4,4′-Bis(2-Bromoacetyl)biphenyl CAS 4072-67-7 Daclatasvir Dihydrochloride Intermediate Purity >98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o le 4,4'-Bis (2-Bromoacetyl) biphenyl (CAS: 4072-67-7) ma le maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau 4,4'-Bis(2-Bromoacetyl)biphenyl,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | 4,4'-Bis(2-Bromoacetyl)biphenyl |
| Synonyms | 4,4'-Bis(Bromoacetyl)biphenyl;1,1'-[1,1'-Biphenyl]-4,4'-diylbis[2-Bromoetana-1-tasi];Daclatasvir Le mama 7 |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 4072-67-7 |
| Fuafua mole | C16H12Br2O2 |
| Molecular Weight | 396.07 g/mol |
| Lisi Lisi | 226.0~227.0 ℃ |
| Malosi | 1.622±0.06 g/cm3 |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Vaega | Vaitaimi ole Daclatasvir Dihydrochloride (CAS: 1009119-65-6) |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga | I'uga |
| Fa'aaliga | Malosi | Malosi |
| Mama / Suʻesuʻega Metotia | >98.0% (HPLC) | 98.5% |
| Alaleo Infrared | O gatasi ma le Fauga | E usitaia |
| 1H NMR Alaleo | O gatasi ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
| Fa'atatauga | Vaitaimi ole Daclatasvir Dihydrochloride (CAS: 1009119-65-6) | |
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4,4'-Bis(2-Bromoacetyl)biphenyl (CAS: 4072-67-7) o se vaeluaga ole Daclatasvir Dihydrochloride (CAS: 1009119-65-6).
Daclatasvir Dihydrochloride (Daklinza) o se inhibitor o le hepatitis C virus (HCV) NS5A lea e aoga i le togafitiga o genotype 3 faʻamaʻi pipisi hepatitis C.
I le aso 24 o Iulai, 2015, na faʻamaonia ai e le FDA le vailaʻau faʻamaʻi hepatitis C (Bristol-Myers Squibb) mo le maketiina.
O le faagasologa o le faamaoniga a le FDA a Daklinza (Bristol-Myers Squibb) ua fefiloi ma feliuliuai.Ua uma ona teena e le FDA, ae mulimuli ane faamaonia i le ogatotonu o le 2015.Na faʻamaonia e le FDA le tuʻufaʻatasiga o Daklinza ma Sofosbuvir mo le togafitia o gasegase o le hepatitis C gene type 3.
O le mea moni, i le amataga aʻo leʻi faʻatagaina le FDA, na faʻamaonia Daklinza mo le maketiina i Iapani, Europa Europa ma Korea i Saute ma isi atunuu.I le 2014, na faʻamaonia e le vaega o le soifua maloloina Iapani le talosaga a Daklinza ma Asunaprevir (Sunvepra) mo le togafitia o faʻamaʻi pipisi o le genotype 1.Na faʻatagaina foi e le Iuni a Europa le Daclatasvir e faʻaaogaina faʻatasi ma isi vailaʻau i le togafitiga o HCV genotypes 1, 2, 3 ma 4 i le 2014. O Daclatasvir o le NS5A faʻalavelave faʻalavelave muamua na faʻatagaina e Europa (EU).Pe a faʻaaogaina faʻatasi ma isi vailaʻau, faʻatusatusa i togafitiga faʻatasi o le interferon ma le ribavirin lea e 48 vaiaso, e puupuu le umi o togafitiga (12 vaiaso poʻo le 24 vaiaso).
Daclathavir monotherapy e le fautuaina, o le faʻasologa masani o loʻo i ai nei o le tuʻufaʻatasiga o togafitiga o Dacastavir + Sofosbuvir, lea e faʻaalia i le aoga lelei, maualuga SVR, aʻafiaga laiti ma faʻapuupuuina le taamilosaga o togafitiga nai lo isi filifiliga.
