Brigatinib CAS 1197953-54-0 Mama >99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Brigatinib (AP-26113) (CAS: 1197953-54-0) faʻatasi ai ma tulaga maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Brigatinib,Please contact: alvin@ruifuchem.com
Igoa Vailaau | Brigatinib |
Synonyms | AP26113;AP-26113;5-Chloro-N4-[2-(Dimethylphosphinyl)phenyl]-N2-[2-Methoxy-4-[4-(4-Methyl-1-Piperazinyl)-1-Piperidinyl]phenyl]-2,4-Pyrimidinediamine |
Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
Numera CAS | 1197953-54-0 |
Fuafua mole | C29H39ClN7O2P |
Molecular Weight | 584.09 g/mol |
Lisi Lisi | >203℃(Tes.) |
Malosi | 1.31±0.10g/cm3 |
COA & MSDS | Avanoa |
Amataga | Shanghai, Saina |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga | I'uga |
Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e | E usitaia |
Mama / Suʻesuʻega Metotia | >99.0% (HPLC) | 99.26% |
Max.Le mama nofofua | <1.00% | 0.25% |
Ma'imau ile Fa'amago | <1.00% | 0.27% |
Alaleo Infrared | Ia ogatasi ma le Fauga | E usitaia |
1H NMR Alaleo | Ia ogatasi ma le Fauga | E usitaia |
Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga |
afifi:Fa'ato'aga Fa'alili, Ato pepa alumini, 25kg/Cardboard Drum, pe tusa ai ma mana'oga o tagata fa'atau.
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Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Maketi Autu?Faʻatau atu i maketi i totonu o le atunuʻu, Amerika i Matu, Europa, Initia, Korea, Iapani, Ausetalia, ma isi.
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Brigatinib (AP-26113) (CAS: 1197953-54-0) o se suʻesuʻega laʻititi laʻititi e faʻatatau i togafitiga o le kanesa o loʻo atiaʻe e le ARIAD Pharmaceuticals, Inc. Brigatinib o se vailaʻau faʻaaogaina e togafitia ai le kanesa e taofia ai le epidermal growth factor receptor (EGFR) ma anaplastic lymphoma kinase (ALK).Brigatinib o se agonist filifilia e faasaga i fesuiaiga o le EGFR e ese mai i foliga mutant vao.O le vailaʻau o loʻo faʻaalia ai foi le filifilia e faasaga i le ALK-EML4 fusion gene, o se itu taua o le fesuiaiga o parenchyma mama mama.O le Brigatinib e fa'atonuina mo tagata mama'i e iai ni kenera fa'apitoa ma pe a le tali atu le kanesa o le mama sela (NSCLC) i le pulega ma isi vaila'au.O le Brigatinib o loʻo faʻavasegaina o se iniseti kinase, o lona faiga o gaioiga e aofia ai le taofiofia o le gaioiga o polotini faʻalavelave e faʻaleleia ai le faʻateleina o sela o le kanesa.
Brigatinib (CAS: 1197953-54-0) o loʻo faʻatonuina mo tagata mamaʻi e iai ituaiga faʻapitoa ole NSCLC ua sosolo atu i vaega eseese o le tino i tagata na faia muamua togafitiga ma isi vailaʻau o le kanesa e pei ole Crizotinib, ma ua sili atu le leaga o latou tulaga. pe fa'ailoa mai ai ni fa'ailoga laiti o le fa'aleleia.O lo'o fa'ata'ita'iina i lalo ole su'esu'ega mo lona aoga ile kanesa ole mama sela (NSCLC) lea o lo'o fa'agaoioia ai le ALK ma e masani ona tupu suiga ole EGFP.
Brigatinib (AP-26113) (CAS: 1197953-54-0) o se faʻalavelave fou o le tyrosine kinase, faʻaalia le aoga tele i le ALK + metastatic NSCLC.I le aso 30 o Aokuso, 2016, na tuʻuina atu ai e le United States FDA le bugtinib e avea ma togafitiga faʻapitoa ma se vailaʻau seasea mo le ALK + NSCLC i tagata mamaʻi ua atiaʻe pe le mafai ona faʻafeiloaʻi Crizotinib, o le uluai augatupulaga ALK + NSCLC togafitiga.Tu'u le fa'amuamua i le lisi o le iloiloga o talosaga ma fa'ataga le tu'uina atu o fa'amaumauga o talosaga i se faiga fa'asolosolo.Na faamaonia e le FDA le Bugtinib ia Aperila 28, 2017, i lalo o le igoa tau fefaʻatauaʻiga Alunbrigtm.