Risperidone CAS 106266-06-2 Su'ega 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Risperidone (CAS: 106266-06-2) faʻatasi ai ma tulaga maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Risperidone,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Risperidone |
| Synonyms | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a] pyrimidin-4-tasi;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 106266-06-2 |
| Fuafua mole | C23H27FN4O2 |
| Molecular Weight | 410.49 g/mol |
| Lisi Lisi | 170.0 i le 174.0 ℃ |
| Malosi | 1.38±0.10g/cm3 |
| Vasega o Tulaga Lamatia | 6.1;Oona |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga | I'uga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e | E usitaia |
| Faailoaina A | Infrared Absorption | E usitaia |
| Faailoaga B | Taimi Taofi: E fetaui ma Mea Fa'asino | E usitaia |
| Ma'imau ile Fa'amago | <0.50% | 0.12% |
| Toega i luga o le mumu | <0.10% | 0.07% |
| Metala mamafa | <0.001% | <0.001% |
| Fa'atasiga Fa'atasi | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| So'o se Fa'aleaga Le Malamalama | <0.10% | <0.10% |
| Aofa'i Fa'aleaga | <0.30% | <0.30% |
| Su'ega | 98.0~102.0% (Fa'atatau ile Fa'amamago) | 100.52% |
| Fa'ai'uga | Ua uma ona fa'ata'ita'i le oloa ma fa'amalieina le USP 35 Standard | |
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Risperidone
C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-tasi, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a] pyrimidin-4-tasi [106266-06-2].
» Risperidone e le itiiti ifo i le 98.0 pasene ae le sili atu i le 102.0 pasene ole C23H27FN4O2, fuafua ile fa'amago.
Fa'apipi'i ma teuina- Fa'asao i pusa tapuni lelei.Teu i le vevela o le potu.
USP Reference standards <11>-
USP Risperidone RS
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-tasi 410.48 CAS-106266-06-2
USP Risperidone System Suitability Mixture RS
O lo'o iai risperidone ma e tusa ma le 0.2% o mea ta'itasi nei:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-tasi.
9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-tasi.
6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-tasi.
[Manatua-O lenei paluga e aofia ai risperidone, Z-oxime, 9-hydroxyrisperidone, ma le 6-methylrisperidone.]
Fa'ailoa-
A: Infrared absorption <197K>.
B: O le taimi fa'atumauina o le tumutumu tele i le chromatogram o le sauniuniga Su'esu'e e fetaui ma lena i le chromatogram o le sauniuniga Tulaga, e pei ona maua i le Su'ega.
Ma'imau ile fa'amago <731>- Fa'amamago ile vacuum ile 80 mo le 4 itula: e le sili atu ile 0.5% o lona mamafa.
Toega i luga o le afi <281>: e le sili atu i le 0.1%, o loʻo faʻaaogaina se faʻataʻitaʻiga 2.0-g.
Metala mamafa, Metotia II <231>: 0.001%.
Fa'atasiga fa'atasi-
Fofo faʻapipiʻi, Fofo A, Fofo B, Vaega feaveaʻi, Diluent, Fofo talafeagai faʻaoga, ma le Chromatographic system-Sauni e pei ona faʻatonuina i le Suʻega.
Fofo masani-Faʻaaoga le sauniuniga Faʻatonu, saunia e pei ona faʻatonuina i le Suʻega.
Su'ega fofo-Fa'aoga le sauniuniga Su'ega.
Fa'atonu-Tu'i voluma tutusa (e tusa ma le 10 µL) o le vaifofo Fa'ata'atia ma le vaifofo o le Su'ega i totonu o le chromatograph, ma fa'amaumau le chromatogram.Fa'ailoa mea le mama e fa'aaoga ai taimi fa'amautu fa'atatau o lo'o tu'uina atu i le Siata 1, ma fuaina tali pito i luga.Fa'atatau le pasene o vaega ta'itasi e feso'ota'i risperidone i le vaega ole Risperidone e ave ile fua fa'atatau:
100(CS /CU)(rU / rS)(1/F)
lea o le CS ma le CU o loʻo i ai faʻatonuga, i mg i le mL, o le risperidone i le vaifofo masani ma le suʻega suʻega taʻitasi;rU o le vaega pito i luga ole eleelea taitasi e maua mai le vaifofo o le Su'ega;rS o le vaega pito i luga ole risperidone e maua mai le vaifofo Tulaga;ma F o le tali fa'atatau mo mea leaga ta'itasi e fa'atatau i le risperidone.I le faaopoopo atu i le le sili atu i tapulaʻa i le Laulau 1, e le sili atu i le 0.10% o soʻo se mea le mama e le iloa (faʻaaoga le tau F o le 1.0) e maua ma e le sili atu i le 0.30% o le aofaʻi o mea leaga e maua.Fa'aleaogaina tumutumu le mama e la'ititi ifo i le 0.05%.
Laulau 1
Taimi Fa'atumauina Fa'atatau Fa'atasi (RRT) Fa'atatau Tali (F) Tapulaa (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido [1,2-a] pyrimidin-4-tasi
2 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido [1,2-a] pyrimidin-4-tasi
3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-tasi
4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-tasi
5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-tasi
Su'ega-
Fofo pa'u- Fa'amuta 15.4 g o le ammonium acetate i le 1 L o le vai.Fetuuna'i ma le 10% acetic acid i le pH o le 6.5, ma fa'afefiloi.
Fofo A-Faafefiloi le 100 mL o le vaifofo Pa'u ma le 150 mL o le methanol i totonu o se fagu volumetric 1000-mL, ma fa'afefe i le vai i le voluma.
Fofo B- Faafefiloi le 100 mL o le vaifofo Pa'u ma le 850 mL o le methanol i totonu o se fagu volumetric 1000-mL, ma fa'afefiloi i le vai i le voluma.
Vaega fe'avea'i-Fa'aaogā fa'afefiloi fesuisuia'i o Fofo A ma Fofo B e pei ona fa'atonuina mo le faiga o le Chromatographic.Faia ni fetuunaiga pe a talafeagai (tagai System Suitability i lalo ole Chromatography 621).
Diluent-Faafefiloi le 100 mL o le vaifofo Pa'u ma le 900 mL o le vai ma le 1000 mL o le methanol.
Fofo talafeagai faiga-Sauni se vaifofo 1 mg i le mL ole USP Risperidone System Suitability Mixture RS ile Diluent.
Sauniuniga masani-Fa'amuta se aofa'i sa'o le fuaina o le USP Risperidone RS i le Diluent, ma fa'afefiloi fa'atatau, ma fa'asolosolo fa'asolosolo pe a mana'omia, fa'atasi ma le Diluent e maua ai se vaifofo o lo'o i ai se fa'atonuga iloa e tusa ma le 1.0 mg i le mL.
Sauniuniga su'esu'e-Fa'amuta se aofa'i sa'o fua o le Risperidone i le Diluent, ma fa'afefiloi fa'atatau, ma fa'asolosolo fa'asolosolo pe a mana'omia, fa'atasi ai ma le Diluent e maua ai se vaifofo o lo'o i ai se fa'atonuga o le 1.0 mg i le mL.
Chromatographic system (silasila Chromatography <621>)- O le chromatograph vai ua fa'apipi'iina i le 275-nm detector ma le 4.6-mm × 10-cm koluma e iai le 3-µm fa'apipi'i L1.Ole fua ole tafe e tusa ma le 1.5 mL ile minute.O le vevela o le koluma e faʻatumauina i le 35. O le chromatograph ua faʻapipiʻiina e pei ona taua i lalo.
Taimi (minute) Fofo A (%) Fofo B (%) Elution
0–1 70 30 fa'aisocratic
1–20 70®5 30®95 gradient laina
20–25 5 95 fa'aisocratic
25–27 5®70 95®30 gradient laina
27–35 70 30 toe fa'atutusa Tu'i le vaifofo talafeagai o le System.Fa'amaumau tali pito i luga e pei ona fa'atonuina mo le Fa'atonuga, ma fa'ailoa pito i luga ona o le Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, ma le risperidone e fa'aaoga ai taimi fa'amauina (RRT) mai le Laulau 1;o le iugafono, R, i le va o le Z-oxime ma le 9-hydroxyrisperidone e le itiiti ifo i le 2.8;o le fa'ailoga mo le risperidone e le sili atu i le 1.5;ma o le eseesega o tulaga masani mo tui toe faia e le sili atu i le 2.0% mo le maualuga o le risperidone.
Fa'asologa- Tu'i ese voluma tutusa (tusa ma le 10 µL) o le sauniuniga Fa'ata'atia ma le Su'ega Su'ega i totonu o le chromatograph, ma fua tali mo le maualuga o le risperidone.Fa'atatau le aofa'i, ile pasene ole C23H27FN4O2, ile vaega ole Risperidone e ave ile fua fa'atatau:
100(CS /CU)(rU / rS)
lea o le CS ma le CU o loʻo i ai faʻatonuga, i le mg i le mL, o le risperidone i le sauniuniga Tulaga masani ma le sauniuniga Suʻega, i le faasologa;ma le rU ma le rS o tali maualuga ia e maua mai le sauniuniga Su'ega ma le sauniuniga Tulaga, i le faasologa.
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Tulaga lamatia R25 - Oona pe a foloina
R23/24/25 - Oona pe a manava, fa'afeso'ota'i ma pa'u ma pe a foloina.
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Fa'amatalaga Saogalemu S28 - A uma ona fa'afeso'ota'i ma le pa'u, fufulu vave i le tele o fasimoli.
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UN IDs 3249
WGK Siamani 3
RTECS UV1164800
HS Code 2934999099
Vasega o Tulaga Lamatia 6.1(a)
Vaega fa'apipi'i II
Risperidone (CAS: 106266-06-2) o loʻo i ai le faʻalavelave faʻafefe i luga o le 5HT2 receptors ma D2 receptors.Risperidone e faʻaaogaina mo le schizophrenia ogaoga ma le tumau.Vailaau fa'ama'i.Risperidone e faʻaaogaina mo le togafitia o le schizophrenia maʻi ma le tumau ma isi tulaga faʻapitoa o le mafaufau e iloagofie ai faʻamaoniga lelei (e pei o le mafaufau, faʻasesega, faʻalavelave mafaufau, ita, masalosaloga) ma faʻaʻailoga le lelei (e pei o le le tali atu, lagona le fiafia ma le le fiafia, o nai tagata toʻaitiiti. upu).E mafai fo'i ona fa'aitiitia fa'ailoga fa'aleagaina e feso'ota'i ma le schizophrenia (e pei o le: fa'anoanoa, tausalaina, popolevale).Mo tagata mama'i o lo'o aoga le Risperidone mo togafitiga ogaoga, i le vaega o le tausiga o togafitiga, e mafai e le Risperidone ona fa'aauau pea ona ta'alo lona aoga.O le mea lea, o le Risperidone, o lo'o i ai se gaioiga fa'afoma'i i fa'ailoga lelei ma le le lelei o le schizophrenia ma fa'atupu ai le fa'aitiitia o a'afiaga aemaise fa'ailoga extrapyramidal pe a fa'atusatusa i vaila'au fa'afeagai D2 mama e masani ona fa'aaogaina.O lo'o iai fo'i le avanoa e pulea ai le fa'amuta o le 'ava mālosi ma vaisu o cocaine.
