3-Methyl-6-Nitroindazole CAS 6494-19-5 Mama>98.0% (HPLC)
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Igoa Vailaau | 3-Methyl-6-Nitroindazole |
Synonyms | 3-Methyl-6-Nitro-1H-Indozole;6-Nitro-3-Methylindazole |
Numera CAS | 6494-19-5 |
CAT Numera | RF2682 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C8H7N3O2 |
Molecular Weight | 177.16 |
Lisi Lisi | 184.0 i le 188.0 ℃ |
Fa'apuna | 384.9±22.0℃ |
Malosi | 1.437 |
Solubility | Chloroform (La'iti), Methanol (La'iti) |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Samasama Malamalama i Samasama Pogisa e Pa'u Enaena i Crystal |
Mama / Suʻesuʻega Metotia | >98.0% (HPLC) |
Lisi Lisi | 184.0 i le 188.0 ℃ |
Ma'imau ile Fa'amago | <1.00% |
Aofa'i Fa'aleaga | <2.00% |
Alaleo Infrared | E tusa ma le Fauga |
Proton NMR Alaleo | E tusa ma le Fauga |
Tulaga Su'ega | Pisinisi Tulaga |
Fa'aoga | Pharmaceutical Intermediate;Pazopanib Hydrochloride Intermediate |
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3-Methyl-6-Nitroindazole (CAS: 6494-19-5) o loʻo faʻaaogaina e avea ma Pharmaceutical Intermediate.E mafai ona faʻaaogaina e avea o se vaeluaga ole Pazopanib Hydrochloride (CAS: 635702-64-6).Pazopanib Hydrochloride o lo'o su'esu'eina ma fa'atupuina e le GlaxoSmithKline, o se fa'agata fa'atupu totoga o le gutu lea e ono fa'alavelave ai le ola tumo ma'a'a ma le tuputupu a'e o va'a toto fou e mana'omia.Fa'atatau i le vascular endothelial growth factor receptor (VEGFR), e galue e ala i le taofiofia o le angiogenesis o le toto tumo.E fetaui lelei mo le gasegase o le tino (su'esu'eina o sela o le kanesa i totonu o tubules), sarcoma o mea vaivai (STS), kanesa ovarian epithelial ma le kanesa o le mama sela (NSCLC).Na faʻamaonia e le US Food and Drug Administration (FDA) ia Oketopa 19, 2009 o Pazopanib Hydrochloride (igoa fefaʻatauaʻiga Votrient) o loʻo lisiina, o le lona ono o togafitiga faʻamaonia o le kanesa fatugaʻo talu mai le 2005.