Crizotinib CAS 877399-52-5 Su'ega ≥99.0% API Falegaosi Tulaga Maualuga
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Crizotinib (CAS: 877399-52-5) faʻatasi ai ma tulaga maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Crizotinib,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Crizotinib |
| Synonyms | Xalkori;PF-02341066;Crozotinib;Crizotinib Xalkori;3-[1-(2,6-Dichloro-3-Fluoro-phenyl)-ethoxy]-5-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine;(R)-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]-5-(1-Piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine |
| Numera CAS | 877399-52-5 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C21H22Cl2FN5O |
| Molecular Weight | 450.34 |
| Lisi Lisi | 192℃ |
| Malosi | 1.47±0.10g/cm3 |
| Teuga vevela | Temperature Potu |
| Amataga | Shanghai, Saina |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e |
| Fa'ailoaga | Saunia e IR, HPLC |
| Malamalama ole Fofo | Fa'atatau ile Fa'atonu |
| Ma'imau ile Fa'amago | ≤1.00% |
| Toega i luga o le mumu | ≤0.50% |
| Fa'aleaga Fa'atatau | (e le HPLC) |
| Le mama nofofua | ≤0.50% |
| Aofa'i Fa'aleaga | ≤1.00% |
| Metala mamafa | ≤20ppm |
| Su'ega | ≥99.0% |
| Solvents totoe | Faʻafeiloaʻi le Faʻamatalaga |
| Ola Fa'asa | 24 masina |
| Tulaga Su'ega | Pisinisi Tulaga |
afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Taofi mau le atigipusa ma teu i totonu o se faleteuoloa malulu, mago (2~8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.
Fa'amatalaga Saogalemu 24/25 - Aloese mai le pa'i i le pa'u ma mata.
UN ID UN 3077 9 / PGIII
WGK Siamani 3
HS Code 2933990099
Vasega o Tulaga Lamatia
Crizotinib (CAS 877399-52-5), (Crizotinib, Xalkori R), o se ATP faʻatauvaʻa faʻatauvaʻa laʻititi laʻititi o le ALK ma le c-Met.I le masina o Aukuso 2011, na faamaonia ai e le FDA a le Iunaite Setete le Crizotinib mo le togafitia o anaplastic lymphoma kinase (ALK) toe faatulaga le kanesa o le mama e le o ni sela laiti (NSCLC).Crizotinib o se fa'atauva'a fa'atauva'a ATP lua o tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) ma le ALK (cellular IC50 = 20 nM), o ia mea uma e lua o sini taua mo le kanesa chemotherapy.Ina ua tofotofoina le crizotinib mo le filifilia ma isi kinases na maua ai le enzyme IC50's i totonu ole 100-fold multiples o c-MET mo le 13 o le 120 kinases na tofotofoina.I suʻesuʻega feaveaʻi, na maua ai le crizotinib e taofia le RON (recepteur d'origine nantais) kinase faʻatasi ai ma le 10-fold selectivity window i luga ole c-MET.
Crizotinib (PF-02341066) Crizotinib o se malosi c-Met ma ALK inhibitor, o le IC50 tau i le suʻega cell e 11 nM ma 24 nM, faasologa.O se fa'alavelave malosi fo'i o le ROS1 fa'atasi ai ma le tau Ki e itiiti ifo i le 0.025 nM.Crizotinib e mafai ona faʻaosoina le autophagy i le tele o laina sela o le kanesa o le mama e ala i le taofiofia o le ala STAT3.
O le Crizotinib o se fa'atosina malosi ma le filifilia o le mesenchymal-epithelial transition factor (c-MET) kinase ma anaplastic lymphoma kinase (ALK).Crizotinib o se vailaʻau faʻamaʻi faʻamaʻi.I le masina o Aokuso 2011, na faʻamaonia ai e le FDA a le Iunaite Setete le crizotinib mo le togafitia o anaplastic lymphoma kinase (ALK) toe faʻatulagaina le kanesa o le mama e le o ni sela laiti (NSCLC).
Crizotinib (Xalkori (R), Pfizer), faʻamaonia i le 2011, o le faʻatagaina muamua faʻamaonia e faʻatatau i anaplastic lymphoma kinase (ALK).ROS protooncogene 1-encoded kinase (ROS1) o le tyrosine kinase insulin receptor class ma le MET proto-oncogene-encoded kinase o le hepatocyte growth factor receptor (HGFR) vasega o isi kinases na faʻatatau e crizotinib. Ina ua faʻamaonia i le 2011, o le crizotinib o le muamua. vaila'au fa'apitoa e fa'atatau i gasegase NSCLC.Ae ui i lea, o le tetee atu i le crizotinib e masani lava ona matauina pe a ma le 8 masina talu ona maeʻa le faʻaoga muamua ma sili atu ma le afa o tagata gasegase na togafitia i le crizotinib na aʻafia i aʻafiaga o le manava.I le 2016, crizotinib na faʻamaonia atili mo le ROS1-positive NSCLC e le FDA.
O le Crizotinib (Xalkori) o se fa'agata ole tyrosine kinase e fa'ailoa mo le togafitia o tagata mama'i e maua i le kanesa o le mama mama (NSCLC).O aʻafiaga masani ile faʻaaogaina o le Xalkori e aofia ai faʻamaʻi pito i luga ole manava, faufau, puaʻi, tiga o le manava, faʻaitiitia le manaʻo, le mautonu, niniva, lagona vaivai, manava manava, mageso poʻo le mageso, faʻaʻailoga malulu (mafu isu, mafatua, tiga le faʻaʻi), faʻalogo poʻo tingling, po'o le fula i ou lima po'o vae.
