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Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Mama ≥99.0% (HPLC)
O le Ruifu Chemical o le taʻitaʻia o le Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) faʻatasi ai ma le tulaga maualuga, vavalo o Apixaban (CAS: 503612-47-3).E mafai e Ruifu ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, laʻititi ma tele tele avanoa.Fa'atau Apixaban intermediates, I-meli: alvin@ruifuchem.com
| Igoa Vailaau | Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate |
| Synonyms | Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate;(Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene];Apixaban-2;Apixaban le mama 3 |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 27143-07-3 |
| Fuafua mole | C11H13ClN2O3 |
| Molecular Weight | 256.69 g/mol |
| Lisi Lisi | 94℃ |
| Malosi | 1.23 |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Vaega | Intermediate of Apixaban (CAS: 503612-47-3) |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Samasama moli i le Pata Samasama | E usitaia |
| Ma'imau ile Fa'amago | <0.50% | 0.23% |
| Mama / Suʻesuʻega Metotia | ≥99.0% (HPLC) | 99.3% |
| Alaleo Infrared | E tusa ma le Fauga | E usitaia |
| 1 H NMR Alaleo | O gatasi ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Taofi mau le atigipusa ma teu i totonu o se faleteuoloa malulu, mago (2~8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.
Lisi o Solvent Fa'aaogaina i Gaosi Mea
| Leai. | Igoa | CAS Nu. | Fuafua mole |
| 1 | Ethyl Acetate | CAS: 141-78-6 | C4H8O2 |
| 2 | Dichloromethane | CAS: 75-09-2 | CH2Cl2 |
| 3 | Ethyl Alcohol | CAS: 64-17-5 | C2H5OH |
5.3.1 Fa'aaliga: E tatau ona lanu samasama i le pauta samasama.Va'ai, tu'u ia lava le aofa'i o mea fa'ata'ita'i (e aunoa ma le mamafa) i totonu o se ipu tioata mama i luga o se papa'e pa'epa'e (pei o le pepa pa'epa'e) i lalo ole malamalama fa'anatura.
5.3.2 Fa'ailoaina: 1H-NMR e tutusa le fausaga ma le tulaga masani.10 ~ 15mg o le faʻataʻitaʻiga na fuaina i totonu o le faʻaputu maneta faaniukilia, ma 0.5mL o le deuterium DMSO na faʻaopoopoina e faʻamavae atoa ai le faʻataʻitaʻiga, ona faʻataʻitaʻiina lea i se mea faʻainisinia maneta resonance e sili atu i le 400MHz.
5.3.3 Ma'imau pe a fa'agogo : Fua le fa'ata'ita'iga e tusa ma le 1.0g ma fa'agogo mo le 3h i totonu o se ogaumu fa'amago i le 85℃.O le fa'atinoga fa'apitoa mo le fa'atatauina o le pa'u mamafa e tatau ona fa'atinoina e tusa ai ma aiaiga o le SOP-AP-QC-002-01 mo le Fa'amauina o le Fa'amamago o le Mamafa.
5.3.4.1 Tulaga Chromatographic:
Su'ega su'ega: 1) acetonitrile mo chromatography 2) vai mama 3) phosphoric acid
Koluma: WondaCract ODS-2 4.6*250mm*5um (8520-39993)
Vaega feavea'i: A: Fua sa'o le 1.0ml phosphoric acid ma le 1000ml vai, faamama ultrasonic degassing.
B: Acetonitrile.
Fa'agasologa fa'asolosolo: o le laulau lea
Taimi vaega feavea'i A (%) Vaega feavea'i B (%)
3 90 10
10 25 75
20 0 100
25 0 100
Su'esu'e: 210nm
Malosi o le koluma: 35℃
Saosaoa tafe: 1.0ml / min
Tele fa'ata'ita'iga: 5µl
5.3.4.2 Saunia o fofo:
5.3.4.3 Suavai: acetonitrile
5.3.4.4 Fofo gaogao: e tatau ona fa'aogaina le vai fa'afefiloi e fai ma vaifofo avanoa.
5.3.4.5 Su'ega vaifofo o oloa: Fua fua le oloa su'esu'e e tusa ma le 12.5mg i totonu o se fagu volumetric 25ml ma fa'amavae ma fa'afefiloi i le fua.
5.3.4.6 Faiga fa'agaioiga: A mae'a ona mautu le laina fa'avae o le meafaigaluega, tasi i le lua tui o le vaifofo avanoa e fa'agasolo, ona su'esu'eina lea o le fofo o le oloa su'ega.O le chromatogram e faʻasaoina ma auʻiliʻili, e toesea le tumutumu avanoa, ma o le maualuga o le mama ma le tasi le mama iʻuga i luga o le chromatogram o le suʻega oloa o loʻo faʻamaumauina e ala i le eria masani.A mae'a le su'esu'ega, sa lolomi le chromatogram.
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Tausaga Aafiaga?E sili atu nai lo le 15 tausaga o le poto masani i le gaosiga ma le auina atu i fafo o le tele o tulaga maualuga o vailaʻau faʻapitoa poʻo vailaʻau lelei.
Maketi Autu?Faʻatau atu i maketi i totonu o le atunuʻu, Amerika i Matu, Europa, Initia, Korea, Iapani, Ausetalia, ma isi.
Tulaga lelei?Tulaga maualuga, tau taugofie, auaunaga faʻapolofesa ma lagolago faʻapitoa, vave tuʻuina atu.
Tulaga leleiFaamautinoaga?Fa'atonuga lelei faiga.O meafaigaluega faʻapitoa mo suʻesuʻega e aofia ai le NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Fa'ata'ita'iga?O le tele o oloa e maua ai faʻataʻitaʻiga e leai se totogi mo le iloiloga lelei, o tau o felauaiga e tatau ona totogi e tagata faʻatau.
Fale Su'etusi?Fa'afeiloa'i su'etusi falegaosimea.Fa'amolemole fai se taimi vave.
MOQ?Leai MOQ.Laititi oka e talia.
Taimi Tiliva? Afai o loʻo i totonu o faʻatauga, e tolu aso e faʻamaonia le tuʻuina atu.
Felauaiga?E ala ile Express (FedEx, DHL), ile Air, ile Sea.
Pepa?A maeʻa le faʻatau atu auaunaga: COA, MOA, ROS, MSDS, ma isi mea e mafai ona tuʻuina atu.
Tulaga Fa'apitoa?E mafai ona tu'uina atu au'aunaga tu'ufa'atasiga fa'apitoa e fetaui lelei ma au su'esu'ega mana'oga.
Tulaga Totogi?Proforma invoice o le a lafo muamua pe a maeʻa le faʻamaoniga o le poloaiga, faʻapipiʻi a matou faʻamatalaga faletupe.Totogi e le T / T (Telex Transfer), PayPal, Western Union, ma isi.
Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) o loʻo faʻaaogaina e avea o se mea faʻapitoa i le faʻaogaina o Apixaban (CAS: 503612-47-3).Apixaban ose ituaiga fou ole fa'aogaina ole fa'aogaina ole Xa fa'atasi fa'atasi e Bristol-Myers Squibb ma Pfizer.O le igoa tau fefa'ataua'iga o Erroto.Ose ituaiga fou ole oral anticoagulant.E ala i le taofiofia o se mea taua o le coagulation Xa, e mafai e apixaban ona puipuia le gaosiga o le thrombin ma le thrombosis.Apixaban na atiina ae e Bristal-Myers squibb Company.E iai le bioavailability lelei ma le filifilia maualuga.Na lisiina i Saina i le 2013. Apixaban e saogalemu, o le avanoa o fegalegaleaiga fualaau faasaina e laʻititi, ma e tele auala e faʻaumatia ai, lea e faʻamoemoeina e faʻaaogaina i vaega faʻapitoa e mafatia i le ate poʻo le faʻaleagaina o galuega o fatugaʻo.
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