Gefitinib Intermediate CAS 199327-61-2 Mama>99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o le 7-Methoxy-6-(3-Morpholin-4-ylpropoxy) quinazolin-4 (3H) -One (CAS: 199327-61-2) faʻatasi ai ma tulaga maualuga, vaeluagalemu. o Gefitinib (CAS: 184475-35-2).Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Gefitinib Intermediates,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | 7-Methoxy-6-(3-Morpholin-4-ylpropoxy)quinazolin-4(3H)-Tasi |
| Synonyms | 7-Methoxy-6-(3-Morpholinopropoxy)quinazolin-4(3H)-Tasi;7-Methoxy-6-[3-(4-Morpholinyl)propoxy]-4(3H)-Quinazolinone;7-Methoxy-6-(3-Morpholinopropoxy)quinazolin-4-One |
| le mama | Gefitinib le mama 5;Gefitinib EP Le mamā A |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 199327-61-2 |
| Fuafua mole | C16H21N3O4 |
| Molecular Weight | 319.36 g/mol |
| Lisi Lisi | 242.0~247.0 ℃ |
| Malosi | 1.32±0.10g/cm3 |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e | E usitaia |
| Lisi Lisi | 242.0~247.0 ℃ | 243.6~244.5 ℃ |
| Ma'imau ile Fa'amago | <0.50% | 0.15% |
| Toega i luga o le mumu | <0.20% | 0.11% |
| Le mama nofofua | <0.50% | <0.30% |
| Aofa'i Fa'aleaga | <1.00% | 0.30% |
| Mama / Suʻesuʻega Metotia | >99.0% (HPLC) | 99.7% |
| 1H NMR Alaleo | O gatasi ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
| Fa'atatauga | Intermediate of Gefitinib (CAS: 184475-35-2) | |
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7-Methoxy-6-(3-Morpholin-4-ylpropoxy)quinazolin-4(3H)-One (CAS: 199327-61-2) o se mea vavalo / le mama o Gefitinib (CAS: 184475-35-2).O le Gefitinib o se vailaʻau faʻapitoa faʻapitoa e faʻatatau i le tumor na atiaʻe e AstraZeneca, UK.O le Gefitinib o le vailaʻau muamua mole mole mole mo le togafitia o le kanesa o le mama e le o ni sela laiti.E galue e ala i le filifili fa'alavelaveina le ala fa'aliliuina fa'ailoga o le epidermal growth factor receptor tyrosine kinase (EGFR-TK).I le masina o Aukuso 2002, na muai maketiina ai Gefitinib i Iapani e avea o se togafitiga muamua mo le kanesa o le mama sela laiti i lalo o le igoa tau fefaatauaiga Iressa.I le masina o Me 2003, na fa'amaonia ai e le US Food and Drug Administration le Gefitinib e avea ma monotherapy laina lona tolu mo tagata mama'i o lo'o maua i le kanesa o le mama mama e le'i la'ititi e le'i aoga i vaila'au fa'ama'i fa'ama'i ma le docetaxel chemotherapy.I le taimi nei, Gefitinib ua faʻamaonia e Ausetalia, Iapani, Atenitina, Sigapoa ma Korea i Saute mo le togafitiga o le kanesa o le mama mama e le o ni mea laiti.I le aso 28 o Fepuari, 2005, na faʻamaonia ai e le China Food and Drug Administration le Gefitinib mo le togafitia o le kanesa o le mama i le lotoifale poʻo le metastatic non-small cell lung cancer (NSCLC) lea na maua muamua le chemotherapy.E le'o fa'atagaina i le taimi nei mo le fa'aaogaina e fai ma togafitiga muamua mo NSCLC maualuga.I le aso 1 o Iulai, 2009, na fa'amaonia aloaia ai e le European Medicines Agency le Gefitinib mo le laina muamua, laina lona lua ma le laina lona tolu o togafitiga o le kanesa o le mama i le lotoifale po'o le metastatic e le o ni tama'i sela mama fa'atasi ai ma suiga o gene EGFR i tagata matutua.
