5-(2-Pyridyl)-1,2-Dihydropyridin-2-one CAS 381233-78-9 Perampanel Intermediate Purity >98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o le 5-(2-Pyridyl) -1,2-Dihydropyridin-2-one ([2,3'-Bipyridin] -6'(1'H) -one) (CAS: 381233-78-9) faʻatasi ai ma tulaga maualuga, vaeluaga ole Perampanel (CAS: 380917-97-5).Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Perampanel intermediates,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | 5-(2-Pyridyl)-1,2-Dihydropyridin-2-tasi |
| Synonyms | [2,3'-Bipyridin]-6'(1'H)-tasi;5-(Pyridin-2-yl)pyridin-2(1H)-tasi;5-(Pyridin-2-yl)-2(1H)-Pyridone;5-(2-Pyridyl)pyridin-2(1H)-tasi;5-Pyridin-2-yl-1H-Pyridin-2-tasi;5-(Pyridin-2-yl)-1,2-Dihydropyridin-2-tasi;Perampanel le mama 1 |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 381233-78-9 |
| Fuafua mole | C10H8N2O |
| Molecular Weight | 172.18 g/mol |
| Lisi Lisi | 71.0~75.0 ℃ |
| Malosi | 1.221±0.06 g/cm3 |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Vaega | Intermediate of Perampanel (CAS: 380917-97-5) |
| Ola Fa'asa | 24 masina pe a teu lelei |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Pa'epa'e ile Toeitiiti Pa'epa'e Pa'u | Pa'u Pa'epa'e |
| Mama / Suʻesuʻega Metotia | >98.0% (HPLC) | 99.7% |
| Vai saunia e Karl Fischer | <1.00% | 0.58% |
| Le mama nofofua | <1.00% | E usitaia |
| Aofa'i Fa'aleaga | <2.00% | 0.30% |
| 1H NMR Alaleo | O gatasi ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
| Fa'atatauga | Intermediate of Perampanel (CAS: 380917-97-5) | |
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Solvent: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Ether, Petroleum Eteru, n-Hexane, Dichloromethane
Siaki: Mea Fa'atatau: Ave le oloa lenei ma fa'asusu i le vai fa'afefete (vai fe'avea'i: methanol (50∶50)) e fai ai se vaifofo e iai le 0.5mg i le 1ml e fai ma vaifofo o le oloa su'ega.E tusa ai ma le maualuga o le faʻaogaina o le chromatography vai (Chinese Pharmacopoeia 2010 Edition II Appendix Ⅴ D), o le silica gel (ZORBAX SB-C18 4.6 × 250mm,5m) na faʻaaogaina e fai ma faʻatumu.O le vaega feavea'i A o le vai, o le vaega feavea'i B o le methanol, ma o le umi o le galu e iloa ai o le 254nm.Ole fua ole tafe ole 1.0ml/min ma ole vevela ole koluma ole vevela ole potu.5μl ole su'ega fofo na fuaina sa'o ma tui ile chromatograph vai e fa'amaumau ai le chromatogram.E tusa ai ma le auala masani o le eria, o le anotusi o lenei oloa e le itiiti ifo i le 98%.Afai ei ai ni tumutumu le mama i le chromatogram o le vaifofo o oloa suʻega, o le vaega pito i luga ole eleelea e le tatau ona sili atu i le 1.0%, ma o le aofaʻi o le maualuga o le eleele e le tatau ona sili atu i le 2.0%.
Susū: Ave lenei oloa, faʻaaoga le suʻesuʻega o le susu, e tusa ai ma le auala a Karl Fischer (Chinese Pharmacopoeia 2010 lomiga II Faʻaopoopo Ⅷ M auala muamua A) faʻamoemoega, o le susu e le tatau ona sili atu i le 1.0%.
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5-(2-Pyridyl)-1,2-Dihydropyridin-2-one ([2,3'-Bipyridin]-6'(1'H)-tasi) (CAS: 381233-78-9), o se vaeluagalemu o Perampanel (CAS: 380917-97-5).O Perampanel (laisene i le 2012) o le tolu-tupulaga AED ua lauiloa ma le igoa faʻapitoa o Fycompa® (Eisai, Hatfield) i Peretania ma Banzel® (Eisai, Hatfield) i Amerika.Togafitiga fa'aopoopo o fa'alavelave fa'atosina fa'atasi ma le fa'agata fa'atosina lona lua ma le fa'ao'o fa'ato'aga fa'ato'aga muamua.Ia Oketopa 2012, na faʻamaonia ai e le US FDA le perampanel mo le togafitia o faʻalavelave faʻafuaseʻi i tagata gasegase epileptic e le itiiti ifo i le 12 tausaga.O Perampanel o le muamua AMPA e faʻafeiloaʻi faʻalavelave e maua le faʻamaoniga a le FDA o se AED.AMPA glutamate receptors e maua muamua ile postsynaptic neurons ile faiʻai.I le avea ai o se tagata fa'atauva'a, e le fa'atauva'a a le AMPA, o le parampanel e taofia ai le tatalaina o alalaupapa ion ma fa'aitiitia ai le fa'atupuina o gaioiga.
