Darunavir CAS 206361-99-1 Anti-HIV Purity ≥99.0% API High Purity HIV Protease Inhibitor
Sapalai a le KamupaniDarunavir Oloa Fa'atatau:
Darunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
| Igoa Vailaau | Darunavir |
| Synonyms | TMC114;UIC-94017 |
| Numera CAS | 206361-99-1 |
| CAT Numera | RF-API68 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C27H37N3O7S |
| Molecular Weight | 547.66 |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'u Pa'epa'e po'o le Pa'epa'e Pa'epa'e |
| Fa'ailoaga | MS/HNMR HPLC |
| Solubility | Solu i le DMSO, solu teisi i le vai |
| Lisi Lisi | 74.0~76.0 ℃ |
| Fa'ailoaga | 1H NMR |
| Mama / Suʻesuʻega Metotia | ≥99.0% (HPLC) |
| Mea Fa'atatau | |
| Max nofofua le mama | ≤0.30% |
| Aofa'i Fa'aleaga | ≤1.0% |
| Solvents totoe | Ethanol ≤0.30% |
| Ma'imau ile Fa'amago | ≤0.50% |
| Toega i luga o le mumu | ≤0.10% |
| Metala mamafa | ≤20ppm |
| Arsenic | ≤1.5ppm |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | Darunavir (CAS 206361-99-1) HIV-1 Protease Inhibitor Anti-HIV |
afifi: Fagu, Ato pepa alumini, Pusa Pusa, 25kg / Paʻu, poʻo e tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Darunavir (igoa fa'ailoga Prezista, sa ta'ua muamua o le TMC114) o se vaila'au fa'asaina o le protease e fa'aaogaina e togafitia ai fa'ama'i pipisi o le HIV.Darunavir o se OARAC fautuaina togafitiga filifiliga mo togafitiga-naive ma togafitiga-aafiaga matutua ma talavou.Darunavir ose ituaiga fou ole non peptide anti retroviral protease inhibitors ile AIDS togafitiga.E muamua fausia e le Johnson pharmaceutical Iceland lala, Tibotec.E sili ona maualuga le bioavailability i le 6 protease inhibitors (saquinavir, ritonavirvir, indinavir, naphthalene nelfinavir, amprenavir ma ABT378/r).E galue e ala i le taofia o le fausiaina o siama fou ma matutua mai luga o sela o loʻo aʻafia ma taofia ai le protease a le siama.A faʻaaogaina le oloa mo se taimi umi, e masani lava e mafai ona faʻaitiitia le siama HIV i totonu o le toto, faʻateleina le numera o sela CD4, faʻaitiitia le avanoa e maua ai le HIV, faʻaleleia le lelei o le olaga ma faʻaumiumi le ola.E talafeagai mo tagata matutua o loʻo aʻafia i le HIV ae leai se aafiaga i le faʻaaogaina o vailaʻau faʻamaʻi o loʻo iai.O le vailaʻau e tatau ona tuʻufaʻatasia ma le faʻaogaina o tui maualalo o ritonavir poʻo isi vailaʻau antiretroviral, ina ia faʻaleleia ai le aoga.E mafai ona su'esu'eina le gaioiga fa'ama'i i vitro e ala i le fa'asagatau atu i lymphocytes ma'i fa'ama'i pipisi ma lymphocytes ile toto pito.
