Renewable Design for Palonosetron Hydrochloride Intermediate - Guanosine CAS 118-00-3 Purity ≥98.0% (HPLC) Assay 97.0-103.0% (UV) High Purity – Ruifu

Manufacturer Supply Nucleosides Intermediates with High Purity and Stable Quality

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Guanosine (CAS: 118-00-3) with high quality,widely used in organic synthesis, synthesis of pharmaceutical intermediates and fine chemical synthesis. Guanosine (CAS: 118-00-3) is an important intermediate of food and pharmaceutical products. Guanosine (CAS: 118-00-3) can be used to synthesize food fresheners – Disodium 5′-Guanylate (CAS: 5550-12-9), Disodium Guanylate (CAS: 5550-12-9) and nucleoside antiviral drugs such as Ribavirin (CAS: 36791-04-5) and Acyclovir (CAS: 59277-89-3) . It is also the main raw material for the manufacture of Acyclovir (CAS: 59277-89-3), Triazole Nucleoside (ATC), Guanosine Triphosphate (GTP) and other drugs.

Guanosine is a purine nucleoside, in which the guanine attached to the C1 carbon of a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Its phosphorylated derivatives include GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate). These guanosine derivatives are very important in various biochemical processes, such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction. Guanosine is thought to have neuroprotective properties. It can reduce neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells. It is shown to be protective in central nervous system diseases including ischemic stroke, Alzheimer’s disease, Parkinson’s disease, spinal cord injury, nociception, and depression. Guanosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency, which is an inborn error of metabolism.