Darunavir Ethanolate CAS 635728-49-3 Mama ≥99.0% API Falegaosi Anti-HIV HIV Fa'asa'o
Faumea Faumea Sapalai Darunavir Oloa Fa'atatau:
Darunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
| Igoa Vailaau | Darunavir Ethanolate |
| Synonyms | DRV;Prezista;TMC114 Ethanolate;UNII-33O78XF0BW;N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl ester compd.ma le ethanol |
| Numera CAS | 635728-49-3 |
| CAT Numera | RF-API69 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C29H43N3O8S |
| Molecular Weight | 593.73 |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'u Pa'epa'e po'o le Pa'epa'e Pa'epa'e |
| Faailoaina IR | E fetaui ma le Alaleo Fa'ata'atia |
| Ta'amilosaga Fa'apitoa | -0.5°~ +0.5° |
| Mea Fa'atatau | (e le HPLC) |
| Max nofofua le mama | ≤0.20% |
| Aofa'i Fa'aleaga | ≤0.50% |
| Vai (KF) | ≤1.0% |
| Toega i luga o le mumu | ≤0.10% |
| Metala mamafa | ≤10ppm |
| Aano o le Ethanol | ≤7.5% (GC) |
| Solvents totoe | Methanol ≤0.30% |
| Mama | ≥99.0% (HPLC) |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
afifi: Fagu, Ato pepa alumini, Pusa Pusa, 25kg / Paʻu, poʻo e tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
O le Darunavir Ethanolate (Prezista) o se fa'ama'i protease HIV.Fa'atupuina o Darunavir, o le fa'atupuina lona lua o le HIV-1-protease inhibitor;faʻatulagaina tutusa ma amprenavir.Antiviral.Ose oloa su'esu'e fa'atatau ile COVID19.O le mea e leaga ai, o le DRV e maualalo le soluble i le vai ma le le lelei o le bioavailability, o lea e manaʻomia ai le faʻatonuina i ni tui maualuga ina ia faʻaalia ai le aoga o togafitiga.O le Darunavir o se fa'atosina malosi o alaleo lautele o lo'o galue e fa'asaga i fa'ama'i fa'ama'i HIV-1 ma e la'ititi le cytotoxicity.O le Darunavir e fa'atūina fa'amauga o le hydrogen fa'atasi ai ma le fa'apolopolo o filifili autu o le Asp29 ma le Asp30 o le protease.O nei feso'ota'iga e fa'atatau e taua tele mo le malosi o lenei fa'aputuga e fa'asaga i fa'ama'i fa'ama'i fa'ama'i HIV e fa'asa'o i le tele o fa'ainisinia protease.I se suʻesuʻega in vitro i sela MT-2, o le malosi o le darunavir e sili atu nai lo le saquinavir, amprenavir, nelfinavir, indinavir, lopinavir ma ritonavir.O le Darunavir o loʻo faʻaaogaina muamua e le enzymes cytochrome P450 (CYP) ate, aemaise lava CYP3A.Ole fua ole ritonavir ole 'fa'aosoina' e fai ma se inhibitor ole CYP3A, ma fa'ateleina ai le bioavailability o le darunavir.Darunavir na mamanuina e fausia ni fegalegaleaiga malosi ma le enzyme protease mai le tele o aʻafiaga o le HIV, e aofia ai maʻi mai togafitiga-aʻafia tagata gasegase ma le tele o mutati tetee.
