2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5 Mama ≥98.0% Olaparib Intermediate Factory
Mamalu Maualuga, Gaosiga Faapisinisi
Olaparib ma isi fa'atatau:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Igoa Vailaau | 2-Fluoro-5-Formylbenzonitrile |
| Synonyms | 3-Cyano-4-Fluorobenzaldehyde |
| Numera CAS | 218301-22-5 |
| CAT Numera | RF-PI451 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C8H4FNO |
| Molecular Weight | 149.12 |
| Lisi Lisi | 80.0 i le 84.0 ℃ (malamalama) |
| Solubility | Solu i le Methanol |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Samasama ile Pa'u Pa'epa'e |
| Mama | ≥98.0% |
| Susū (KF) | ≤0.50% |
| Aofa'i Fa'aleaga | ≤2.0% |
| Tulaga Su'ega | Enterprise Standard |
| Fa'aoga | Vaitaimi ole Olaparib (CAS: 763113-22-0) PARP-Inhibitor |
afifi: Fagu, Ato pepa alumini, Pusa Pusa, 25kg / Paʻu, poʻo e tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu.
2-Fluoro-5-Formylbenzonitrile (CAS: 218301-22-5) o loʻo faʻaaogaina i le sauniuniga o mea faʻapipiʻi heterocyclic e avea ma inhibitors PARP mo le faʻaaogaina faafomaʻi.2-Fluoro-5-Formylbenzonitrile o loʻo faʻaaogaina e avea o se vaeluaga ole Olaparib (CAS: 763113-22-0).Olaparib o se fa'agata mole mole o le PARP1/PARP2 (IC50: 5/1 nM) ae le aoga tele i le PARP tankyrase-1 (IC50: 1.5 µM).Olaparib (AZD-2281, igoa tau fefa'ataua'iga Lynparza) ose fa'ata'ita'iga fa'atatau mo le kanesa ua fa'amaonia e le FDA, na atia'e e KuDOS Pharmaceuticals ma mulimuli ane e AstraZeneca.O se fa'agata PARP, fa'alavelaveina le poly ADP ribose polymerase (PARP), ose enzyme o lo'o a'afia i le toe fa'aleleia o DNA. E galue e fa'asagatau i kanesa i tagata e iai fa'aliliuga BRCA1 po'o BRCA2, e aofia ai ma'i ovarian, susu, ma prostate.Ia Tesema 2014, na faʻatagaina le olaparib mo le faʻaaogaina o se sui e tasi e le EMA ma le FDA.O le fa'atagaga a le FDA o lo'o i totonu mo le germline BRCA mutated (gBRCAm) o le kanesa ovarian maualuga lea na maua ai le tolu pe sili atu laina muamua o le chemotherapy.
