2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5 Remdesivir Intermediate COVID-19
Gaosi Fa'atauga Fa'atauga Remdesivir ma Feso'ota'i Fesoota'iga ma le Tulaga Maualuga
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Igoa Vailaau | 2,3,5-Tri-O-benzyl-D-ribonolactone |
Synonyms | 2,3,5-Tri-O-Benzyl-D-Ribono-1,4-Lactone;Remdesivir Intermediate |
Numera CAS | 55094-52-5 |
CAT Numera | RF-PI301 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
Fuafua mole | C26H26O5 |
Molecular Weight | 418.49 |
Lisi Lisi | 54.0-55.0 ℃ |
Tulaga Teuteu | Temperature Potu |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Samasama po'o Pa'epa'e Malosi |
Solubility | Solu i le CH2Cl2 ma le le mafai ona solu i le H2O |
NMR ma MS | E tatau ona Tausi |
Fa'ailoaga | IR ma TLC |
Susū | ≤1.0% |
Toega i luga o le mumu | ≤0.50% |
So'o se Fa'aleaga Ta'ito'atasi | ≤0.50% |
Metala mamafa | ≤50ppm |
HPLC (210nm) | ≥99.0% |
HPLC (ELSD) | ≥99.0% |
Tulaga Su'ega | Pisinisi Tulaga |
Fa'aoga | Vaitaimi ole Remdesivir (CAS 1809249-37-3) |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
2,3,5-Tri-O-benzyl-D-ribonolactone (CAS 55094-52-5) o se Remdesivir intermediate.Remdesivir (CAS 1809249-37-3) ose vailaʻau antiviral fou i le vasega o nucleotide analogs, faʻaaogaina i togafitiga ole COVID-19.Remdesivir (GS-5734) o se tala fou antiviral nucleoside analogue e taofia murine hepatitis virus (MHV) ma tutusa EC50 pei SARS-CoV ma MERS-CoV.Coronaviruses (CoVs) o faʻamaʻi lelei, RNA faʻapipiʻi tasi e aʻafia ai le tele o ituaiga o manu.I tagata, o CoVs na iloa e masani ona mafua ai le malulu ma le niumonia seia oʻo ina aliaʻe le maʻi tigaina o le manava coronavirus (SARS-CoV) i le 2002 ma Sasaʻe Tutotonu o le respiratory syndrome coronavirus (MERS-CoV) i le 2012 mai faʻamaʻi faʻamaʻi.Remdesivir o le monophosphoramidate prodrug o le C-adenosine nucleoside analogue GS-441524.I le tuai o le fai'ai tumo (DBT) sela ua pisia i le MHV, GS-5734 taofia MHV sili atu le malosi nai lo GS-441524, faatasi ai ma le GS-5734 EC50 o le 0.03 M. E le gata i lea, EC50 tau na fuafuaina ina ua uma togafitiga ma GS-441524 ma GS-441524. i le SARS-CoV- ma le MERS-CoV-a'afia muamua tagata ea ea epithelial cell (HAE) aganuu.