4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8 Mama >99.0% (HPLC) Aprepitant Intermediate Factory
Ta'ita'i gaosi oloa ma fa'atau oloa
Tulaga o Aprepitant (CAS: 170729-80-3)
4-Benzyl-2-Hydroxymorpholin-3-tasi CAS 287930-73-8
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol CAS 127852-28-2
Please contact: alvin@ruifuchem.com
| Igoa Vailaau | 4-Benzyl-2-Hydroxymorpholin-3-tasi |
| Synonyms | 4-Benzyl-2-Hydroxy-Morpholin-3-tasi;2-Hydroxy-4-(Phenylmethyl)-3-Morpholinone;Aprepitant Le mama 48;Fosaprepitant Le mama 23;Aprepitant Intermediate Ⅱ |
| Numera CAS | 287930-73-8 |
| CAT Numera | RF2660 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C11H13NO3 |
| Molecular Weight | 207.23 |
| Lisi Lisi | 134.0 i le 138.0 ℃ |
| Fa'apuna | 441.7±45.0℃ |
| Malosi | 1.292±0.06 g/cm3 |
| Solubility i le Vai | DMSO (La'iti), Methanol (Teisi, Fa'avevela) |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'u Pa'epa'e Pa'epa'e |
| Mama / Suʻesuʻega Metotia | >99.0% (HPLC) |
| Lisi Lisi | 134.0 i le 138.0 ℃ |
| Vai (saunia e Karl Fischer) | <0.50% |
| Toega i luga o le mumu | <0.20% |
| Aofa'i Fa'aleaga | <1.00% |
| Proton NMR Alaleo | E tusa ma le Fauga |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | Intermediate of Aprepitant (CAS: 170729-80-3) Antiemetic Drug |
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4-Benzyl-2-Hydroxymorpholin-3-one (CAS: 287930-73-8), o se vaeluagalemu o Aprepitant (CAS: 170729-80-3), faʻaaogaina e avea ma vailaʻau faʻamaʻi.O le Aprepitant o le neurokinin-1 (NK-1) e fa'afeagai le tali atu ma e auai i le togafitiga o le pua'i i le taimi o le chemotherapy o le kanesa.Na muamua fa'atupuina lelei e le Kamupani Merck (Siamani).Ia Mati 2003, na faʻamaonia ai e le US Food and Drug Administration le faʻaaogaina mo togafitiga o le faʻasuati o le chemotherapy.O lenei oloa e maualuga lona fa'atasiga filifilia i tagata soifua ae e maualalo le feso'ota'iga i le serotonin, dopamine ma le glucocorticoid receptor affinity.Aprepitant, pe a tuʻufaʻatasia ma le 5-HT3 inhibitors receptors (e pei o le ondansetron hydrochloride) ma le corticosteroid dexamethasone, e mafai ona faʻaitiitia atili ai le faʻamaʻi pipisi o le cisplatin ma (poʻo le) tuai.O le fa'aogaina o lenei vaila'au e mafai ona i ai se aafiaga puipuia.
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