Afatinib Dimaleate CAS 850140-73-7 Mama >99.5% (HPLC) API

Afatinib Dimaleate (CAS: 850140-73-7), o le masima masima dimaleate o afanitib, o se vailaʻau faʻamaʻi faʻamaʻi e maua.Afatinib Dimaleate o se faʻalavelave EGFR aiga e le mafai ona faʻaaogaina ma IC50s o 0.5 nM, 0.4 nM, 10 nM ma 14 nM mo EGFRwt, EGFRL858R, EGFRL858R / T790M ma HER2, faasologa.Afatinib Dimaleate o loʻo faʻaalia mo togafitiga muamua o tagata mamaʻi e maua i le metastatic non-small cell lung cancer (NSCLC) o latou tuma e iai le epidermal growth factor receptor (EGFR) exon 19 deletions poʻo le exon 21 (L858R) suiga suiga e pei ona iloa e se FDA- suega faamaonia.I aso ua tuanaʻi, o togafitiga faʻatasi ma le faʻaogaina o le chemotherapy doublet regimen e faʻavae i luga o le platinum na faʻatatau i togafitiga laina muamua mo tagata mamaʻi uma ma le NSCLC.Ae ui i lea, o faʻamaoniga faʻaalia ua faʻaalia ai subpopulations lea e sili atu ona aoga togafitiga faʻatatau, e mafua ai le atinaʻeina o vailaʻau faʻapitoa.Afatinib Dimaleate na atiaʻe e Boehringer Ingelheim Pharmaceuticals, Afatinib Dimaleate na faʻamaonia e le FDA i le 2013 o se vailaʻau matuaoti i lalo o le igoa tau fefaʻatauaʻiga Gilotrif.Afatinib Dimaleate o loʻo faʻapipiʻiina faʻamalosi e faʻaaoga ai metotia masani.Afatinib Dimaleatee le gata ina malosi e tetee atu i suiga o le EGFR e taulaʻi i tupulaga muamua TKIs pei o le erlotinib poʻo le gefitinib, ae faʻapea foʻi ma suiga e pei o le T790M e le faʻaogaina i nei togafitiga masani.Ona o lana gaioiga faaopoopo faasaga ia Her2, o loʻo suʻesuʻeina mo le kanesa o le susu faʻapea foʻi ma isi faʻamaʻi EGFR ma Her2.