3-Chloro-4-(3-Fluorobenzyloxy)aniline CAS 202197-26-0 Lapatinib Amioga Mamao >98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o le 3-Chloro-4-(3-Fluorobenzyloxy) aniline (CAS: 202197-26-0) faʻatasi ai ma le maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Lapatinib Intermediates,Please contact: alvin@ruifuchem.com
Igoa Vailaau | 3-Chloro-4-(3-Fluorobenzyloxy)aniline |
Synonyms | 3-Chloro-4-[(3-Fluorophenyl)methoxy]aniline;4-(3-Fluorobenzyloxy)-3-Chlorobenzenamine;Lapatinib Intermediate B |
Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
Numera CAS | 202197-26-0 |
Fuafua mole | C13H11ClFNO |
Molecular Weight | 251.69 g/mol |
Lisi Lisi | 78.0 i le 82.0 ℃ |
Malosi | 1.306±0.06 g/cm3 |
COA & MSDS | Avanoa |
Fa'ata'ita'iga | Avanoa |
Amataga | Shanghai, Saina |
Fa'ailoga | Ruifu Chemical |
Aitema | Tulaga Fa'atonu | I'uga |
Fa'aaliga | Enaena enaena i le Pata uliuli | E usitaia |
Lisi Lisi | 78.0 i le 82.0 ℃ | 80.7 ℃ |
Ma'imau ile Fa'amago | <1.00% | E usitaia |
Toega i luga o le mumu | <0.50% | E usitaia |
Fa'aleaga Fa'atatau e le HPLC | <2.00% | 0.64% |
Mama / Suʻesuʻega Metotia | >98.0% (HPLC) | 99.36% |
1H NMR Alaleo | O gatasi ma le Fauga | E usitaia |
Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
Fa'atatauga | Intermediate o Lapatinib / Lapatinib Ditosylate Monohydrate |
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Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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UN IDs 3077
HS Code 2921420090
Vasega o lamatiaga 9
Vaega fa'aputu III
3-Chloro-4-(3-Fluorobenzyloxy)aniline (CAS: 202197-26-0) o se vaeluagalemu i le tuufaatasia o Lapatinib / Lapatinib Ditosylate Monohydrate.
Lapatinib o se vailaʻau faʻatatau i le kanesa o le susu na atiaʻe e le British GlaxoSmithKline Co. Human ErbB receptors e aofia i le ituaiga I tyrosine kinase (TK) receptor aiga, e aofia ai ErbB1 (EGFR), ErbB2 (HER2), ErbB3 (HER3), ma ErbB4 (HER4) .Ole ErbB-1 (EGFR) ma le ErbB-2 (HER-2) e masani ona faʻaalia pe suia i tagata mamaʻi kanesa.Tagata epidermal growth factor receptor 2 (ErbB-2, HER-2) ua iloa o se tagata oncogene e vavalalata vavalalata ma le kanesa o le susu.O lona fa'aaliga maualuga i le kanesa o le susu e masani ona va'ai ai le metastasis o le lymph node ma le le lelei o le tumo, ma le le lelei o le fa'asologa.O le HER-2 o se tasi o mole mole mole mole mo le kanesa o le susu.Lapatinib e mafai ona galue i le taimi e tasi i Her-1 Her-2.O a'afiaga fa'aola o lenei metotia e taofia ai le fa'atuputeleina ma le tuputupu a'e o sela tumo e sili atu le tele nai lo le na'o le galue i luga o le tasi sini.O le tuʻufaʻatasiga o Lapatinib ma Capecitabine e faʻaaogaina e togafitia ai tagata mamaʻi e maua i le kanesa o le susu maualuga poʻo metastatic ma le faʻaalia o le epidermal receptor2 tagata, ua uma ona togafitia i anthracyclines, paclitaxel, ma trastuzumab.O su'esu'ega fa'afoma'i ua fa'aalia ai o Lapatinib e togafitia lelei fo'i ma'i kanesa ituaiga HER2 ma le Herceptin resistance.