Vardenafil Intermediate CAS 224789-21-3 Mama> 99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o le 2-(2-Ethoxyphenyl) -5-Methyl-7-Propylimidazo [5,1-F][1,2,4] triazin-4(3H) -one (CAS: 224789-21-3) faʻatasi ai ma tulaga maualuga, vaeluaga o Vardenafil.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Vardenafil Intermediates,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-tasi |
| Synonyms | Vardenafil Dessulfonyl Le mama;2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazo[5,1-F][1,2,4]triazin-4-tasi;Vardenafil Propyl Imidazotriazinone Le mama;Vardenafil Related Compound 1 |
| Tulaga Fa'asoa | I Fa'atauga, Gaosi Gaosi 2 Tone i le Masina |
| Numera CAS | 224789-21-3 |
| Fuafua mole | C17H20N4O2 |
| Molecular Weight | 312.37 g/mol |
| Lisi Lisi | 142.0~148.0 ℃ |
| Malosi | 1.26±0.10g/cm3 |
| Teuga umi | Nofoaga malulu ma mago (2~8℃) |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga | I'uga |
| Fa'aaliga | Pa'epa'e-Pa'epa'e i le Pa'u Samasama Samasama | Pa'u Pa'epa'e Pa'epa'e |
| Lisi Lisi | 142.0~148.0 ℃ | 146.0~147.0 ℃ |
| Ma'imau ile Fa'amago | <1.00% (102℃, 3h) | 0.23% |
| Metala mamafa (Pb) | ≤20ppm | <20ppm |
| Mama / Suʻesuʻega Metotia | >99.0% (HPLC) | 99.79% |
| 1H NMR Alaleo | O gatasi ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
| Fa'atatauga | Intermediate o Vardenafil / Vardenafil Hydrochloride | |
afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Taofi mau le atigipusa ma teu i totonu o se faleteuoloa malulu, mago (2~8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le la ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.
1. Fa'aaliga: Tu'u le fa'ata'ita'iga i luga o le pepa pa'epa'e ma mata'ituina foliga vaaia, pa'epa'e pa'epa'e i le pa'epa'e samasama.
2. Iloiloga:
2.1 Su'esu'ega Fa'alili e tusa ai ma le tulafono (Fa'ama'i Fa'aSaina 2010 Lomiga II Fa'aopoopo ⅥC) Ole liusuavai ole 142.0~148.0℃.
2.2 Ma'imau ile Fa'amago: Fa'ai'uga e tusa ai ma le tulafono (Fa'aopoopo ⅧL, Vaega II, Lomiga 2010 a le Chinese Pharmacopoeia).Fuafuaga sa'o le aofa'i talafeagai o lenei oloa, mago i le 102 ℃ mo le 3 itula, pa'u mamafa e le tatau ona sili atu i le 1.00%.
2.3 Uamea Mamafa: Fa'aiuga e tusa ai ma le tulafono (People's Republic of China Pharmacopoeia 2010 Edition, Vaega II Fa'aopoopo ⅧH) Fa'ai'uga e ala i le auala lona lua.
Fuafua saʻo 1.0g o le oloa suʻega, mu lemu seia atoatoa carbonized, malulu, faaopoopo 0.5-1.0ml sulfuric acid, fai ia susu, vevela i le vevela maualalo seia oo ina vaivai le sulfuric acid, faaopoopo 0.5ml nitric acid, ausa mago, seia o le ausa oxide nitrogen ua vaivai, malulu, vevela i le 500-600 ℃ e atoatoa carbonized, malulu, faaopoopo 2ml hydrochloric acid, A uma ona mago i totonu o se vai taele, faaopoopo le 15ml vai, faapa'u le vaifofo su'ega ammonia seia oo ina le faaituau i le faailoga phenolphthalein. fofo, faʻaopopo 2ml acetate paʻu (ph3.5), ma faʻafefete sina vevela, faʻanofo i le Nachner colorimetric tube, ma faʻafefe i le 25ml i le vai.Ave se isi reagent mo le saunia o le vaifofo suʻega, ma faʻafefe i totonu o se ipu porcelain, faʻaopopo le 2ml acetate buffer (PH3.5) ma le 15ml vai i sina vevela A maeʻa le faʻamavaeina, faʻanofo le Nath colorimetric tube, faʻaopoopo se aofaʻi o vaifofo masani masani, ona fa'asusu lea ile vai ile 25ml.Fa'ata'ita'iga colorimetric o lo'o fa'atinoina ile va ole su'ega fofo ma le vaifofo masani e maua.Fuafuaga fofo masani saunia e tusa ai ma (People's Republic of China Pharmacopoeia 2010 lomiga II Fa'aopoopo Ⅷ Metoda su'ega u'amea mamafa) le auala muamua.O u'amea mamafa e le tatau ona sili atu i le 20 vaega i le miliona.
3. Mama: E tusa ai ma le maualuga o le faatinoga o le chromatography vai, fuafuaina e tusa ai ma le tulafono (Chinese Pharmacopoeia 2010 lomiga II Appendix VD).
Tulaga Chromatographic:
Koluma: C18, 200mm×4.6mm, 5μm;
Vaega feavea'i: Fosphate pa'u (mafaufau 2.72g potassium dihydrogen phosphate, fa'aopopo vai e fa'amavae ma fa'afefe i le 1000ml, fetuunai pH=3.5): acetonitrile: = 35:65;
Sailiga umi galu: 254nm;
Fuafuaga tafe: 1.0ml / min.
Fuafuaga auala: Ave le tusa ma le 30mg o lenei oloa, fuaina saʻo, faʻafefe i le telefoni feaveaʻi e fai ai le faʻatonuga o le 0.3mg / ml, ave le 20μl i le chromatograph vai, faʻamaumau le chromatogram.E tusa ai ma auala masani o le eria, o le mama e le itiiti ifo i le 99.0%.
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Tausaga Aafiaga?E sili atu nai lo le 15 tausaga o le poto masani i le gaosiga ma le auina atu i fafo o le tele o tulaga maualuga o vailaʻau faʻapitoa poʻo vailaʻau lelei.
Maketi Autu?Faʻatau atu i maketi i totonu o le atunuʻu, Amerika i Matu, Europa, Initia, Korea, Iapani, Ausetalia, ma isi.
Tulaga lelei?Tulaga maualuga, tau taugofie, auaunaga faʻapolofesa ma lagolago faʻapitoa, vave tuʻuina atu.
Tulaga leleiFaamautinoaga?Fa'atonuga lelei faiga.O meafaigaluega faʻapitoa mo suʻesuʻega e aofia ai le NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Fa'ata'ita'iga?O le tele o oloa e maua ai faʻataʻitaʻiga e leai se totogi mo le iloiloga lelei, o tau o felauaiga e tatau ona totogi e tagata faʻatau.
Fale Su'etusi?Fa'afeiloa'i su'etusi falegaosimea.Fa'amolemole fai se taimi vave.
MOQ?Leai MOQ.Laititi oka e talia.
Taimi Tiliva? Afai o loʻo i totonu o faʻatauga, e tolu aso e faʻamaonia le tuʻuina atu.
Felauaiga?E ala ile Express (FedEx, DHL), ile Air, ile Sea.
Pepa?A maeʻa le faʻatau atu auaunaga: COA, MOA, ROS, MSDS, ma isi mea e mafai ona tuʻuina atu.
Tulaga Fa'apitoa?E mafai ona tu'uina atu au'aunaga tu'ufa'atasiga fa'apitoa e fetaui lelei ma au su'esu'ega mana'oga.
Tulaga Totogi?Proforma invoice o le a lafo muamua pe a maeʻa le faʻamaoniga o le poloaiga, faʻapipiʻi a matou faʻamatalaga faletupe.Totogi e le T / T (Telex Transfer), PayPal, Western Union, ma isi.
2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one (CAS: 224789-21-3) o se vaeluagalemu o Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).Vardenafil o se PDE5 inhibitor fou na faʻalauiloaina mo togafitiga tautala o le male erectile male ma e iai lona faʻatusa taua ma le sildenafil (Viagra), o le muamua PDE5 inhibitor na faʻalauiloaina i le 1998 mo lenei faʻamatalaga.
Vardenafil o le sui lona lua na faʻatauina ma maua le avanoa e le faʻaitiitia ai lona taimi amata e ala i le tagofia o vailaʻau i luga o le manava atoa.E 30 taimi sili atu le malosi o se inhibitor o le PDE5 (o lona uiga o le IC50, 3.9 nM) nai lo le sildenafil ma le 10 taimi sili atu le malosi nai lo le tadalafil, faʻatasi ai ma se filifiliga sili atu (> 1,000 taimi) mo PDE5 tagata nai lo PDE2, PDE3, ma PDE4 ma tagata. feololo le filifilia (>80 taimi) mo PDE1.Le PDE inhibitory selectivity ma le in vitro ma in vivo le malosi ole PDE5 inhibitor vardenafil fou.Vardenafil faʻapitoa faʻasaina le hydrolysis o le cGMP e PDE5, faʻatasi ai ma le IC50 o le 0.7 nM (sildenafil 6.6 nM).O le IC50 o vardenafil mo PDE1 o 180 nM, mo PDE6 11 nM, ma mo PDE2, PDE3 ma PDE4 sili atu i le 1,000 nM.
