CAS 945667-22-1 Mama >99.0% (HPLC) API

Fa'amatalaga Puupuu:

CAS: 945667-22-1

Mama: >99.0% (HPLC)

Fa'aaliga: Pa'u Pa'epa'e

API, Tulaga Maualuga, Gaosiga Fa'apisinisi

E-Mail: alvin@ruifuchem.com

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2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Meatotino tau vailaau:

Synonyms	BMS-477118 Suavai;Onglyza Hydrate;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ]hexane-3-Carbonitrile Hydrate
Numera CAS	945667-22-1
CAT Numera	RF-PI1992
Tulaga Fa'asoa	I Fa'atauga, Oloa Fua e O'o i Tone
Fuafua mole	C18H25N3O2·H2O
Molecular Weight	333.43
Fa'ailoga	Ruifu Chemical

Fa'amatalaga:

Aitema	Fa'amatalaga
Fa'aaliga	Pa'u Pa'epa'e
fa'ailoaga	A: IR B: Taimi Taofi HPLC
Mama / Suʻesuʻega Metotia	>99.0% (HPLC, I luga o Fa'amago)
Suavai (KF)	5.3%~7.3%
Toega i luga o le mumu	<0.20%
Le mama nofofua	<0.50%
Aofa'i Fa'aleaga	<1.00%
Metala mamafa	<10ppm
Arsenic (As)	<2ppm
Microbiology
Faitauga o Papatusi Aofa'i	<1000cfu/g
Faafefete & Mold	<100cfu/g
E. Coli	Le lelei
S. Aureus	Le lelei
Salmonella	Le lelei
Ola Fa'asa	24 masina
Tulaga Su'ega	Pisinisi Tulaga
Fa'aoga	API;Fa'aaogaina mo togafitiga o le ma'isuka ituaiga II

Paket & Teuina:

afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau

Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu

Tulaga lelei:

FAQ:

Talosaga:

API (CAS: 945667-22-1) ose dipeptidyl peptidase-4 (DPP4) inhibitor filifilia ma mafai ona faʻaaogaina e mafai ona faʻaaogaina e atiaʻe ai togafitiga mo le maʻisuka ituaiga 2.O se faʻamaufaʻailoga DPP4 filifilia ma faʻaaogaina ma le IC50 o le 26 nM ma le Ki o le 1.3 nM.IC50 tau: 26 nM.Sini: DPP4 in vitro: O loʻo i ai se faʻalavelave tumau Ki o le 1.3 nM mo le faʻasaina DPP4, lea e 10-paiga sili atu le malosi nai lo Sitagliptin (isi lua DPP4 inhibitors) ma Ki o 13 ma 18 nM.E le gata i lea, O loʻo faʻaalia ai le faʻamaonia sili atu mo le DPP4 nai lo le DPP8 poʻo le DPP9 enzymes (400- ma le 75-fold, i le faasologa).O le metablite malosi o ia e faalua ona itiiti le malosi nai lo le matua.O mea uma e lua (CAS: 945667-22-1) ma lona metabolite e sili ona filifilia (> 4000-fold) mo le puipuia o le DPP4 pe a faʻatusatusa i le tele o isi protease.(CAS: 945667-22-1) faʻaitiitia le faʻaleagaina o le incretin hormone glucagon-like peptide-1, ma faʻaleleia ai ana gaioiga, ma e fesoʻotaʻi ma le faʻaleleia o le β-cell function ma le taofiofia o le glucagon secretion.in vivo: E matua aoga tele. i le fa'ailoaina o fa'aopoopoga fa'alagolago i fuala'au fa'atatau ile kilia ole kulukose ile fua ole fua ole 0.13-1.3 mg/kg ile ob/ob isumu e fa'atatau ile pulea.