2,3-Dihydrobenzofuran CAS 496-16-2 Ramelteon Fa'asa'o Tulagalua >99.0% (GC)
Ta'ita'i Gaosi ma Fa'atau oloa, Intermediates a Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-tasi CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
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| Igoa Vailaau | 2,3-Dihydrobenzofuran |
| Synonyms | Coumaran;2,3-Dihydro-2,3-Benzofuran;2,3-Dihydrobenzo[b]furan;2,3-Dihydro-1-Benzofuran |
| Numera CAS | 496-16-2 |
| CAT Numera | RF2884 |
| Tulaga Fa'asoa | I Fa'atauga, Gaosi Gaosi 20 Tone i le Masina |
| Fuafua mole | C8H8O |
| Molecular Weight | 120.15 |
| Lisi Lisi | -21℃ |
| Fa'apuna | 188.0~189.0 ℃ (malamalama) |
| Mata'imu | 66℃ |
| Solubility | Ava: Solu |
| Mata'utia Fa'amatalaga | Fa'aitaita |
| TSCA | Ioe |
| HS Code | 29329995 |
| Temp. | Faamaufa'ailoga i le mago, potu vevela |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Suavai manino e leai se lanu pe samasama |
| Mama / Suʻesuʻega Metotia | >99.0% (GC) |
| Vai (saunia e Karl Fischer) | <0.50% |
| Malosi (20℃) | 1.065~1.085 |
| Fa'asinoga Fa'asinomaga n20/D | 1.547~1.551 |
| Le mama nofofua | <0.50% |
| Aofa'i Fa'aleaga | <1.00% |
| Proton NMR Alaleo | E tusa ma le Fauga |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | Pharmaceutical Intermediate of Ramelteon (CAS: 196597-26-9) |
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2,3-Dihydrobenzofuran (CAS: 496-16-2) o loʻo faʻaaogaina lautele i le tuʻufaʻatasia o mea faʻapipiʻi tricyclic ma o loʻo avea foʻi ma mea faʻapitoa mo le faʻaogaina o nisi vailaʻau taua.2,3-Dihydrobenzofuran e mafai ona faʻaaogaina e avea o se vaeluaga o Ramelteon (CAS: 196597-26-9).Ramelteon, faʻatauina e pei o Rozerem e Takeda Pharmaceuticals North America, o se sui moe e filifili faʻatasi i le MT1 ma le MT2 faʻafeiloaʻi i le suprachiasmatic nucleus (SCN), nai lo le fusifusia i GABAA receptors, e pei o vailaʻau e pei o le zolpidem.Peitai e foliga mai e le faatelevaveina le moe po o le tele o le moe e maua e le tagata.Ua fa'amaonia e le US Food and Drug Administration (FDA) mo le fa'aoga umi.E le faʻaalia e Ramelteon soʻo se faʻamaufaʻailoga taua i GABAA faʻafeiloaʻi, lea e fesoʻotaʻi ma faʻalavelave popole, myorelaxant, ma aʻafiaga amnesic.E le pei o le tele o togafitiga o le le mautonu o loʻo faʻatatau i le GABA (g-aminobutyric acid) faʻafesoʻotaʻi faʻalavelave, ramelteon o se agonist o le melatonin receptor.Aemaise lava, e maualuga lona filifilia mo le MT1 ma le MT2 subtypes, lea na aʻafia i le tausiga o circadian rhythms, i luga o le MT3 receptor nafa ma isi galuega melatonin.2,3-Dihydrobenzofuran o loʻo faʻaaogaina foi i le faʻapipiʻiina o vailaʻau antitumor benzofuran sulfonylureas, HIV protease inhibitor amino acid hydroxyethylenesulfonyl, matrix metalloproteinase inhibitor aryl sulfinyl isoxime hydroxamic acid, ma isi.
