Carvedilol CAS 72956-09-03 Mama>99.0% (HPLC)

Fa'amatalaga Puupuu:

Igoa vaila'au: Carvedilol

CAS: 72956-09-03

Mama: >99.0% (HPLC)

Fa'aaliga: Pa'u tioata Pa'epa'e

Fa'afeso'ota'i: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Auina imeli ia matou

Fa'amatalaga Oloa

Oloa Fa'atatau

Faailoga o oloa

Fa'amatalaga:

Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Carvedilol (CAS: 72956-09-03) faʻatasi ai ma tulaga maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Carvedilol,Please contact: alvin@ruifuchem.com

Fesoota'iga Intermediates:

Feso'ota'i Intermediates o Carvedilol

N-(2-(2-Methoxyphenoxy)ethyl)benzylamine Hydrochloride	CAS: 3246-03-5
2-(2-Methoxyphenoxy)ethylamine Hydrochloride Hydrate	CAS 64464-07-9
2-(2-Methoxyphenoxy)ethylamine	CAS 1836-62-0
4-(2,3-Epoxypropoxy)carbazole	CAS 51997-51-4
4-Hydroxycarbazole	CAS 52602-39-8
1,3-Cyclohexanedione	CAS 504-02-9
Carvedilol	CAS 72956-09-03
Carvedilol Phosphate Hemihydrate	CAS 610309-89-2

Meatotino tau vailaau:

Igoa Vailaau	Carvedilol
Synonyms	1-(9H-Carbazol-4-yloxy)-3-[[2-(2-Methoxyphenoxy)ethyl]amino]-2-Propanol;Tufuga;Cadilan;Carca;Cardivas;Carloc;Carvas;Carvedilol;Carvediol;Korek;DQ 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;BM-14190
Tulaga Fa'asoa	I Fa'atauga, GMP Commercial
Numera CAS	72956-09-3
Fuafua mole	C24H26N2O4
Molecular Weight	406.48 g/mol
Lisi Lisi	115.0 i le 119.0 ℃
Malosi	1.250±0.06g/cm3
Solubility i le Vai	E le mafai ona solu i le Vai
Solubility	Solu i le Methanol.Laititi Solu i le Ethanol, Eteru
Temp.	Nofoaga malulu ma mago (2~8℃)
COA & MSDS	Avanoa
Fa'ailoga	Ruifu Chemical

Fa'amatalaga:

Aitema	Tulaga Fa'atonu	I'uga
Fa'aaliga	Pa'u tioata Pa'epa'e	E usitaia
Ma'imau ile Fa'amago	≤0.50% (105℃ mo le 3 itula)	0.25%
Toega i luga o le mumu	≤0.10%	0.07%
Mea Fa'atatau
Aofa'i Fa'aleaga	≤0.50%	E usitaia
Le mama A	≤0.20%	E usitaia
Le mama C	≤0.02%	E usitaia
So'o se isi mea leaga ta'ito'atasi	≤0.10%	E usitaia
Metala mamafa (Pb)	≤10ppm	<10ppm
Mama / Suʻesuʻega Metotia	>99.0% (HPLC)	99.72%
Alaleo Infrared	E tusa ma le Fauga	E usitaia
Fa'ai'uga	Ua fa'ata'ita'iina le oloa ma fa'amalieina fa'amatalaga

Paket/Teuga/Va'a:

afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Teu i totonu o se atigipusa tapuni.Teu i totonu o se faleteuoloa malulu, mago (2 ~ 8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.

Tulaga lelei:

Lava Malosiaga: Lava fale ma tekinisia

Au'aunaga Fa'apolofesa: Au'aunaga fa'atau e tasi

OEM Package: Fa'ailoga fa'apitoa ma fa'ailoga e maua

Fa'atauga Anapogi: Afai i totonu o fa'atauga, e tolu aso fa'aolaina fa'amaonia

Sapalai mautu: Tausia fa'atauga talafeagai

Lagolago Fa'atekinisi: Fa'atekonolosi fofo avanoa

Au'aunaga Fa'aaufa'atasi: E amata mai i le kalama i le kilokalama

Tulaga Maualuga: Faʻavae se faiga faʻamautinoaga lelei atoatoa

FAQ:

Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Tausaga Aafiaga?E sili atu nai lo le 15 tausaga o le poto masani i le gaosiga ma le auina atu i fafo o le tele o tulaga maualuga o vailaʻau faʻapitoa poʻo vailaʻau lelei.

Maketi Autu?Faʻatau atu i maketi i totonu o le atunuʻu, Amerika i Matu, Europa, Initia, Korea, Iapani, Ausetalia, ma isi.

Tulaga lelei?Tulaga maualuga, tau taugofie, auaunaga faʻapolofesa ma lagolago faʻapitoa, vave tuʻuina atu.

Tulaga leleiFaamautinoaga?Fa'atonuga lelei faiga.O meafaigaluega faʻapitoa mo suʻesuʻega e aofia ai le NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Fa'ata'ita'iga?O le tele o oloa e maua ai faʻataʻitaʻiga e leai se totogi mo le iloiloga lelei, o tau o felauaiga e tatau ona totogi e tagata faʻatau.

Fale Su'etusi?Fa'afeiloa'i su'etusi falegaosimea.Fa'amolemole fai se taimi vave.

MOQ?Leai MOQ.Laititi oka e talia.

Taimi Tiliva? Afai o loʻo i totonu o faʻatauga, e tolu aso e faʻamaonia le tuʻuina atu.

Felauaiga?E ala ile Express (FedEx, DHL), ile Air, ile Sea.

Pepa?A maeʻa le faʻatau atu auaunaga: COA, MOA, ROS, MSDS, ma isi mea e mafai ona tuʻuina atu.

Tulaga Fa'apitoa?E mafai ona tu'uina atu au'aunaga tu'ufa'atasiga fa'apitoa e fetaui lelei ma au su'esu'ega mana'oga.

Tulaga Totogi?Proforma invoice o le a lafo muamua pe a maeʻa le faʻamaoniga o le poloaiga, faʻapipiʻi a matou faʻamatalaga faletupe.Totogi e le T / T (Telex Transfer), PayPal, Western Union, ma isi.

72956-09-3 - Fa'amatalaga Saogalemu:

Laiti o lamatiaga N,Xn
Fa'amatalaga Tulaga 51/53-36/37/38-20/21/22
Faamatalaga Saogalemu 61-36-26
RIDADR UN 3077 9/PG 3
WGK Siamani 3
RTECS UA8670000
HazardClass AGA
Tu'ufa'atasiga III
Fa'amatalaga o Mea Mata'utia 72956-09-3(Fa'amatalaga o Mea Mata'utia)
Oona LD50 tuugutu ile taifau: > 1gm/kg

72956-09-3 -Talosaga:

Carvedilol (CAS: 72956-09-03) o se vasodilating beta-blocker aoga i le togafitiga o le toto maualuga ma le angina pectoris.I le faʻaopoopoga i le faʻaitiitia o le toto, o le carvedilol e faʻaitiitia ai le malosi o le toto e aunoa ma le tachycardia e masani ona tupu i vasodilators.O lo'o lipotia mai e fa'apalepale lelei ma a'afiaga fa'asao fatu.

O Carvedilol na faʻalauiloaina muamua i Peleseuma i le 1985. O lenei oloa e mafai ona poloka le faʻaogaina o le alpha ma le beta, e leai se gaioiga faʻapitoa, i le maualuga o faʻasalalauga faʻatasi ma le calcium antagonism.E i ai se aafiaga malosi o le polokaina o beta talipupuni, lea e mafai ona faʻalauteleina aʻa toto, faʻaitiitia le teteʻe lautele ma faʻaititia le toto toto, ma e itiiti sona aʻafiaga i le fatu ma le fatu fatu.E mafai ona faʻaaogaina le falemaʻi mo le maualuga maualuga ma le angina pectoris.

72956-09-3 - USP 35 Standard:

FAAMATALAGA

Carvedilol o lo'o iai le NLT 98.0% ma le NMT 102.0% o le C24H26N2O4, fa'atatau ile fa'amamago.

FAATINOGA

• A. Infrared absorption <197K>

• B. O le taimi fa'atumauina o le tumutumu tele o le fofo Fa'ata'ita'i e fetaui ma le vaifofo masani, e pei ona maua i le Su'ega.

SU'ESU'EGA

• Taualumaga

Puipuia: 2.72 g/L ole monobasic potassium phosphate.Fetuuna'i i le fa'ama'i phosphoric acid ile pH ole 2.0.

Vaega feavea'i: Acetonitrile ma Pa'u (31:69)

Fofo talafeagai fa'aoga: 0.05 mg/mL ta'itasi USP Carvedilol RS ma USP Carvedilol Fa'atatau Fa'atasi A RS ile vaega feavea'i.

Fofo masani: 0.04 mg/mL o le USP Carvedilol RS i le vaega Mobile

Fa'ata'ita'iga fofo: 0.04 mg/mL o Carvedilol ile vaega feavea'i

Faiga fa'akomepiuta

(Va'ai Chromatography <621>, Faiga Fa'atonu.)

Auala: LC

Su'esu'e: UV 240 nm

Koluma: 4.6-mm × 15-cm;5-µm fa'apipi'i L7

Malosi o le koluma: 55℃

Fuafuaga tafe: 1 mL/min

Taimi tamo'e: 60 min

Tele tui: 10 µL

Faiga talafeagai

Fa'ata'ita'iga: Fa'atonuga fa'aoga fofo

Mana'oga talafeagai

I'uga: NLT 4.0 i le va o le carvedilol ma le carvedilol e feso'ota'i fa'atasi A

Fa'ailoga fa'asu'u: NMT 1.5 mo le pito i luga o le carvedilol

Feso'ota'iga tulaga ese: NMT 2%

Iloiloga

Faʻataʻitaʻiga: Fofo masani ma Faʻataʻitaʻiga fofo

Fa'atatau le pasene ole carvedilol (C24H26N2O4) ile vaega ole fa'ata'ita'iga na ave:

I'uga = (rU/rS) × (CS/CU) × 100

rU=	tali pito maualuga o carvedilol mai le fofo Faʻataʻitaʻiga
rS=	tali pito i luga ole carvedilol mai le fofo masani
CS=	fa'atonuga ole carvedilol ile vaifofo masani (mg/mL)
CU=	fa'atonuga o le Carvedilol i le fa'ata'ita'iga fofo (mg/mL)

Tulaga talia: 98.0% -102.0% ile fa'amamago

LELEI

• Toega i luga o le mumu <281>: NMT 0.1% mai le 1 g

• Metala Mamafa, Metotia II <231>: NMT 10 ppm

• Organic Impurities, Fa'agasolo 1: [Fa'amatalaga-I luga o le fa'avae o mea le mama o lo'o i ai, faia a le Organic Impurities, Procedure 1 po'o Organic Impurities, Procedure 2. Organic Impurities, Procedure 2 e fautuaina pe a fai le carvedilol related compound F o se tulaga le mama.]

Fa'asagaga ma Fe'avea'i vaega: Saunia e pei ona fa'atonuina i le Su'ega.

Fofo talafeagai fa'aoga: 0.05 mg/mL ta'itasi USP Carvedilol RS ma USP Carvedilol Related Compound C RS ile vaega feavea'i.

Fofo masani: 1 µg/mL ta'itasi USP Carvedilol RS, USP Carvedilol Related Compound A RS, USP Carvedilol Related Compound B RS, USP Carvedilol Related Compound D RS, ma USP Carvedilol Related Compound E RS, ma le 0.2 µg/mL USP Carvedilol Feso'ota'i Compound C RS i le vaega feavea'i

Fa'ata'ita'iga fofo: 1 mg/mL o Carvedilol ile vaega feavea'i

Faiga fa'akomepiuta

(Va'ai Chromatography <621>, Faiga Fa'atonu.)

Auala: LC

Su'esu'e: Lua galu umi, UV 220 ma 240 nm.Fa'aaoga le 220 nm mo le fa'atusatusaina o le carvedilol e feso'ota'i fa'atasi E, ma fa'aoga le 240 nm mo le carvedilol ma isi mea fa'apena uma.

Koluma: 4.6-mm × 15-cm;5-µm fa'apipi'i L7

Malosi o le koluma: 55℃

Fuafuaga tafe: 1 mL/min

Tele tui: 20 µL

Faiga talafeagai

Fa'ata'ita'iga: Fa'atonuga fa'aoga fofo

Mana'oga talafeagai

I'uga: NLT 17 i le va o le carvedilol ma le carvedilol e feso'ota'i fa'atasi C

Iloiloga

Faʻataʻitaʻiga: Fofo masani ma Faʻataʻitaʻiga fofo

Fa'atusatusa le pasene o le carvedilol related compound A, carvedilol related compound B, carvedilol related compound C, carvedilol related compound D, carvedilol related compound E, ma so'o se isi lava mea leaga ile vaega ole Carvedilol na ave:

I'uga = (rU/rS) × (CS/CU) × 100

rU	=	tali pito i luga ole pa'u feso'ota'i tutusa po'o so'o se isi mea le mama mai le Sample solution
rS	=	tali pito i luga ole pa'u feso'ota'i tutusa mai le vaifofo Tulaga.Ina ia faʻatusatusa le pasene o soʻo se isi lava le mama faʻaaoga le tali maualuga o le carvedilol.
CS	=	fa'atonuga o le fa'aputuga fa'atatau i le vaifofo Tulaga (mg/mL).Ina ia fuafua le pasene o soʻo se isi mea leaga mo CS, faʻaaoga le faʻaogaina o le USP Carvedilol RS.
CU	=	fa'atonuga o le Carvedilol i le fa'ata'ita'iga fofo (mg/mL)

Ta'iala e talia: Va'ai le Laulau 1.

Laulau 1

Igoa	Taimi Fa'amaufa'atasiga	Ta'iala Talia, NMT (%)
Carvedilol feso'ota'iga fa'atasi Ea	0.35	0.1
Carvedilol fesoʻotaʻiga faʻapipiʻi Ab	0.52	0.1
Carvedilol bisalkylpyrocatechol e maua mai (pe a iai)c	0.70	0.15
Carvedilol	1.0	—
Carvedilol feso'ota'i fa'atasi Cd	3.6	0.02
Carvedilol feso'ota'i fa'atasi De	5.0	0.1
Carvedilol feso'ota'i fa'atasi Bf	8.5	0.1
So'o se isi lava le mama	-	0.10
Aofa'i le mama	-	0.5g
a 2-(2-Methoxyphenoxy)ethyl amine. b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol). d 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. e 4-(Oxiran-2-ylmethoxy)-9H-carbazole. f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g Fa'aleaogaina so'o se mea leaga e itiiti ifo i le 0.01%.

• Oona Fa'aleaga, Fa'agasologa 2

Fofo A: Acetonitrile ma trifluoroacetic acid (100:0.1)

Fofo B: Trifluoroacetic acid ma vai (0.1:100)

Suavai: Acetonitrile, trifluoroacetic acid, ma vai (22:0.1:78)

Vaega feavea'i: Va'ai le Laulau 2

Laulau 2

Taimi (min)	Fofo A (%)	Fofo B (%)
0	22	78
20	22	78
33	38	62
45	38	62
55	55	45
65	55	45
68	22	78
80	22	78

Fofo talafeagai o le faiga: 1.0 mg/mL o le USP Carvedilol System Suitability Mixture RS i le Diluent

Fa'ata'ita'iga fofo: 1 mg/mL o le Carvedilol i le Diluent

Faiga fa'akomepiuta

(Va'ai Chromatography <621>, Faiga Fa'atonu.)

Auala: LC

Su'esu'e: UV 240 nm

Koluma: 4.6-mm x 15-cm;5-µm fa'apipi'i L68

Malosi o le koluma: 30℃

Ole fua ole tafe: 1.4 mL/min

Tele tui: 20 µL

Faiga talafeagai

Fa'ata'ita'iga: Fa'atonuga fa'aoga fofo

Mana'oga talafeagai

I'uga: NLT 1.8 i le va o le carvedilol ma le carvedilol e feso'ota'i fa'atasi F

Iloiloga

Fa'ata'ita'iga: Fa'ata'ita'iga fofo

Fa'atatau le pasene o mea leaga ta'itasi ile vaega ole Carvedilol na ave:

I'uga = (rU/rT) × 100

rU	=	tali pito i luga mo le le mama taʻitasi i le faʻataʻitaʻiga fofo
rT	=	le aofa'i o tali pito i luga uma i le Sample solution

Ta'iala e talia: Va'ai le Laulau 3.

Laulau 3

Igoa	Aiga Taofi Taimi	Taliaina Fa'atonuga, NMT (%)
Carvedilol fesoʻotaʻiga faʻapipiʻi Aa	0.7	0.1
Carvedilol	1.0	—
Carvedilol fesoʻotaʻiga faʻapipiʻi Fb	1.2	0.1c
N-Isopropylcarvedilold	1.6	0.1
Carvedilol feso'ota'i fa'atasi Ce	1.8	0.02
Carvedilol feso'ota'i fa'atasi Bf	2.1	0.1
Biscarbazoleg	3	0.1
So'o se isi lava le mama	—	0.1
Aofa'i le mama	—	0.5
a 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2-ol . b 1-(2-(2-Methoxyphenoxy)ethylamino)-3-(6,7,8,9-tetrahydro-5H-carbazol-4-yloxy) propan-2-ol. c O lenei le mama e fa'atatauina i le fa'aaogaina o le fa'agasologa i lalo ole Organic Impurities, Faiga 3: Carvedilol Related Compound F. d 1-(H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]N-isopropylamino]-2-propanol. e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g 1,3-Bis-(9H-carbazol-4-yloxy)-2-propanol.

• Oona Fa'aleaga, Fa'agasologa 3: Carvedilol Fa'atatau F (pe a iai)

Fofo A: Trifluoroacetic acid ma vai (0.5:100)

Fofo B: Methanol ma trifluoroacetic acid (100:0.5)

Suavai: Vai ma acetonitrile (1: 1)

Vaega feavea'i: Fofo A ma Fofo B (65:35)

Fofo talafeagai o le faiga: 1.5 mg/mL o le USP Carvedilol System Suitability Mixture RS i le Diluent

Fa'ata'ita'iga vaifofo: 1.5 mg/mL o le Carvedilol ile Diluent saunia fa'apenei.Fa'aaoga pe tusa ma le 1.9 mL o le Diluent i le mg o le Carvedilol, ma sonika fa'apuupuu e faafaigofie ai le fa'amavaeina.

Faiga fa'akomepiuta

(Va'ai Chromatography <621>, Faiga Fa'atonu.)

Auala: LC

Su'esu'e: UV 226 nm

Koluma: 4.6-mm × 30-mm;3-µm fa'apipi'i L7

Koluma vevela: 40℃

Fuafuaga tafe: 2 mL/min

Tele tui: 10 µL

Faiga talafeagai

Fa'ata'ita'iga: Fa'atonuga fa'aoga fofo

Mana'oga talafeagai

I'uga: NLT 2.0 i le va o le carvedilol ma le carvedilol e feso'ota'i fa'atasi F

Iloiloga

Fa'ata'ita'iga: Fa'ata'ita'iga fofo

Fa'atatau le pasene ole fa'ameamea fa'atatau ile carvedilol F ile vaega ole fa'ata'ita'iga na ave:

I'uga = (rU/rT) × (1/F) × 100

rU	=	tali pito i luga ole carvedilol feso'ota'i fa'afefiloi F mai le fa'ata'ita'iga fofo
rT	=	aofa'iga o tali pito i luga ole carvedilol ma carvedilol feso'ota'iga fa'aputu F mai le fa'ata'ita'iga fofo
F	=	fa'atatau tali tali, 1.1

Ta'iala e talia: NMT 0.1%

SU'E FA'AMANATU

• Ma'imau ile Fa'amago <731>: Fa'amago se fa'ata'ita'iga ile 105℃ mo le 3 itula: e to'esea le NMT 0.5% o lona mamafa.

FAAOPOOPOGA

• Fa'apipi'i ma Teuina: Fa'asa'o i totonu o atigipusa fufusi, ma teu i le vevela o le potu.

• Fa'ailoga: Afai e fa'aogaina se su'ega mo Organic Impurities e le HPLC e ese mai i le Fa'agasologa 1, ona fa'ailoa mai lea e le fa'ailoga le su'ega o lo'o tausisia e le tala.

• USP Reference Standards <11>

USP Carvedilol RS

USP Carvedilol Related Compound A RS
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2- ol.
C36H43N3O7 629.74

USP Carvedilol Related Compound B RS
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74

USP Carvedilol Related Compound C RS
1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
C31H32N2O4 496.60

USP Carvedilol Related Compound D RS
4-(Oxiran-2-ylmethoxy)-9H-carbazole.
C15H13NO2 239.27

USP Carvedilol Related Compound E RS
2-(2-Methoxyphenoxy)ethyl amine.
C9H13NO2 167.21

USP Carvedilol System Suitability Mixture RS
Fa'afefiloi e tusa ma le 0.1% carvedilol feso'ota'i fa'atasi F (1-(2-(2-Methoxyphenoxy)ethylamino)-3-(2,3,4,9-tetrahydro-1H-carbazol-5-yloxy)propan-2-ol) i totonu o se matrix o vailaʻau vailaʻau carvedilol.