Afatinib Dimaleate Intermediate CAS 314771-76-1 Mama>99.0% (HPLC) Fa'aaliga Fa'aalia ile Falegaosimea

Afatinib Dimaleate Intermediate CAS 314771-76-1 Mama >99.0% (HPLC) Falegaosimea

Fa'amatalaga Puupuu:

Igoa Vailaau: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Mama: >99.0% (HPLC)

Fa'aaliga: Samasama Malamalama i le Pata Samasama

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Fa'amatalaga Oloa

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Fa'amatalaga:

Ruifu Sapalai Vailaau Fa'alava ole Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-tasi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy)quinazolin-4-AmineCAS 314771-88-5

Meatotino tau vailaau:

Igoa Vailaau	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy)quinazoline-4,6-Diamine
Synonyms	N4-(3-Chloro-4-Fluorophenyl)-7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Afatinib Le mama B;Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl;Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Numera CAS	314771-76-1
CAT Numera	RF-PI2028
Tulaga Fa'asoa	I Fa'atauga, Gaosiga Gafatia 100MT/Tausaga
Fuafua mole	C18H16ClFN4O2
Molecular Weight	374.8
Fa'apuna	559.0±50.0℃
Malosi	1.473±0.060g/cm3
Fa'ailoga	Ruifu Chemical

Fa'amatalaga:

Aitema	Fa'amatalaga
Fa'aaliga	Samasama moli i le Pata Samasama
Fa'ailoaga	Ole Taimi Fa'atumauina ole Tulaga Autu ile HPLC e Tatau Ona Fa'atatau ile Fa'atonu
Mama / Suʻesuʻega Metotia	>99.0% (HPLC)
Ma'imau ile Fa'amago	<0.50%
Toega i luga o le mumu	<0.20%
Le mama nofofua	<0.50%
Aofa'i Fa'aleaga	<1.00%
Metala mamafa (pei o le Pb)	≤20ppm
Tulaga Su'ega	Pisinisi Tulaga
Fa'aoga	Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

Paket & Teuina:

afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau

Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu

Tulaga lelei:

FAQ:

Talosaga:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) o se vaeluaga ole Afatinib Dimaleate (CAS: 850140-73-7).Afatinib o le lona lua-tupulaga malosi ma le mafai ona toe faʻaogaina le inhibitor lua o le epidermal growth factor receptor (EGFR) ma le tagata epidermal growth factor receptor 2 (HER2) tyrosine kinase, na atiina ae e Boehringer Ingelheim, Siamani.E mafai ona faʻalavelaveina le gaioiga o le tyrosine kinase e ala i le faia o le tali a Michael ma le vaega thiol o le cysteine i le tulaga 797 o le EGFR.Galuega: 1. E pei o Lapatinib ma Neratinib, Afatinib o se polotini kinase inhibitor lea e le mafai foi ona faʻalavelaveina tagata epidermal growth factor receptor 2 (Her2) ma epidermal growth factor receptor (EGFR) kinases.2. O le Afatinib e le gata ina malosi i suiga o le EGFR o loʻo faʻatatau i TKI o augatupulaga muamua e pei o le erlotinib poʻo le gefitinib, ae faʻapea foʻi ma suiga e pei o le T790M e le faʻaogaina i nei togafitiga masani.Ona o lana gaioiga faaopoopo faasaga ia Her2, o loʻo suʻesuʻeina mo le kanesa o le susu faʻapea foʻi ma isi faʻamaʻi EGFR ma Her2.3. O le Afatinib o se vaila'au mo le laina muamua o togafitiga o tagata mama'i e eseese ituaiga metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC).E galue e pei o se inhibitor covalent e le mafai ona toe fa'afo'isia o le receptor tyrosine kinases epidermal growth factor receptor (EGFR) ma le erbB-2 (HER2).