Afatinib CAS 439081-18-2 Mama>99.5% (HPLC) Fale Fa'ailoga Ata

Afatinib CAS 439081-18-2 Mama>99.5% (HPLC) Falegaosimea

Fa'amatalaga Puupuu:

Igoa Vailaau: Afatinib

upu uiga tutusa: BIBW2992

CAS: 439081-18-2

Mama: >99.5% (HPLC)

Fa'aaliga: Pa'u Pa'epa'e Pa'epa'e

E-Mail: alvin@ruifuchem.com

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Fa'amatalaga:

Ruifu Sapalai Vailaau Fa'alava ole Afatinib
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N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy)quinazolin-4-AmineCAS 314771-88-5

Meatotino tau vailaau:

Igoa Vailaau	Afatinib
Synonyms	BIBW2992;BIBW-2992;BIBW2992 Fa'avae Sa'oloto;Tomtovok;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(Dimethylamino)ae-2-Enamide
Numera CAS	439081-18-2
CAT Numera	RF-PI2033
Tulaga Fa'asoa	I Fa'atauga, Oloa Fua e O'o i Tone
Fuafua mole	C24H25ClFN5O3
Molecular Weight	485.94
Solubility	Solu i le DMSO
Malosi	1.380
Fa'ailoga	Ruifu Chemical

Fa'amatalaga:

Aitema	Fa'amatalaga
Fa'aaliga	Pa'u Pa'epa'e Pa'epa'e
Fa'ailoaga	HPLC, NMR
Mama / Suʻesuʻega Metotia	>99.5% (HPLC)
Lisi Lisi	100.0~102.0 ℃
Ma'imau ile Fa'amago	<0.50%
Toega i luga o le mumu	<0.20%
Aofa'i Fa'aleaga	<0.50%
Metala mamafa	≤20ppm
NMR Alaleo	E tusa ma le Fauga
Tulaga Su'ega	Pisinisi Tulaga
Ola Fa'asa	24 masina pe a teu lelei
Fa'aoga	API;Afatinib;Afatinib Dimaleate;NSCLC

Paket & Teuina:

afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau

Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu

Tulaga lelei:

FAQ:

Talosaga:

Afatinib, lea e lauiloa foi o le BIW-2992, (CAS: 439081-18-2) o le lona lua-tupulaga malosi ma le le mafai ona toe faʻafoʻiina o le inhibitor lua o le epidermal growth factor receptor (EGFR) ma le tagata epidermal growth factor receptor 2 (HER2) tyrosine kinase, fausia e Boehringer Ingelheim, Siamani.E mafai ona faʻalavelaveina le gaioiga o le tyrosine kinase e ala i le faia o le tali a Michael ma le vaega thiol o le cysteine i le tulaga 797 o le EGFR.I le aso 12 o Iulai, 2013, na avea ai ma vailaʻau fou mo le kanesa o le mama sela laiti na faʻamaonia e le US FDA i lalo o le igoa tau fefaʻatauaʻiga o Gilotrif.O lenei vailaʻau o se laulau.E faʻaaogaina mo togafitiga o tagata mamaʻi na maua i le metastatic non-small cell lung cancer (NSCLC) faʻatasi ai ma le leiloa o le 19th exon poʻo le L858R mutation i le 21th exon o le tumor epidermal growth factor receptor (EGFR) faʻamaonia i le faʻaaogaina o le pusa faʻamaonia. e le FDA.E aoga foi le vaila'au i le togafitia o tagata mama'i HER2-lelei ma le kanesa o le susu.Afatinib e aofia i se vasega o vailaʻau e taʻua o tyrosine kinase inhibitors.Tyrosine kinase inhibitors ua mamanuina e poloka ai le gaioiga a se enzyme patino e taʻua o tyrosine kinase.O lenei enzyme e tele sona sao i le gaioiga o sela, ma e malosi i le faʻalauiloaina o le tuputupu aʻe ma le alualu i luma.Afatinib e galue e faʻalavelaveina le gaioiga o ituaiga e lua o tyrosine kinases: epidermal growth factor receptor (EGFR) ma Her2, lea e "faʻaalia" e le tele o ituaiga o kanesa.E ala i le polokaina o galuega a nei tyrosine kinases, e mafai e Afatinib ona taofia sela o le kanesa mai le vaeluaina ma le tuputupu aʻe.