1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Mama ≥98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o le 1-Boc-4-(4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) faʻatasi ai ma le maualuga, vaeluaga ole Crizotinib (CAS: 877399- 52-5).Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine |
| Synonyms | Crizotinib-D;tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl) piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino)-4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;tert-butyl 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;1-(4-Boc-1-Piperidinyl)-4-Bromopyrazole;Crizotinib le mama 4 |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 877399-50-3 |
| Fuafua mole | C13H20BrN3O2 |
| Molecular Weight | 330.23 g/mol |
| Lisi Lisi | 77.0 i le 81.0 ℃ |
| Malosi | 1.43 |
| Solubility | Solu i le Methanol |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Vaega | Intermediate of Crizotinib (CAS: 877399-52-5) |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Pa'epa'e Malosi | Pa'epa'e Malosi |
| Lisi Lisi | 77.0 i le 81.0 ℃ | E usitaia |
| Vai saunia e Karl Fischer | <0.50% | 0.11% |
| Mama / Suʻesuʻega Metotia | ≥98.0% (HPLC) | 99.3% |
| 1H NMR Alaleo | E tusa ma le Fauga | E usitaia |
| Misasa | E tusa ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Taofi mau le atigipusa ma teu i totonu o se faleteuoloa malulu, mago (2~8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Tausaga Aafiaga?E sili atu nai lo le 15 tausaga o le poto masani i le gaosiga ma le auina atu i fafo o le tele o tulaga maualuga o vailaʻau faʻapitoa poʻo vailaʻau lelei.
Maketi Autu?Faʻatau atu i maketi i totonu o le atunuʻu, Amerika i Matu, Europa, Initia, Korea, Iapani, Ausetalia, ma isi.
Tulaga lelei?Tulaga maualuga, tau taugofie, auaunaga faʻapolofesa ma lagolago faʻapitoa, vave tuʻuina atu.
Tulaga leleiFaamautinoaga?Fa'atonuga lelei faiga.O meafaigaluega faʻapitoa mo suʻesuʻega e aofia ai le NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Fa'ata'ita'iga?O le tele o oloa e maua ai faʻataʻitaʻiga e leai se totogi mo le iloiloga lelei, o tau o felauaiga e tatau ona totogi e tagata faʻatau.
Fale Su'etusi?Fa'afeiloa'i su'etusi falegaosimea.Fa'amolemole fai se taimi vave.
MOQ?Leai MOQ.Laititi oka e talia.
Taimi Tiliva? Afai o loʻo i totonu o faʻatauga, e tolu aso e faʻamaonia le tuʻuina atu.
Felauaiga?E ala ile Express (FedEx, DHL), ile Air, ile Sea.
Pepa?A maeʻa le faʻatau atu auaunaga: COA, MOA, ROS, MSDS, ma isi mea e mafai ona tuʻuina atu.
Tulaga Fa'apitoa?E mafai ona tu'uina atu au'aunaga tu'ufa'atasiga fa'apitoa e fetaui lelei ma au su'esu'ega mana'oga.
Tulaga Totogi?Proforma invoice o le a lafo muamua pe a maeʻa le faʻamaoniga o le poloaiga, faʻapipiʻi a matou faʻamatalaga faletupe.Totogi e le T / T (Telex Transfer), PayPal, Western Union, ma isi.
Fa'ailoga Mata'utia Xn - Fa'aleagaina
Fa'ailoga Tulaga 22 - E afaina pe a folo
1-Boc-4-(4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) o loʻo faʻaaogaina e avea o se vaeluaga ole Crizotinib (CAS: 877399-52-5).Crizotinib (igoa fefa'ataua'iga Xalkori,) o se vaila'au fa'ama'i-kanesa o lo'o galue o se ALK (anaplastic lymphoma kinase) ma le ROS1 (c-ros oncogene 1) inhibitor, fa'amaonia mo le togafitia o nisi o le tino mama o le tino (NSCLC) i le US. ma isi atunu'u, ma fa'ata'ita'iina fa'ata'ita'iga fa'ata'ita'iga e fa'ata'ita'i ai lona saogalemu ma le aoga ole lymphoma sela tele inanaplastic, neuroblastoma, ma isi tuma ma'a'a maualuga i tagata matutua ma tamaiti.
Ia Aukuso 2011, na fa'amaonia ai e le FDA a le Iunaite Setete le Crizotinib (PF-02341066) mo le togafitia o anaplastic lymphoma kinase (ALK) toe fa'atulagaina le kanesa o le mama e le o ni sela laiti (NSCLC).Crizotinib o se fa'atauva'a fa'atauva'a ATP lua o tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) ma le ALK (cellular IC50 = 20 nM), o ia mea uma e lua o sini taua mo le kanesa chemotherapy.Ina ua tofotofoina Crizotinib mo le filifilia ma isi kinases na maua ai le enzyme IC50's i totonu o le 100-fold multiples o c-MET mo le 13 o le 120 kinases na suʻeina.I suʻesuʻega feaveaʻi, na maua ai le Crizotinib e taofia le RON (recepteur d'origine nantais) kinase faʻatasi ai ma le 10-fold selectivity window i luga ole c-MET.
