Apixaban Intermediate CAS 545445-44-1 Mama>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. o le ta'ita'i gaosi oloa 3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 545445 -44-1) faʻatasi ai ma tulaga maualuga, vaeluaga o Apixaban (CAS: 503612-47-3).Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Apixaban Intermediates,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | 3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-tasi |
| Synonyms | Apixaban Intermediate 1;5,6-Dihydro-3-(4-Morpholinyl)-1-[4-(2-Oxo-1-Piperidinyl)phenyl]-2(1H)-Pyridinone;5-Morpholin-4-yl-1-[4-(2-Oxopiperidin-1-yl)phenyl]-2,3-Dihydropyridin-6-one;Apixaban le mama A |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 545445-44-1 |
| Fuafua mole | C20H25N3O3 |
| Molecular Weight | 355.43 g/mol |
| Lisi Lisi | >199℃(Tes.) |
| Malosi | 1.267 g/mL |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Vaega | Intermediate of Apixaban (CAS: 503612-47-3) |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga | I'uga |
| Fa'aaliga | Pata Samasama Malamalama | Pata Samasama Malamalama |
| Ma'imau ile Fa'amago | <0.50% | 0.16% |
| Toega i luga o le mumu | <0.20% | 0.07% |
| Mama / Suʻesuʻega Metotia | >98.0% (Vaega HPLC) | 99.12% |
| So'o se Fa'aleaga Ta'ito'atasi | <0.50% | <0.50% |
| Aofa'i Fa'aleaga | <2.00% | 0.88% |
| 1H NMR Alaleo | O gatasi ma le Fauga | Fa'atatau |
| LC-MS mo le Faailoaina | Fa'atatau | Fa'atatau |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
| Fa'atatauga | Intermediate of Apixaban (CAS: 503612-47-3) | |
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3-Morpholino-1-(4-(2-Oxopiperidin-1-yl) phenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 545445-44-1) o se vaeluagalemu o Apixaban (CAS: 503612-47-3).
O le Apixaban ose ituaiga fou ole fa'aogaina ole Xa factor fa'atasi na fausia fa'atasi e Bristol-Myers Squibb ma Pfizer.O le igoa tau fefa'ataua'iga o le Eratol, o se ituaiga fou o le oral anticoagulant.E ala i le taofiofia o se mea taua o le coagulation Xa, e mafai e Apixaban ona puipuia le gaosiga o le thrombin ma le thrombosis.O Aperila 26, 2007, Bristol-Myers Squibb na faʻatasi ma Pfizer e faʻasalalau le galulue faʻatasi i le atinaʻeina o se Apixaban oral anticoagulant fou o loʻo umia e Bristol-Myers Squibb o se suiga faʻaleleia i Warfarin.I le masina o Me 2011, o Apixaban na muamua faʻamaonia le puipuia o le thrombosis venous i tagata matutua o loʻo faia le taotoga suilapalapa poʻo tulivae i 27 EU atunuu, Iceland ma Nouei.I le aso 20 o Novema, 2012, na faʻamaonia ai e le Komisi Europa Ererto (Apixaban) mo le puipuia o le stroke ma le faʻaogaina o le tino i tagata matutua maʻi e leai ni valvular atrial fibrillation (NVAF) faʻatasi ai ma se tasi pe sili atu tulaga lamatia.Mulimuli ane, na faʻamaonia e le Canadian Food and Drug Administration, Iapani, ma le US FDA Ererto (Apixaban) mo le puipuia o le stroke ma le faʻaogaina o le tino i tagata matutua maʻi e leai ni valvular atrial fibrillation (NVAF) ma se tasi pe sili atu mea lamatia.O Aperila 12, 2013, o le vailaʻau faʻamaʻi fou Eloto (ELIQUIS) (Apixaban) na fausia faʻatasi e Bristol-Myers Squibb ma Pfizer na faʻasalalau aloaia e lisiina i Saina.
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