Celecoxib CAS 169590-42-5 Su'ega 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Celecoxib (CAS: 169590-42-5) faʻatasi ai ma tulaga maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Celecoxib,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Celecoxib |
| Synonyms | Celebrex;Celebra;Selecox;Onsenal;Solexa;SC-58635;SC 58635;YM-177;4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-yl]benzenesulfonamide;5-(4-Methylphenyl)-1-(4-Sulfamoylphenyl)-3-(Trifluoromethyl)pyrazole |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 169590-42-5 |
| Fuafua mole | C17H14F3N3O2S |
| Molecular Weight | 381.37 g/mol |
| Lisi Lisi | 160.0 i le 165.0 ℃ |
| Malosi | 1.43±0.10g/cm3 |
| Suavai Solubility | E le mafai ona solu i le Vai |
| Solubility | E matua solu i le Methanol;Solu i le Ethanol |
| COA & MSDS | Avanoa |
| Fa'ata'ita'iga | Avanoa |
| Amataga | Shanghai, Saina |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Pa'epa'e po'o le Toeitiiti Pa'epa'e Pa'u tioata | E usitaia |
| Su'ega | 98.0~102.0% | 99.8% |
| Lisi Lisi | 160.0 i le 165.0 ℃ | 162.2℃ |
| Vai saunia e Karl Fischer | <0.50% | 0.11% |
| Toega i luga o le mumu | <0.20% | 0.05% |
| Metala mamafa (Pb) | ≤20ppm | <10ppm |
| Celecoxib Related Compound A | <0.40% | <0.20% |
| Celecoxib Related Compound B | <0.10% | <0.10% |
| Tagata Ta'ito'atasi Le Fa'amamafaina Le Mama | <0.10% | <0.10% |
| Aofa'i le mama | <0.50% | 0.20% |
| Alaleo Infrared | Ia ogatasi ma le Fauga | E usitaia |
| 1H NMR Alaleo | Ia ogatasi ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
afifi:Fa'ato'aga Fa'alili, Ato pepa alumini, 25kg/Cardboard Drum, pe tusa ai ma mana'oga o tagata fa'atau.
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Celecoxib
C17H14F3N3O2S 381.4
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide [169590-42-5]
FAAMATALAGA
Celecoxib o loʻo i ai le NLT 98.0% ma le NMT 102.0% o le C17H14F3N3O2S, faʻatatau i luga o le faʻavae anhydrous.
FAATINOGA
• A. INFRARED absorption <197>: [FAATUATUA-Metotia <197A>, <197K>, po'o le <197M> i lalo ole Infrared Absorption e mafai ona fa'aoga.]
[FAAMANATU-Afai o le fusi o alaleo na maua e faʻaalia ai le eseesega, faʻamavae le mea e suʻesuʻe ma le Faʻamatalaga Faʻamatalaga eseese i le isopropyl alcohol, faʻagogo i le mago, ma faʻamaumau le spectra fou.]
• B. O le taimi fa'atumauina o le tumutumu tele o le fofo Fa'ata'ita'i e fetaui ma le vaifofo masani, e pei ona maua i le Su'ega.
SU'ESU'EGA
• TULAGA
Pa'u: 2.7 g/L ole monobasic potassium phosphate fa'afetaui ile phosphoric acid ile pH ole 3.0 ± 0.2
Vaega feavea'i: Methanol, acetonitrile, ma le Pa'u (3:1:6)
Suavai: Methanol ma vai (3:1)
Fofo fa'aoga talafeagai: 0.5 mg/mL o le USP
Celecoxib RS ma le 2.4 µg/mL ta'itasi USP Celecoxib Fa'afefiloi Fa'atatau A RS ma USP Celecoxib Fa'atatau B RS i le fa'afefiloi.
Fofo masani: 0.5 mg/mL o le USP Celecoxib RS ile Diluent
Fa'ata'ita'iga fofo: 0.5 mg/mL o le Celecoxib i le Diluent
Faiga fa'akomepiuta
(Va'ai Chromatography <621>, Faiga Fa'atonu.)
Auala: LC
Su'esu'e: UV 215 nm
Koluma: 4.6-mm × 25-cm;5-µm fa'apipi'i L11
vevela o le koluma: 60°
Fuafuaga tafe: 1.5 mL/min
Tele tui: 25 µL
Taimi tamo'e: E tusa ma le 1.5 taimi ole fa'aoso ole celecoxib peak elution
Faiga talafeagai
Fa'ata'ita'iga: Fa'atonuga fa'aoga vaifofo ma fofo Fa'atonu
Mana'oga talafeagai
I'uga: NLT 1.8 i le va o le celecoxib feso'ota'iga fa'atasi A ma le Celecoxib ma le NLT 1.8 i le va o le Celecoxib ma le Celecoxib feso'ota'iga fa'atasi B, Fa'atonu fa'aoga fofo.
Feso'ota'iga tulaga fa'atatau: NMT 0.73%, Fofo fa'ata'atia
Iloiloga
Faʻataʻitaʻiga: Fofo masani ma Faʻataʻitaʻiga fofo
Fa'atatau le pasene ole C17H14F3N3O2S ile vaega ole Celecoxib na ave:
I'uga = (rU/rS) × (CS/CU) × 100
rU = tali maualuga mai le faʻataʻitaʻiga fofo
rS = tali pito i luga mai le fofo masani
CS = fa'atonuga o le vaifofo masani (mg/mL)
CU = fa'atonuga o le fa'ata'ita'iga fofo (mg/mL)
Tulaga taliaina: 98.0% ~ 102.0% i luga o le anhydrous faavae
LELEI
Fa'aleaga Fa'aletino
• METAL MAMAFA: NMT 20 ppm
Suavai: Acetone ma vai (17:3)
Fofo masani: Fa'asusu le 1.0 mL o le Fofo Ta'ita'i Ta'ita'i, saunia e pei ona fa'atonuina i lalo o Metala Mamafa <231>, Mea Fa'apitoa Fa'apitoa, fa'atasi ai ma le Su'e i le 20 mL.
Fa'ata'ita'iga fofo: Fa'amuta le 0.50 g o le Celecoxib i le 20mL o le Diluent.
Fofo avanoa: 20 mL o Diluent
Iloiloga
Fa'ata'ita'iga: Fofo masani, Fofo avanoa, ma Fa'ata'ita'i fofo
I vaifofo ta'itasi, fa'aopoopo i ai le 2 mL o le pH 3.5 Acetate Buffer ua saunia e pei ona fa'atonuina i lalo o Metala Mamafa <231>, Metotia I. Fa'afefiloi, ma fa'aopoopo i fofo ta'itasi le 1.2 mL o le thioacetamide-glycerin base TS.Faafefiloi vave, ma tuu e tu mo le 2 min.Tufa vaifofo ile faamama ole pore 0.45-µm.Fa'atusatusa togi i luga o fa'amama na maua mai fofo ta'itasi.
Tulaga talia: O le lanu enaena-uliuli o le mea e maua mai i le Fa'ata'ita'iga fofo e le sili atu le malosi nai lo le mea o lo'o maua mai i le vaifofo masani.E le aoga le su'ega pe a le fa'aalia e le vaifofo masani se lanu enaena-uliuli pe a fa'atusatusa i le vaifofo Avanoa.
• TOE I LE FA'AVAE <281>: NMT 0.2%, fa'aaoga se fa'apalapala.
Oona Fa'aleaga
• TULAGA
Pa'u, Vaega feavea'i, Diluent, Fofo talafeagai o faiga, Fa'ata'ita'i fofo, ma le Chromatographic system: Fa'agasolo e pei ona fa'atonuina i le Su'ega.
Fofo masani: 0.5 µg/mL o le USP Celecoxib RS ile Diluent
Faiga talafeagai
Fa'ata'ita'iga: Fa'atonuga fa'aoga vaifofo ma fofo Fa'atonu
Mana'oga talafeagai
I'uga: NLT 1.8 i le va o Celecoxib feso'ota'iga fa'atasi A ma Celecoxib ma NLT 1.8 i le va o Celecoxib ma Celecoxib feso'ota'i fa'atasi B, Fa'atonuga fa'aoga fofo.
Fa'ailoga fa'ailoga-i-leo: NLT 20, Fofo masani
Iloiloga
Faʻataʻitaʻiga: Fofo masani ma Faʻataʻitaʻiga fofo
Fa'atatau le pasene o mea leaga ta'itasi ile vaega ole Celecoxib na ave:
I'uga = (rU/rS) × (CS/CU) × 100
rU = tali pito i luga mo le mama taʻitasi i le faʻataʻitaʻiga fofo
rS = tali maualuga o le celecoxib i le vaifofo Tulaga
CS = fa'atonuga o le celecoxib i le fofo masani (mg/mL)
CU = fa'atonuga o le Celecoxib i le fa'ata'ita'iga fofo (mg/mL)
Tulaga taliaina
O eleelea ta'ito'atasi: Va'ai le Laulau 1.
[FAATUATUA-Ia le amana'ia so'o se tumutumu eleelea e itiiti ifo i le 0.05%.]
Laulau 1
| Igoa | Taimi Fa'amaufa'atasiga | Ta'iala Talia NMT (%) |
| Celecoxib feso'ota'iga fa'atasi Aa | 0.9 | 0.4 |
| Celecoxib | 1.0 | — |
| Celecoxib feso'ota'iga tu'ufa'atasi Bb | 1.1 | 0.10 |
| Le fa'aleaogaina o tagata ta'ito'atasi | — | 0.10 |
| Aofa'i le mama | — | 0.5 |
a 4-[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
b 4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
SU'E FA'AMANATU
• FA'IFUAINA O LE SUAI, Metotia I <921>: NMT 0.5%, fa'aaoga se fa'ata'ita'iga 400-mg
FAAOPOOPOGA
• FA'A'U'U MA TE'UINA: Fa'asao i totonu o atigipusa fufusi, puipuia mai le malamalama ma le susu.Teu i le vevela o le potu
• USP REFERENCE STANDARD <11>
USP Celecoxib RS
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
C17H14F3N3O2S 381.4
USP Celecoxib Related Compound A RS
4-[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
C17H14F3N3O2S 381.4
USP Celecoxib Related Compound B RS
4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
C17H14F3N3O2S 381.4
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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| Fa'ailoga Mata'utia | Xn - Fa'aleagaina |
| Tulaga lamatia | R20/21/22 - E afaina pe a manava, pe a pa'u ma pe a folo. |
| R52 - E afaina i meaola o le vai | |
| R61 - E ono afaina ai le pepe e le'i fanau mai | |
| R60 - E ono fa'aleagaina ai le fausiaina | |
| Fa'amatalaga Saogalemu | S22 - Aua le manava pefu. |
| S24/25 - Aloese mai le pa'i i le pa'u ma mata. | |
| S28 - A uma ona pa'i i le pa'u, fufulu vave i le tele o fasimoli. | |
| S37/39 - Fai totigilima talafeagai ma mata/mata puipui | |
| UN ID | UN 3077 9 / PGIII |
| WGK Siamani | 3 |
| RTECS | DB2944937 |
| HS Code | 2935900090 |
| Vasega o Tulaga Lamatia | FAAFITAU |
Celecoxib ma Rofecoxib o loʻo faʻaaogaina nei COX-2 inhibitors.Fa'amanuiaina le atina'eina e le GD Searle & Pfizer Co. (US,) fa'asalalau i le 1999, igoa tau fefa'ataua'iga: Celebrex.Celecoxib ose nonsteroidal, anti-inflammatory agent faʻatasi ai ma analgesic taua ma faʻamaʻi faʻamaʻi, mafua ai le maualalo o aʻafiaga o le pito i luga ole gastrointestinal tract ma isi faʻalavelave.Fa'aoga ile falema'i e togafitia ai le oseoarthritis ma'i ma le fa'ama'i ma le gugu o le rheumatoid, fa'atasi ai ma se vaega e fa'amama ai fa'ama'i, fa'amama fa'ailoga ma fa'ailoga o le osteoarthritis ma le gugu o le rheumatoid.
Celecoxib (CAS: 169590-42-5), Mo le fesoasoani ma le puleaina o le osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, tiga ogaoga, dysmenorrhea muamua ma le tuʻu faʻatasi i tausiga masani mo tagata mamaʻi. faʻatasi ma le polyposis adenomatous aiga.
Celecoxib (CAS: 169590-42-5) o loʻo i ai le faʻamaʻi faʻamaʻi ma le faʻamalolo o NSAID.Ona o lona fausaga vailaʻau, e mafai ona tuʻufaʻatasia ma COX-2, filifili faʻalavelave COX-2.O lona vaega phenyl e fusifusia ma le hydrophobic channel o COX-2, ma o lona hydrophilic sulfonamide e fausia ai se filifili hydrogen ma le 513 arginine ma le 90 histidine i le COX-2 " taga itu."E fesoʻotaʻi foʻi ma le arginine i le tulaga COX-2120 ma e iai sona sao i le taofia o le COX-2 mai le faʻaliliuina o le arachidonic acid i prostaglandins e afaina ai le tino o le tagata. -2, Celecoxib e le mafai ona ulufale i le COX-1 mole, pe faʻalavelaveina lona suiga o le arachidonic acid i prostaglandins. O lea, e iai aʻafiaga lelei faʻamaʻi ma analgesic, puipuia mucosa gastric, puipuia le tafe toto toto, faʻatonutonu platelet aggregation, ma foia le fa'afitauli fa'aleagaina ole manava ole NSAID e masani ona fa'aogaina.
Celecoxib (CAS: 169590-42-5) o loʻo faʻaalia mo le togafitia o le osteoarthritis ma le gasegase oona.O lona fa'aogaina e fa'asaina i tagata ta'ito'atasi e maua i le hypersensitivity i sulfonamides po'o isi NSAIDs.E tatau ona fa'aogaina ma le fa'aeteete i tagata e maua i fa'ama'i ate.Fegalegaleaiga e tupu ma isi vailaʻau e faʻaosoina ai le CYP2C9 (eg rifampin rifampin) pe tauva mo metabolism e lenei enzyme (eg fluconazole, leflunomide).O a'afiaga sili ona taatele ile celecoxib ole a'afiaga ole GI ile laititi e pei ole dyspepsia, manava manava, ma le tiga ole manava.E seasea tupu ni a'afiaga ogaoga o le GI ma le fatu.
