CAS 361442-04-8 Mama >99.0% (HPLC) API

Fa'amatalaga Puupuu:

upu uiga tutusa: BMS-477118;Onglyza

CAS: 361442-04-8

Mama: >99.0% (HPLC)

Fa'aaliga: Pa'u Pa'epa'e

API, Tulaga Maualuga, Gaosiga Fa'apisinisi

E-Mail: alvin@ruifuchem.com

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Fa'amatalaga:

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Meatotino tau vailaau:

Synonyms	BMS-477118;Onglyza;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-Carbonitrile;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0]hexane -3-Carbonitrile
Numera CAS	361442-04-8
CAT Numera	RF-PI1991
Tulaga Fa'asoa	I Fa'atauga, Oloa Fua e O'o i Tone
Fuafua mole	C18H25N3O2
Molecular Weight	315.41
Fa'ailoga	Ruifu Chemical

Fa'amatalaga:

Aitema	Fa'amatalaga
Fa'aaliga	Pa'u Pa'epa'e
Sogisogi	Uiga
fa'ailoaga	A: IR B: Taimi Taofi HPLC
Mama / Suʻesuʻega Metotia	>99.0% (HPLC)
Malamalama ole Vai Fofo	E manino, e leai se lanu, e leai se mea e taofia
Su'esu'ega Fa'amama	100% Pass 80 Mesh
Lisi Lisi	202.0~212.0 ℃
Ma'imau ile Fa'amago	<0.50%
Sulphated Ash	<0.20%
Ta'amilosaga Fa'apitoa	+174.0°~+186.0°
Le mama nofofua	<0.50%
Aofa'i Fa'aleaga	<1.00%
Metala mamafa	<10ppm
Arsenic (As)	<2.0ppm
Ta'ita'i (Pb)	<1.0ppm
Cadmium (Cd)	<1.0ppm
Solvents totoe	<100ppm
Pesticide o totoe	Le lelei
Microbiology
Faitauga o Papatusi Aofa'i	<1000cfu/g
Faafefete & Mold	<100cfu/g
E. Coli	Le lelei
S. Aureus	Le lelei
Salmonella	Le lelei
Ola Fa'asa	24 Masina Mai le Aso Gauai pe a teu lelei
Tulaga Su'ega	Pisinisi Tulaga
Fa'aoga	API;Ituaiga 2 Ma'isuka Mellitus

Paket & Teuina:

afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau

Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu

Tulaga lelei:

FAQ:

Talosaga:

(BMS-477118) (CAS: 361442-04-8) o se malosi, filifili, toe faʻafoʻi, faʻatauvaʻa ma faʻamalosi tautala dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor.BMS-477118 ei ai le peotential mo suʻesuʻega o le maʻisuka ituaiga 2.BMS-477118o se vaila'au o le ma'isuka ituaiga 2 e mafai ona fa'aosofia ai le pancreas e gaosia atili le inisalini pe a uma le 'aiga.Na ausia e ala i le galulue faʻatasi a AstraZeneca ma Bristol-Myers Squibb Company ma o loʻo iai i le DPP-IV inhibitor.BMS-477118e faia le sao e ala i le taofiofia o le faʻaleagaina o le GLP-l.GLP-I o hormones e masani ona gaosia i totonu o le manava pe a uma ona 'ai.E mafai ona fa'atonutonu le fa'aliloina o le inisalini ma fa'amalosia le fa'aogaina o le kulukose i totonu o ga'o.Ole vaila'au e tasi ole BMS-477118 e mafai ona fa'aleleia ai le fa'atonutonuina ole kulukose ole toto ma ole tu'ufa'atasi ole vaila'au ole BMS-477118 fa'atasi ma Metformin, Sulfonylurea ma Thiazolidinediones e mafai ona fa'aleleia ai le a'afiaga.E taʻitaʻia ai le maualalo o le lamatiaga o le hypoglycemia ma o ona aʻafiaga leaga e tutusa ma placebo, faʻaalia ai le sili atu o le faapalepale.I le aso 31 o Iulai, 2009, BMS-477118 tablets (Onglyza), o se vailaʻau fou o le maʻisuka ituaiga 2, suʻesuʻe faʻatasi ma atinaʻe AstraZeneca ma Bristol-Myers Squibb na faʻamaonia e le US FDA.E mafai ona ave fa'atasi i le aso e togafitia ai le ma'i suka ituaiga 2 fa'atasi ma le puleaina o taumafa ma fa'amalositino.