Baloxavir Marboxil CAS 1985606-14-1 API Falegaosi Mea Maualuluga

Fa'amatalaga Puupuu:

Igoa vaila'au: Baloxavir Marboxil

CAS: 1985606-14-1

Fa'aaliga: Pa'epa'e i le Pa'epa'e Pa'epa'e

Su'ega: 98.0%~102.0%

I le togafitiga o le Influenza A ma le Influenza B Infections

Fa'afeso'ota'i: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Fa'amatalaga Oloa

Oloa Fa'atatau

Faailoga o oloa

Fa'amatalaga:

Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Baloxavir Marboxil (CAS: 1985606-14-1) faʻatasi ai ma tulaga maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Baloxavir Marboxil,Please contact: alvin@ruifuchem.com

Meatotino tau vailaau:

Igoa Vailaau	Baloxavir Marboxil
Synonyms	BXM;S-033188
Numera CAS	1985606-14-1
Tulaga Fa'asoa	I Fa'atauga, Oloa Fua e O'o i le selau Kilograms
Fuafua mole	C27H23F2N3O7S
Molecular Weight	571.55
Malosi	1.57±0.10g/cm3
Solubility	Solu i le DMSO
Teuga umi	Taofi umi i le -20℃
COA & MSDS	Avanoa
Amataga	Shanghai, Saina
Fa'ailoga	Ruifu Chemical

Fa'amatalaga:

Aitema	Fa'amatalaga
Fa'aaliga	Pa'epa'e i le Pa'epa'e Pa'epa'e
Fa'ailoaga	O le IR Spectrum e fetaui ma fa'amaumauga masani Ole taimi fa'atumauina e fetaui ma tulaga fa'asino
Suavai (e KF)	≤1.0%
Ma'imau ile Fa'amago	≤1.0%
Toega i luga o le mumu	≤0.50%
Metala mamafa	≤20ppm
Mea Fa'atatau
Fa'aleaga Tagata Ta'ito'atasi Maualuga	≤0.50%
Aofa'i Fa'aleaga	≤1.0%
Lapo'a La'au	D90 pasi 150um
Chiral Mama	≥99.0%
Mama	≥99.0%
Su'ega	98.0%~102.0%
Solvents totoe	Usitaia Manaoga ICH
Va'a	La'uina ma le pusa aisa
Tulaga Su'ega	Pisinisi Tulaga
Fa'aoga	API, ile togafitiga ole Influenza A ma le Influenza B

Paket & Teuina:

afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Taofi mau le atigipusa ma teu i totonu o se faleteuoloa malulu, mago (2~8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.

Tulaga lelei:

FAQ:

1985606-14-1 - Talosaga:

Baloxavir Marboxil (CAS: 1985606-14-1, BXM, S-033188, Xofluza) o se vailaʻau faʻamaʻi faʻamaʻi na atiaʻe e Shionogi Co., o se kamupani vailaʻau Iapani ma Roche mo le togafitia o faʻamaʻi pipisi A ma le influenza B.O le vailaʻau na faʻatagaina muamua mo le faʻaaogaina i Iapani ia Fepuari 2018 ma faʻamaonia e le FDA ia Oketopa 24, 2018 mo togafitiga o le faʻamaʻi faʻalavelave faʻalavelave i tagata mamaʻi 12 tausaga ma matutua atu o loʻo faʻaalia mo le sili atu i le 48 itula Faʻailoga.Baloxavir marboxil, o le cap-endonuclease inhibitor, ei ai se faiga tulaga ese o gaioiga pe a faatusatusa i le neuraminidase inhibitor vasega o loʻo i ai nei o loʻo faʻaaogaina e togafitia ai faʻamaʻi pipisi.Baloxavir Marboxil ose vaila'au fa'ama'i fa'ama'i fou fa'atasi ai ma faiga fou fa'atino.O le Baloxavir Marboxil o le vailaʻau o le Baloxavir Acid (S-033447) e mafai ona faʻalavelaveina le endonuclease faʻalagolago i le pulou i totonu o le polymerase PA subunit o faʻamaʻi pipisi A ma B, e taʻitaʻia ai le faʻaogaina o le RNA transcription ma le toe faia.Baloxavir ua uma ona suʻesuʻeina mo lona gafatia e togafitia ai le COVID-19 ae leai se aoga faʻamaonia na matauina.

1985606-14-1 - Mechanism of Action:

O le Baloxavir Marboxil o se vailaʻau faʻamaʻi faʻamaʻi, faʻapitoa, o se inhibitor enzyme e faʻatatau i le faʻaogaina o le endonuclease faʻalagolago i le siama o le influenza, o se tasi o gaioiga a le siama polymerase lavelave.Aemaise lava, e taofia ai se faiga e taʻua o le puʻeina o le pulou, lea e maua mai ai e le siama ni mea pupuu, faʻapipiʻi faʻamaufaʻailoga mai le host cell RNA transcripts, lea e faʻaaogaina mo le polymerase-catalyzed synthesis o ana mRNA viral manaʻomia.O se vaega o le polymerase e fusifusia i le au talimalo muamua-mRNAs i o latou 5' pulou, ona faʻatupuina lea e le polymerase's endonuclease gaioiga lona vaeluaina "pe a uma le 10-13 nucleotides".E pei o lea, o lona masini e ese mai le neuraminidase inhibitors pei ole Oseltamivir ma Zanamivir.

1985606-14-1 - Pharmacokinetics:

Baloxavir Marboxil o se fa'ailo filifilia o le influenza cap-dependent endonuclease lea e taofia ai le galuega polymerase ma o le mea lea o le influenza virus mRNA replication 5, 3. Ua faʻaalia le gaioiga faʻamalosi e faasaga i faʻamaʻi pipisi o le influenza A ma le B, e aofia ai faʻamaʻi e tetee atu i vailaʻau faʻamaʻi o loʻo iai nei 1. O lenei vailaʻau. fa'alavelaveina se enzyme e mana'omia mo le toe faia o fa'ama'i, fa'apea vave ona togafitia fa'ama'i fa'ama'i 5, Fa'ailoga ma fa'aitiitia fa'ailoga e feso'ota'i ma fa'ama'i.E tasi le fua o lenei vaila'au na fa'aalia e sili atu nai lo le placebo i le fa'amaloloina o fa'amaoniga o le fulū ma sili atu i le oseltamivir ma le placebo fualaau i taunu'uga virologic (fa'ailogaina i le fa'aitiitia o viral load).

1985606-14-1 - Fa'ailoga:

O le Baroxavir e talafeagai mo tagata mama'i ≥ 12 tausaga le matutua o lo'o mafatia i le fa'amaʻi pipisi e le faʻalavelave ma o latou faʻamaoniga e le sili atu i le 48 itula.E tatau ona gauai atu i tapulaʻa o vailaʻau: o le siama o le influenza e suia i le taimi, ma e iai mea e pei o le virus type ma subtype.O le taimi lava e suia ai le tete'e o vaila'au o le siama ma le pathogenicity o le siama, e mafai ona fa'avaivaia le aoga o vaila'au antiviral.Pe a filifili pe ave le basalovir dipivoxil, o faʻamatalaga avanoa e uiga i le maʻaleʻale o le faʻamaʻi faʻamaʻi i le lotoifale e tatau ona mafaufau i ai.

1985606-14-1 - Fa'aoga:

Baloxavir Marboxil o se vailaʻau faʻamaʻi, o se vailaʻau faʻamaʻi, e ave e pei o se fualaʻau fua e tasi, e ala i le gutu, e tagata taʻitoʻatasi e 12 tausaga le matutua pe sili atu, o loʻo faʻaalia faʻamaoniga o lenei faʻamaʻi mo le le sili atu i le 48 itula. baloxavir marboxil fa'atino pe a uma le 48 itula e le'i fa'ata'ita'iina.

1985606-14-1 - Fa'asalaga:

Baloxavir Marboxil e le tatau ona faʻatasi ma meaʻai susu, meainu faʻamalosia le calcium, poʻo le laxatives, antacids, poʻo mea faʻapipiʻi gutu e iai le calcium, iron, magnesium, seleni, alumini poʻo le zinc.

1985606-14-1 - Aafiaga itu:

O a'afiaga masani pe a mae'a le fa'atonuga tasi o le baloxavir marboxil e aofia ai le manava manava, bronchitis, malulu masani, ulu ulu, ma le nausea.O mea leaga na tutupu na lipotia i le 21% o tagata na mauaina le baloxavir, 25% oi latou na mauaina placebo, ma le 25% o Oseltamivir.

1985606-14-1 - Sauniuniga:

Pateni Iapani JP6212678 na lipotia mai le auala faʻapipiʻi o Baloxavir Marboxil.3, 4-difluorobenzoic acid na faʻaaogaina e fai ma mea mata e tali atu ai ma le DMF i lalo o le gaioiga a le LDA e maua ai le 2-formyl-3, 4-difluorobenzoic acid.Ona fausia ai lea o le thioacetal ma le thiophenol, ona faʻaitiitia lea ma vavae ese i le borane e maua ai le 2-phenylthiomethyl -3, 4-difluorob, 8-difluorodibenzo [B, e] thiazepine -11 (6H) -one, ma mulimuli ane le fasi vaega autu o le thiazepine. 7, 8-difluoro-6,11-dihydrodibenzo [B, e] thiazepine -11-alcohol e maua i lalo o le faʻaitiitia o le sodium borohydride.Fa'aaogā le 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid e tali atu ai i le tert-butyl formate pe a uma ona fa'amama e maua ai le 3-(benzyloxy)-1-((tert-butoxycarbonyl) amino) -4-oxo -1, 4-dihydropyridine-2-methyl formate hydrate, ona sosoo ai lea ma le 2-(2, 2-dimethoxyethoxy) ethylamine e maua ai le tali o le urethane, ona faʻataʻamilomilo lea i lalo o le gaioiga o le methanesulfonic acid e maua ai le 7-(benzyloxy) -3, 4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyridino [2,1-f][1,2,4] triazine -6, 8-dione hemihydrate, ona condensed i (R) -tetrahydrofuran -2-formic acid, ona crystallized ma foia, ona aveese lea o le vaega auxiliary chiral e maua ai le kiral matua mama mole (R) -7- (benzyloxy) -3,4,12, 12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyrido [2,1-f][1,4] Triazine-6, 8-dione.Ona faʻaaogaina lea o le mole mama mama matua e fesuiaʻi ma le n-hexanol i lalo o le gaioiga a Grignard reagent, ona faʻatasi ai lea ma le vaega autu o le thiazepine 7,8-difluoro-6, 11-dihydrodibenzo [B, e] thiazepine -11-alcohol docking. , ma mulimuli ane debutylation ma condensation ma methyl chloroformate e maua ai le oloa mulimuli Baloxavir Marboxil.