Potassium Bis(trimethylsilyl)amide CAS 40949-94-8 (0.5M Solution in Toluene)

Short Description:

Potassium Bis(trimethylsilyl)amide (0.5M Solution in Toluene)

Synonyms: Hexamethyldisilazane Potassium Salt; KHMDS

CAS: 40949-94-8

Content of Active Base: 0.45~0.55 M

Appearance: Yellow to Brown Liquid

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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Potassium Bis(trimethylsilyl)amide (0.5M Solution in Toluene) (CAS: 40949-94-8) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	Potassium Bis(trimethylsilyl)amide
Synonyms	Hexamethyldisilazane Potassium Salt; Potassium Hexamethyldisilazane; KHMDS
CAS Number	40949-94-8
CAT Number	RF-PI2227
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C6H18KNSi2
Molecular Weight	199.49
Boiling Point	111℃
Density	0.877 g/mL at 25℃
Hazard Class	3 (8); Flammable Liquid, Corrosive
Packing Group	II
Solubility	Miscible With Terahydrofuran, Ether, Benzene and Toluene
Water Solubility	Reacts With Water
Hydrolytic Sensitivity	8: Reacts Rapidly With Moisture, Water, pProtic Solvents
Stability	Moisture Sensitive, Air Sensitive, Heat Sensitive. Store Under Nitrogen. May Form a Precipitate. Ambient Temperatures.
Safety	Hazardous-An Additional Dangerous Goods Freight Charge May Apply
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	Yellow to Brown Liquid
Other Impurities	≤3.00%
Content of Active Base	0.45~0.55 M
Test Standard	Enterprise Standard

Package & Storage:

Package: Bottle, or according to customer's requirement.

Storage Condition: It is sensitive to moisture and air. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Handle and store under inert gas. Incompatible with strong oxidizing agents.

Hazard Statements: Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. May cause drowsiness or dizziness.

Advantages:

FAQ:

Application:

Potassium Bis(trimethylsilyl)amide (0.5M Solution in Toluene) (commonly abbreviated as KHMDS) (CAS: 40949-94-8) is a strong, non-nucleophilic base with an approximate pKa of 26 (compare to lithium diisopropylamide, at 36). It is commercially available as a solid and as a solution in a variety of solvents (ex. THF, 2Me-THF, toluene, and MTBE). Similar reagents include lithium bis(trimethylsilyl)amide (LiHMDS) and sodium bis(trimethylsilyl)amide (NaHMDS). Non-nucleophilic megasteric strong base. Pharmaceutical intermediates, used in the production of synthetic cephalosporins. KHMDS is a chemical reagent used in preparative high-performance liquid chromatography. It is used to form stable complexes with potassium, which are then separated by the column. KHMDS is also used in biochemical research and as an asymmetric synthesis catalyst. KHMDS is a strong base used in the alkylation carbonyl compounds. KHMDS is used in the preparation of 5-Azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions.