TMC207 CAS 843663-66-1 Mama>99.5% (HPLC)
TMC207 Feso'ota'iga Fa'atatau:
TMC207 CAS 843663-66-1
3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2
3-Benzyl-6-Bromo-2-Methoxyquinoline CAS 654655-69-3
| Igoa Vailaau | TMC207 |
| Synonyms | TMC-207, R207910;Sirturo;(αS,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1-(6-Bromo-2-methoxyquinolin-3-yl) -4-dimethylamino-1-phenyl-2-(1-naphthyl) 2-butanol |
| Numera CAS | 843663-66-1 |
| CAT Numera | RF2336 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C32H31BrN2O2 |
| Molecular Weight | 555.516 |
| Lisi Lisi | 104℃ |
| Malosi | 1.322±0.06 g/cm3 |
| Ma'ale'ale | Hygroscopic.Ma'ale'ale ma'ale'ale, Ea maaleale |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e po'o le Pa'epa'e Pa'epa'e |
| Mama / Suʻesuʻega Metotia | >99.5% (HPLC) |
| Ma'imau ile Fa'amago | <0.50% |
| Toega i luga o le mumu | <0.20% |
| So'o se Fa'aleaga Ta'ito'atasi | <0.10% |
| Isomer | <0.10% |
| Aofa'i Fa'aleaga | <0.50% |
| Metala mamafa (pei o le Pb) | <20ppm |
| Arsenic (As) | <2.0ppm |
| Alaleo Infrared | E tusa ma le Fauga |
| Proton NMR Alaleo | E tusa ma le Fauga |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | API |
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(CAS: 843663-66-1), (ua taʻua o le TMC207 ma le R207910), faʻatau i lalo o le igoa tau fefaʻatauaʻiga Sirturo, o se tala fou diarylquinoline antimycobacterial vailaʻau e aʻafia ai le mamapala e ala i le taofia o le gaioiga a le M. tuberculosis ATP synthase proton pamu.O le fa'asologa o le ATP o le mycobacteria e fa'aalia ai a'afiaga fa'ama'i ma fa'ama'i.Fa'aa'i fa'apitoa e togafitia ai le mamapala mo tagata matutua e tete'e i vaila'au (MDR-PTB).TMC207 o loʻo i ai le gaioiga faʻamaʻi tutusa e faasaga i M. tuberculosis maʻaleʻale maʻaleʻale faʻamaʻi, ma e iai foi se aafiaga lelei sterilization i siama moe.Ia Tesema 2012, na fa'amaonia ai e le US FDA le TMC207 o se vaega o togafitiga tu'ufa'atasi mo togafitiga o le mamapala e tete'e atu i fualaau fa'asaina (MDRTB).O le TMC207 o le vaila'au muamua ua fa'amaonia mo le MDR-TB ma o le fa'atagaga muamua lea mai se vasega fou o vaila'au fa'ama'i fa'ama'i i le 40 tausaga talu ai.Ona o le maualuga o le mana'oga fa'afoma'i mo le togafitia o le MDR-TB, na tu'uina atu ai e le FDA le fa'atagaga fa'avavevave a le TMC207 e fa'atatau i fa'ai'uga o le Vaega II, e maua ai e tagata gasegase le avanoa i le vaila'au a'o faia su'esu'ega fa'apitoa.O le TMC207 o se diarylquinoline na maua mai i se ta'iala e su'esu'e ai le tino atoa ma le Mycobacterium smegmatis na fa'aaogaina e fai ma sui mo le M. tuberculosis.TMC207 ose tasi enantiomer o se uluai su'esu'ega lavea.O le TMC207 o lo'o i ai se gaioiga malosi ma le filifilia e tetee atu ai i le mycobacteria, ma o lo'o galue malosi e tetee atu i vaila'au ma'ale'ale M. tuberculosis.Ole faiga ole gaioioiga ole TMC207 e tulaga ese ile vaila'au fa'ama'i TB ma e aofia ai le fa'asaina ole mycobacterial ATP synthase;e le o malosi i le tagata ATP synthase.O le TMC207 o lo'o i totonu o le vivo gaioiga i le tele o fa'ata'ita'iga fa'apitoa o fa'ama'i TB, na'o le tu'ufa'atasia ma isi vaila'au fa'ama'i TB, ma e iai le gaioiga fa'ama'i i fa'ata'ita'iga fa'ama'i pipisi.TMC207 o loʻo faʻapipiʻiina i laasaga e lima mai le 3-Phenylpropionic Acid ma le para-Bromoaniline.I le maeʻa ai o le faʻavaeina o le amide, togafitiga ma POCl3 ma DMF i lalo ole Vilsmeier-Hack tulaga na maua ai se oloa 2-Chloroquinoline.Togafitiga i le sodium methoxide, sosoo ai ma le condensation ma le 3-(Dimethylamino) -1-(naphthalen-1-yl) propan-1-one, ma le vavaeeseina o isomers na maua ai le TMC207.
