Decitabine CAS 2353-33-5 Mama >99.5% (HPLC) Falegaosimea
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma faʻatau atu le Decitabine (CAS: 2353-33-5) faʻatasi ai ma le maualuga.E mafai ona matou tuʻuina atu COA, faʻasalalauga i le lalolagi atoa, laʻititi ma le tele o loʻo avanoa.Afai e te fiafia i lenei oloa, faʻamolemole lafo mai faʻamatalaga auʻiliʻili e aofia ai numera CAS, igoa o oloa, aofaʻi ia i matou.Please contact: alvin@ruifuchem.com
Igoa Vailaau | Decitabine |
Synonyms | 5-Aza-2'-Deoxycytidine;5-Aza-1-(2-Deoxy-β-D-Ribofuranosyl)cytosine;5-Aza-CdR;5-Aza-dC;5-Deoxy-2'-Azacytidine;ZdCyd;DAC;β-Decitabine |
Numera CAS | 2353-33-5 |
CAT Numera | RF2728 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C8H12N4O4 |
Molecular Weight | 228.21 |
Lisi Lisi | 191℃(Tes.) |
Ma'ale'ale | Ma'ale'ale ea, Ma'ale'ale vevela |
Solubility | Fa'amavae ile DMSO;Laititi Solu i le Vai |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'u Pa'epa'e po'o le Pa'epa'e Pa'epa'e |
Faailoaina A | IR: Fa'ata'ita'iga IR Spectrum e fetaui ma le tulaga o le Standard |
Faailoaga B | HPLC: O le RT o le Tulaga Tele o le Su'ega Su'ega E fetaui ma lena o le Fofo masani |
Faailoaina C | PXRD: Lelei |
Mama / Suʻesuʻega Metotia | >99.5% (HPLC) |
Alefa | +56.0°~ 63.0° |
Ma'imau ile Fa'amago | <0.50% |
Toega i luga o le mumu | <0.10% |
Metala mamafa | <20ppm |
Mea Fa'atatau | |
α-Decitabine | <0.20% |
Nofofua Le iloa le mama | <0.20% |
Aofa'i Fa'aleaga | <0.50% |
Solvents totoe | |
DMSO | <0.50% |
Methanol | <0.30% |
Methyl Formate | <0.05% |
Acetonitrile | <0.041% |
Solubility | E leai ni lanu manino 50 mg/ml, HOAc ma le H2O (1:1) Pas |
Tulaga Su'ega | Pisinisi Tulaga |
afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu
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Decitabine (CAS: 2353-33-5) (igoa fefaʻatauaʻiga Dacogen), poʻo le 5-Aza-2'-Deoxycytidine.I le vailaʻau, o le cytidine analog.Decitabine o se vailaʻau hypomethylating.Decitabine ua faʻalauiloaina mo togafitiga o faʻamaʻi o le myelodysplastic (MDS).MDS o se seti o faʻafitauli hematologic e aʻafia ai le gaʻo ponaivi e mafua ai le le lelei o le fausiaina ma le atinaʻeina o sela toto.E le gata i lea, o tagata gasegase e maua i le MDS e maualuga le lamatiaga o le alualu i luma i le maʻi leukemia myeloid (AML).O togafitiga fa'aleaganu'u e aofia ai le tu'uina atu o le toto, fa'atupuina o le hematopoietic, ma fa'ama'i fa'ama'i, ae o nei faiga e na'o le fa'aleleia atili o le olaga ma ni a'afiaga e fesiligia i suiga o fa'ama'i.E ui o le fa'atupuina o le stem-cell o se faiga fa'amalosi, e mafai ona togafitia, o le matua po'o isi fa'afitauli fa'alesoifua maloloina o le tele o gasegase e taofia ai i latou mai le iloiloina o lenei filifiliga.O le alualu i luma talu ai nei i le mafuaʻaga autu o le MDS, peitaʻi, ua taʻitaʻia ai le atinaʻeina o se vasega fou o mea faʻapipiʻi ua taʻua o le 'demethylating agents'.Decitabine mulimuli i le faʻalauiloaina manuia o le DNA methyltransferase inhibitor muamua Azacitidine.E hypomethylates DNA e ala i le taofia o le DNA methyltransferase.E galue i se faiga tutusa i le Azacitidine, e ui lava e naʻo le decitabine e mafai ona tuʻufaʻatasia i le DNA strands ae o le azacitidine e mafai ona tuʻufaʻatasia i le DNA ma le RNA filifili.Reagents su'esu'e: Decitabine e fa'aaogaina lautele i le molecular biology, pharmacology, ma isi su'esu'ega faasaienisi.Decitabine ose DNA methyltransferase inhibitor fa'apitoa, toe fa'afo'i le DNA methylation process, fa'aosoina sela tumo i sela masani e fa'aeseese pe fa'aoso apoptosis cell tumo.Fa'amolemole maitau o le maualuga o le fa'atonuga o le Decitabine o le a fa'aalia ai lona aafiaga cytotoxic: e mafai ona fa'alavelaveina le fa'aogaina o le DNA fa'aosoina le oti sela.