4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid CAS 123654-26-2 Prucalopride Succinate Intermediate Mama ≥98.0% (HPLC)
Shanghai Ruifu Chemical o le taʻutaʻua taʻutaʻua o le 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2) ma le maualuga maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Prucalopride Succinate Intermediates,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid |
| Synonyms | 4-Amino-5-Chlorocoumaran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydrobenzo[b]furan-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid;Prucalopride Le mama A;Prucalopride Succinate Le mama-2 |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 123654-26-2 |
| Fuafua mole | C9H8ClNO3 |
| Molecular Weight | 213.62 g/mol |
| Lisi Lisi | 242℃(Tes.) |
| Fa'apuna | 406.5±45.0℃ |
| Malosi | 1.566 |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Vaega | Intermediate of Prucalopride Succinate (CAS: 179474-85-2) |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Pa'e-Pa'epa'e i le Malamalama-Mula | Malosi-Mula-Mula |
| Vai saunia e Karl Fischer | ≤1.00% | 0.35% |
| Toega i luga o le mumu | <0.20% | 0.08% |
| Metala mamafa (Pb) | ≤20ppm | <10ppm |
| Le mama nofofua | ≤1.00% | E usitaia |
| Aofa'i Fa'aleaga | ≤2.00% | E usitaia |
| Mama / Suʻesuʻega Metotia | ≥98.0% (HPLC) | 99.6% |
| Alaleo Infrared | E tusa ma le Fauga | E usitaia |
| 1 H NMR Alaleo | E tusa ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Taofi mau le atigipusa ma teu i totonu o se faleteuoloa malulu, mago (2~8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.
O lenei oloa o le 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid, o le anotusi o le C12H12ClNO4 e le tatau ona itiiti ifo i le 98.0%, fuafua i luga o le anhydrous faavae.
[Properties] O lenei oloa e pa'epa'e e o'o atu i le mumu-mumu mumu.
[Siaki]
Ave se aofaiga talafeagai o lenei oloa (e tusa ma le 0.5g) o le vai, faʻaopopo le solvent (methanol: N, N-dimethylformamide = 50:50), ma faʻamavae e tusa ai ma le auala e fuafua ai le vai (Faʻaopoopoga Ⅷ M, auala muamua A).Fa'aaoga su'ega a Fisher e fa'amautu ai se'ia sui le vaifofo mai le samasama mumu i le mūmū-enaena e fa'ailoa ai le fa'ai'uga, ma fai se isi su'ega avanoa.Fa'atatau e tusa ai ma le fua fa'atatau: o le vai e le tatau ona sili atu i le 1.00%.
Susū (%) = (AB) F/W×100%
Pe a, A o le voluma lea o le vai a Fisher na fa'aaogaina e le oloa su'esu'e (ml);
B o le voluma ole sua su'e a Fisher na fa'aaogaina ile avanoa avanoa, ml;
F o le mamafa ole su'ega fofo a Fisher e tutusa ma le vai ile 1ml, mg;
W o le mamafa o le su'ega oloa, mg
Mea fa'atatau
E tusa ai ma le metotia i lalo o le "mea e fuaina ai mea", afai o loʻo i ai ni faʻamaʻi eleelea i le chromatogram o le suʻega vaifofo, o le pito i luga o se tasi le mama e le tatau ona sili atu nai lo le 10 taimi (1.0%) o le vaega pito i luga o le pule. fofo, ma o le aofaʻi o le pito i luga o mea leaga uma e le tatau ona sili atu nai lo le 20 taimi (2.0%) o le vaega pito i luga o le vaifofo pulea.
[Igoa Fuafuaga] E tusa ai ma le maualuga o le faatinoga o le chromatography vai (Faaopoopoga VI D).
O le Octadecylsilane bonded silica gel na faʻaaogaina e fai ma faʻatumu mo tulaga chromatographic ma suʻega talafeagai.Fofo fa'afefete fa'afefete (1.36g potassium dihydrogen phosphate, fa'amavae ultrasonic i le vai 1L, phosphoric acid ua fa'afetaui i le PH 3.0) na fa'aaogaina e pei o le vaega feavea'i A. Acetonitrile o le vaega feavea'i B, ma e fa'atino le gradient elution e tusa ai ma le laulau lenei:
Taimi (min) Vaega feavea'i A vaega feavea'i B
0 80 20
15 80 20
30 50 50
45 50 50
Ole umi ole galu ole iloa ole 254 nm.Ole fua ole tafe ole 1.0 ml/min.Ole numera o papatusi faʻapitoa e le itiiti ifo i le 2000 e tusa ai ma le maualuga ole 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid
Ole maualuga ole furanoformic acid e le itiiti ifo ile 2000.
Metotia o filifiliga:
Ave le 10mg o le suʻega oloa, fua saʻo, tuʻu i totonu o se fagu 10ml, faʻamaʻapeina le ultrasonic ma le vaega feaveaʻi A-mobile phase B (70:30) e pei o le solvent, faʻafefe i le fua, lulu lelei, ma saunia se fofo ma se faʻatonuga o le 1mg/ml.20 l o le sa'o na tui i totonu o le chromatograph vai, ma fa'amaumau le chromatogram.O le mama pito i luga e le itiiti ifo i le 98.0% e tusa ai ma le auala masani masani
Koluma: Dionex Acclaim C18, 4.6*250mm, 5um
Koluma vevela: 40℃
Fuafuaga tafe: 1.0ml / min
Sailiga umi galu: 254nm
Fa'ata'ita'iga tele: 10μL
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2), e mafai ona faʻaaogaina e fai ma mea faʻapitoa mo le faʻaogaina o le Prucalopride Succinate (CAS: 179474-85-2), o se 5-HT4 receptor agonist filifilia e faʻaaogaina lelei mo le faʻamaʻi tumau.Prucalopride Succinate, o se dihydrobenzofurancarboxamide muamua-i-vasega, o se serotonin filifilia (5-HT4) agonist talisuaga.O le vailaʻau, faʻatau atu i lalo o le igoa Resolor®, o loʻo i ai le enterokinetic activity ma na atiaʻe e le Belgian-based pharmaceutical firm Movetis.O le Prucalopride e suia le faʻaogaina o le colonic motility e ala i le serotonin 5-HT4 faʻaosofia le tali, faʻaosoina le malosi faʻamalosi mo le faʻafefe.
