Hydroxypropyl-β-Cyclodextrin CAS 128446-35-5 (HP-β-CD) Mea Fa'aaogā Fa'afoma'i
Ruifu Chemical o le taʻutaʻua taʻutaʻua o le Hydroxypropyl-β-Cyclodextrin (HPBCD; HP-β-CD) (CAS: 128446-35-5) faʻatasi ai ma le maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Hydroxypropyl-β-Cyclodextrin,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Hydroxypropyl-β-Cyclodextrin |
| Synonyms | Cyclodextrin HPB;Hydroxypropyl-Beta-Cyclodextrin;(2-Hydroxypropyl)-β-Cyclodextrin;(2-Hydroxypropyl)-beta-Cyclodextrin;beta-Hydroxypropylcyclodextrin;HBC;HPBCD;HP-β-CD |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 128446-35-5 |
| Fuafua mole | C63H112O42 |
| Molecular Weight | 1541.54 g/mol |
| Lisi Lisi | 262.0~269.0 ℃ |
| Malosi | 1.05 |
| Ta'amilosaga Fa'apitoa [a]20/D | +120° i le +135° (C=1, H2O) |
| Suavai Solubility | Solu i le Vai |
| COA & MSDS | Avanoa |
| Fa'ata'ita'iga Sa'oloto | Avanoa |
| Amataga | Shanghai, Saina |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga | I'uga |
| Fa'aaliga | Pa'epa'e Pa'epa'e, Insipid, Taumama | Fa'atatau |
| IR Alaleo | Fa'a'au'au Fa'asa'o tutusa ma USP Hydroxypropyl Betadex RS | Fa'atatau |
| pH | 5.0~7.5 | 6.57 |
| Malamalama ole Fofo | Fofo manino ma le lanu | Fa'atatau |
| Ma'imau ile Fa'amago | ≤10.0% | 3.5% |
| Toega i luga o le mumu | ≤0.20% | 0.09% |
| Metala mamafa | ≤20ppm | <10ppm |
| Klorida | ≤0.05% | <0.05% |
| Suiga Molar | 0.4~1.5 | 0.63 |
| Conductivity | 10% (w/v) Suavai Fofo ≤200μS/cm | 154µS/cm |
| Tulaga o Suiga | 2.8~10.5 | 5.3 |
| Toega Betadex | ≤1.50% | 0.12% |
| Propylene Glycol | ≤2.50% | 0.29% |
| Propylene Oxide | ≤1ppm | <1ppm |
| So'o se isi mea le mama e tasi | ≤0.25% | <0.25% |
| Aofa'iga o Isi Fa'aleaga | ≤1.00% (E le aofia ai Betadex ma Propylen Glycol) | 0.51% |
| TAMC | ≤1000cfu/g | 30cfu/g |
| TYMC | ≤100cfu/g | 10cfu/g |
| Escherichia Coli | E le mafai ona iloa | Fa'atatau |
| Salmonella | Toesea | Toesea |
| Endotoxins siama | <10IU/g | <10IU/g |
| Fa'ai'uga | Fa'ata'ita'i ma Usita'ia le Fa'atonu USP35 | |
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| WGK Siamani | 3 |
| RTECS | GU2293332 |
| HS Code | 3505100000 |
Hydroxypropyl-β-Cyclodextrin (HPBCD; HP-β-CD) (CAS: 128446-35-5) o se cyclodextrin faʻaaogaina lautele faʻaaogaina, o le lipophilic cavity na fausia e 7 glucose units.Ole solubility ole vaila'au ile vai e matua fa'aleleia e ala ile lavelave ile HP-β-CD.Lafoa'i fa'a'au'au, fa'aola fa'atutusa, tu'uina atu vaila'au fa'ama'i buccal ma transdermal.
O le Hydroxypropyl-β-Cyclodextrin, o le hydroxyalkyl derivative, e maua ai le faʻaogaina o se taʻavale faʻapipiʻi e faʻaaogaina e faʻaleleia ai le solubility o vailaʻau i vaifofo vai mo le tuʻuina atu manuia o vailaʻau faʻafomaʻi i faiga faʻaola.E masani ona faʻaaogaina e fai ma sui mo α-, β- ma γ-Cyclodextrins.
O le hydroxypropyl betadex sa su'esu'eina lautele i vaila'au ma ua fa'aaogaina e fai ma solubilizer mo mole mole o le hydrophobic i totonu o le gutu vai, oral solids, parenterals, pressured metered dose inhalers, dry powder inhalers, ma topical formulations.Ua faʻaalia foi e galue o se faʻamautu i le taimi o le gaosiga ma le teuina o mea faʻapipiʻi.Hydroxypropyl betadex inclusion complexes ua lipotia mai e faʻaalia ai mea faʻainisinia e ese mai mea mama.O le lelei ua lipotia mai o le hydroxypropyl betadex nai lo le b-cyclodextrin e le'i suia o lona sili atu lea o le solubility i le vai.
1. Solubilization ma solubilization, faia insoluble vailaʻau faʻamavaeina, faʻaleleia le solubility o vaega malosi o vailaʻau suauʻu, tuʻuina atu fualaau faʻatau ma puipuia le aoga o vailaʻau.
2. Faʻaleleia le bioavailability o le vailaʻau, faʻateleina le togafitiga o le vailaʻau poʻo le faʻaitiitia o le vailaʻau.
3. Fetuuna'i pe pulea le fua faatatau o fualaau faasaina e faaitiitia ai aafiaga itu.
4. Ufiufi le manogi leaga.
1) I totonu o fale talavai,
1. Hydroxypropyl Beta Cyclodextrin e mafai ona faʻateleina le solubility o vailaʻau ma meaola olaola, faʻaopoopoina le lelei lelei ma faʻaitiitia le fua.
2. E mafai e le HP-β-CD ona pulea pe fetuutuunai le saoasaoa o le gaioiga, faʻaititia le vailaʻau oona ma faʻaleleia le mautu o vailaʻau.
3. O se mea e fa'afefeteina tui lelei ma vaila'au fa'apitoa ona o le fa'aogaina o le tino ma le fa'aogaina o le hemolytic, e leai se fa'alavelave maso.
4. HP-β-CD e le gata e faʻaaogaina i vailaʻau faʻamalosi, tui, mucosal drug delivery system, transdermal drug delivery system, lipotropy targeting drug carrier, ae mafai foi ona faʻaaogaina e avea ma sui o le puipuiga o le protein ma le stabilizer.
5. Faʻaleleia mea faʻapitoa o mea oona pe le lelei.
2) I le fanua taumafa,
1. E mafai e le HP-β-CD ona puipuia le fa'asao o mea fa'afefeteina o lo'o tausia le mautu o ana mea'ai, fa'ate'a ese le manogi mata'utia ma e mafai ona fa'aleleia atili ai a'afiaga o le emulsification ma le fa'aogaina tu'ufa'atasi o mea'ai emulsifiers.
2. E mafai fo'i e le HP-β-CD ona fa'asao le fa'asa'olotoina o mea'ai, fa'atupuina le a'afiaga o le fa'a'ele'ele ma fa'alautele le fa'aola o mea'ai.
3) I Alamanuia Fa'atauga
1. I totonu o mea teuteu mata e faʻaaogaina e pei o le stabilizer, emulsifier, solubilizer ma isi.
2. HP-β-CD e mafai ona faʻaitiitia le faʻamalosi i le paʻu, ma faʻaleleia le mautu o vaega aoga
3. E mafai e le HP-β-CD ona fa'aitiitia pe ufiufi le manogi leaga o mea'ai mole mole.
4. Puipuia le tuufaatasiga o meaʻai o le volatile, oxidation, faateleina le infusibility, essence, manogi vai-soluble ma Taofi le manogi lemu tatalaina ma tumau.
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