Crizotinib Intermediate CAS 877399-00-3 Mama ≥98.0% (HPLC) ee ≥99.0%
Shanghai Ruifu Chemical Co., Ltd. o le ta'ita'i gaosi oloa (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00 -3) faʻatasi ai ma tulaga maualuga, vaeluaga ole Crizotinib (CAS: 877399-52-5).Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Crizotinib Intermediate,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine |
| Synonyms | Crizotinib Intermediate;Crizotinib Bromide le mama;5-Bromo-3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]-2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amine |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 877399-00-3 |
| Fuafua mole | C13H10BrCl2FN2O |
| Molecular Weight | 380.04 g/mol |
| Lisi Lisi | 108.0 i le 113.0 ℃ |
| Malosi | 1.643 |
| COA & MSDS | Avanoa |
| Fa'ata'ita'iga | Avanoa |
| Amataga | Shanghai, Saina |
| Vaega | Intermediate o Crizotinib (CAS: 877399-52-5) |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Samasama Malamalama I Samasama Pata i Crystal | E usitaia |
| Lisi Lisi | 108.0 i le 113.0 ℃ | E usitaia |
| Mama (Vaega HPLC) | ≥98.0% | 99.1% |
| Enantiomeric Excess (EE) | ≥99.0% | 99.5% |
| Alaleo Infrared | E tusa ma le Fauga | E usitaia |
| 1 H NMR Alaleo | E tusa ma le Fauga | E usitaia |
| Fa'ai'uga | O lenei oloa ua uma ona faʻataʻitaʻiina ma tausisia faʻamatalaga | |
| Ola Fa'asa | 2 Tausaga pe a teu lelei | |
afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Taofi mau le atigipusa ma teu i totonu o se faleteuoloa malulu, mago (2~8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Tausaga Aafiaga?E sili atu nai lo le 15 tausaga o le poto masani i le gaosiga ma le auina atu i fafo o le tele o tulaga maualuga o vailaʻau faʻapitoa poʻo vailaʻau lelei.
Maketi Autu?Faʻatau atu i maketi i totonu o le atunuʻu, Amerika i Matu, Europa, Initia, Korea, Iapani, Ausetalia, ma isi.
Tulaga lelei?Tulaga maualuga, tau taugofie, auaunaga faʻapolofesa ma lagolago faʻapitoa, vave tuʻuina atu.
Tulaga leleiFaamautinoaga?Fa'atonuga lelei faiga.O meafaigaluega faʻapitoa mo suʻesuʻega e aofia ai le NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Fa'ata'ita'iga?O le tele o oloa e maua ai faʻataʻitaʻiga e leai se totogi mo le iloiloga lelei, o tau o felauaiga e tatau ona totogi e tagata faʻatau.
Fale Su'etusi?Fa'afeiloa'i su'etusi falegaosimea.Fa'amolemole fai se taimi vave.
MOQ?Leai MOQ.Laititi oka e talia.
Taimi Tiliva? Afai o loʻo i totonu o faʻatauga, e tolu aso e faʻamaonia le tuʻuina atu.
Felauaiga?E ala ile Express (FedEx, DHL), ile Air, ile Sea.
Pepa?A maeʻa le faʻatau atu auaunaga: COA, MOA, ROS, MSDS, ma isi mea e mafai ona tuʻuina atu.
Tulaga Fa'apitoa?E mafai ona tu'uina atu au'aunaga tu'ufa'atasiga fa'apitoa e fetaui lelei ma au su'esu'ega mana'oga.
Tulaga Totogi?Proforma invoice o le a lafo muamua pe a maeʻa le faʻamaoniga o le poloaiga, faʻapipiʻi a matou faʻamatalaga faletupe.Totogi e le T / T (Telex Transfer), PayPal, Western Union, ma isi.
(R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00-3) o loʻo faʻaaogaina e avea o se vaeluaga ole Crizotinib (CAS: 877399-52-5).
O le Crizotinib e mautinoa lava o se vailaʻau faʻamaʻi kanesa ua avea ma alk (anaplastic lymphoma kinase) ma ros1 (c-ros oncogene 1) inhibitor, faʻamaonia mo togafitiga o nisi o le tino e le o ni sela mama (NSCLC) i Amerika ma isi atunuu, ma o lo'o faia le tele o su'esu'ega e su'e ai lona saogalemu ma le aoga i anaplastic large cell lymphoma, neuroblastoma, ma isi tuma malosi i tagata matutua ma tamaiti.
O le Crizotinib o se vailaʻau faʻapitoa mo togafitiga mo le kanesa o le mama sela laiti na atiaʻe e Pfizer, ISA, o secorri o se tuaoi ma epoch-faia vailaʻau i le matata o togafitiga faʻatatau mo le kanesa o le mama.Na fa'amaonia mo le maketiina i le Iunaite Setete ia Aukuso 2011 ma sa tusia i ta'iala fa'ava-o-malo mo le kanesa o le mama i le fa'ai'uga o le tausaga e avea o se vaila'au muamua mo tagata mama'i ALK.Faʻamaonia faʻatasi ma Crizotinib o le faʻataʻitaʻiga muamua lea e faʻaaogaina ai le fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, o le auala lea o loʻo faʻaaogaina nei i suʻesuʻega faʻapitoa i le lalolagi e suʻe ai kenera fusi EML4-ALK i le NSCLC.O lenei su'ega o le a fesoasoani e iloa ai tagata mama'i e mafai ona manuia mai togafitiga Crizotinib.
O le Crizotinib o se fa'ainitaneti fa'atosina o le tyrosine kinase e fa'aaogaina i le togafitiga o mataupu filifilia o le kanesa o le mama mama e le o ni mea laiti.O se fa'atauva'a fa'atauva'a ATP lua o tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) ma le ALK (cellular IC50 = 20 nM), o ia mea uma e lua o sini taua mo le kanesa chemotherapy.Ina ua tofotofoina Crizotinib mo le filifilia ma isi kinases na maua ai le enzyme IC50's i totonu o le 100-fold multiples o c-MET mo le 13 o le 120 kinases na suʻeina.I suʻesuʻega feaveaʻi, na maua ai le Crizotinib e taofia le RON (recepteur d'origine nantais) kinase faʻatasi ai ma le 10-fold selectivity window i luga ole c-MET.I le aotelega, o lenei vailaʻau e faʻalavelaveina le tuputupu aʻe o sela tumo.XALKORI®(Crizotinib) ose vaila'au fa'atonu e fa'aaogaina e togafitia ai tagata e maua i le kanesa o le mama sela (NSCLC) lea ua sosolo atu i isi vaega o le tino ma e mafua mai i se fa'aletonu i se gene e ta'ua ALK (anaplastic lymphoma kinase) po'o se kenera e ta'ua o le ROS1.E le o iloa pe saogalemu ma aoga le XALKORI i tamaiti.
