
