Bortezomib CAS 179324-69-7 Mama ≥99.0% (HPLC) API Falegaosi Mamalu Maualuga
Tuuina atu Bortezomib Fesoʻotaʻi Faʻatasi ma le Mama maualuga
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Bortezomib CAS 179324-69-7
| Igoa Vailaau | Bortezomib |
| Synonyms | Velcade, MG-341, PS-341 |
| Numera CAS | 179324-69-7 |
| CAT Numera | RF-API65 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C19H25BN4O4 |
| Molecular Weight | 384.24 |
| Lisi Lisi | 122.0~124.0 ℃ |
| Malosi | 1.214 |
| Fa'asino Upu | 1.564 |
| Solubility | Solu i Chloroform, DMSO, Ethanol ma Methanol |
| Maumau | Hygroscopic ma le susu maaleale |
| Tulaga Va'a | La'uina i lalo ole vevela ole ambient |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e po'o le Pa'epa'e Pa'epa'e |
| Mama / Suʻesuʻega Metotia | ≥99.0% (HPLC) |
| Ma'imau ile Fa'amago | ≤0.50% |
| Toega i luga o le mumu | ≤0.20% |
| Vaitaimi Mata | -41.0° ~ -46.0° |
| Uamea Mamafa | ≤20ppm |
| Acidity | 4.0~7.0 |
| Isomer | ≤0.50% |
| Le mama nofofua | ≤0.50% |
| Aofa'i Fa'aleaga | ≤1.0% |
| Solvents totoe | |
| Methanol | ≤0.30% |
| Dichloromethane | ≤0.05% |
| Hexane | ≤0.02% |
| Ethyl Acetate | ≤0.50% |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | API |
afifi: Fagu, Ato pepa alumini, Pusa Pusa, 25kg / Paʻu, poʻo e tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma le tuʻuina atu o Bortezomib (CAS: 179324-69-7) faʻatasi ai ma le maualuga, API.
Bortezomib, fa'atau atu i lalo o le igoa Velcade fa'atasi ma isi, o se vaila'au fa'ama'i-kanesa e fa'aaogaina e togafitia ai le tele o le myeloma ma le lymphoma cell mantle.Bortezomib na faʻamaonia mo le faʻaaogaina faafomaʻi i le Iunaite Setete i le 2003 ma i le Iuni a Europa i le 2004. O loʻo i luga o le Lisi o Vailaau Faʻapitoa a le Faalapotopotoga o le Soifua Maloloina a le Lalolagi.O le Bortezomib o le fa'atosina muamua o le proteasome ua fa'amaonia e le US FDA mo le tele o myeloma, o le kanesa toto.O se fa'alavelave toe fa'afo'isia o le 26S proteasome-o se paelo-pepepepe multiprotein particle o lo'o maua i totonu o le nucleus ma le cytosol o sela eukaryotic uma.O le Bortezomib o se inhibitor 26S proteasome filifilia ma malosi, o se mea e maua mai i le dipeptide acid boronic.O suʻesuʻega o sela o le kanesa pancreatic a le tagata e faʻaalia ai le Bortezomib e taofia le PKR-pei o le endoplasmic reticulum (ER) kinase ma faʻaleleia le faʻalavelave ER, e oʻo atu ai i le apoptosis.
