DMF-DMA CAS 4637-24-5 N,N-Dimethylformamide Dimethyl Acetal Purity>99.0% (GC) Fale Fa'atauga vevela

Talu ai na lipotia e Meenvin le sauniuniga o le DMF-DMA (N, N-Dimethylformamide Dimethyl Acetal) i le 1956, ua avea le DMF-DMA ma se reagent e masani ona faʻaaogaina i le faʻaogaina o meaola.
DMF-DMA o loʻo faʻaaogaina lautele i le fausiaina o mama heterocyclic e lima pe ono i totonu ole tali tapuni.O le DMF-DMA o loʻo i ai le tali malie ma le maualuga o fua, aemaise lava mo faʻalavelave maualuga.
O le fausaga lautele o amide acetal compound e faʻapea:
O le faʻaaogaina lautele o le DMF-DMA ma le DMF-DEA, o le amide acetal e faigofie ona faʻafefeteina, e mafai ona esterified, amidine, alkylation ma cyclization reactions.
O le ogatotonu o le carbon atom o DMF-DMA e fesoʻotaʻi ma tolu heteroatoms ma tele electronegative, lea e maua ai le malosi eletise eletise.I lalo o le gaioiga o le acid, e faigofie ona alu le vaega alkoxy, ma maua ai ni ion lelei ma le malosi eletise eletise.O le tali a le DMF-DMA e masani lava ona aofia ai le tali atu o le methylation ma le faʻatulagaina o gaioiga.
"One-carbon Syntheson" o le DMF-DMA
I le tali tapuni tapuni e aofia ai le DMF-DMA, e na'o le tasi le carbon atom i totonu o le oloa e masani ona saunia e DMF-DMA, o lea e mafai ai ona manatu DMF-DMA o se carbon syntheson.
DMF-DMA esterification tali
DMF-DMA esterification e mafai ai e vaila'au carboxylic eseese e fa'afaigofie ona fa'atupuina le C1-20 alkyl po'o le aril esters, ma e mafai ona faigofie ona tu'u'ese'ese mea e maua mai i le fa'amama.
Adipic acid ma DMF-DMA na faʻasalaina ile 80 tikeri mo le lua itula.Amide acetal o se filifiliga lelei mo esterification o nisi carboxylic acids ma steric aindrance poʻo le mautu lelei.
Tali a DMF-DMA amidination ma le puipuiga o amine muamua
Amide acetals e mafai ona tali atu e le gata i amine muamua, ae faʻapea foʻi ma amides, carbamates, sulfonamides e fausia ai fusi hydrocarbon.
E pei o: 2, 4-dimethyl aniline ma DMF-DMA i 80 tikeri e mafai ona vave aveese le methanol e fausia ai le dimethamidine compounds.
DMF-DMA e mafai foi ona faʻaaogaina e avea o se vaega puipuia amine muamua, vaega puipuia amine muamua (2 NH puipuiga uma) atonu o le toʻatele o tagata e mafaufau i le phthalyl, pyrrole ring, double Boc, double PMB, ma isi, ae o le DMF-DMA puipuiga o le tulaga muamua. amine, i nisi tulaga e aoga tele foi polokalame puipuiga, ese le puipuiga e manaomia TFA se fefiloi.
Puipuiga amino - 13 fa'avae puipuiga masani fa'atomuaga, puipuiga fa'avae filifiliga filifiliga, fa'aogaina o fa'aoga, tulaga fa'atomuaga, tu'u'ese'ese tulaga fa'asoa aotelega
O le DMF-DMA e tali atu i vaega methyl ma methylene malosi e fausia ai fusi lua carbon-carbon
Phenylmethylation o DMF-DMA
O fa'a'avega fa'atasi i le DMF-DMA
Amide acetal e pei o se kaponi foa'i e tasi e mafai ona fa'aogaina e fa'apipi'i ai fa'alavelave lavelave eseese ma mea fa'anatura fa'aola.Faatasi ai ma amide acetals e mafai ona faʻapipiʻiina: 1,2.4 triazole, 1.2, 4 triazolone, aminoheterocyclic derivatives, pyrimidine, pyrimidine, indoles, pyridine, quinoline, thiazole, oxazolone, isooxazole, 1.2, 4-triazone, pyranone, pyranone. o ammonia heterocyclic derivatives, e mafai foi ona synthesized okesene, sulfur heterocyclic tuufaatasiga.
E tusa ai ma le ituaiga o vailaʻau faʻasolosolo, o le faʻaaogaina o le amide acetal i le heterocyclic compound synthesis e mafai ona vaevaeina i vaega nei e tolu.
(1): amide acetal ma amine, amide, carbamate lipid reaction, faʻatupuina le tele o mama heterocyclic
Amidoacetal ma amine tali i formamidine intermediate, ona intramolecular nucleophilic mama tali e faatupuina ai heterocycles eseese, po o le formamidine ma hydrazine, hydroxylamine, l, 2, tasi pe lua alkyl halides o loʻo i ai vaega malosi e lua o tuufaatasiga ma filifili umi carbon, ona mama intramolecular. .
Fa'atupuina o fa'atasiga o le heterocyclic e ala i le tali atu o acetals amide ma amides, e pei o le fa'aogaina o le l, 2,4 monotriazole derivatives.Muamua, o le acetal e tali atu i le amide e fausia ai le N, N 'tritradil, ona tatagi lea i le phenylhydrazine e fausia ai le l, 2,4 monotriazole derivatives.
Amide acetals e tali atu i le carbamic acid poʻo le acetate e fai ai mama heterocyclic o loʻo iai chlorine.O se mea fa'a-diactive e fa'atupuina e ala i le tali atu o se amide acetal ma se aminoethyl ester: nn-dimethyl-n 'alkyl-carboxymethyl formamidine, lea e tali atu i le hydrazine po'o le hydrazine sui.Mo se faʻataʻitaʻiga, mo le sauniuniga o le 1,2,4 triazinone-6, o loʻo faʻaalia i lalo le faʻatusatusaga.Afai e te tali atu i se nitro-formate e te maua le 1,2,4 triazolone-5.
Faʻamatalaga faʻaogaina mo le faʻavaeina o le 1,2,4 triazolone-5
O le tuufaatasiga o le 1.2.4-triazolidin-5 e lua laasaga.Muamua, o le ethyl carbamate ma le DMF diformaldehyde acetals e fausia ai le Nn-dimethyl-n-ethoxy-formamidine.Lona lua, o le vaega amino i luga o le phenylhydrazine e faʻaumatia le carbon i luga o le formamidine, lea e leiloa -N (CH3).Ona osofaia lea e le ammonia i luga o le mama benzene latalata i le phenylhydrazine le carbon i luga o le carbon group, e fausia ai se anion okesene, ma o le paʻu tasi o electrons i luga o le okesene e sau i lalo, leiloa le vaega ethoxy, ma maua ai le 1.2, 4-triazolone-5.
(II) Sauniuniga o vailaʻau heterocyclic e ala ile tali ole amide acetal ma le amide
Ole auala pito sili lea ona lipotia ole fa'aogaina ole le mama ile sefulu tausaga talu ai.O le gaioiga o le amide acetal e tutusa ma le Grignard reagent, ae o le tali o le amide acetal e faigofie ma agamalu.
Amide acetal e lua vaega toaaga, maualuga reactivity, ma methyl malosi, tali methylene e fausia ai le amidine intermediates, e mafai ona toe tali atu, mama tapunia, ma Grignard reagent ma methylene tali, na o le umi o le filifili carbon, e le mafai ona toe tali atu.Mo se faʻataʻitaʻiga, tuʻufaʻatasiga o mea e maua mai i le furanochroone.
(3): amide acetal ma hydroxyl, sulfhydryl fa'atupu fa'atupuina o le okesene, sulfur heterocyclic compound
O le faʻasologa o loʻo i luga o le furohutanone o se faʻataʻitaʻiga lelei o le acetal generation of enamine derivatives ma hydroxyl group e ala i le vavaeeseina o le pou endolateral, e mafua ai le oxy-containing heteramine:.O le isi fa'ata'ita'iga: catechol ma le DMF -- DMA e fai mama o le okesene pe a iai le dichloromethane.
Ole tali ole DMF -- DMA ma le o-mercaptoaniline e mafai ona maua ai le sulfur-containing heterocyclic mama, o le fua faʻatatau e faʻapea.
Tulaga su'esu'ega ole tali tapunia ole mama DMF-DMA ma tali a le tagata lava ia
(1) Batcho-Leimgruber indole synthesis
Saunia o vailaʻau eseese Vindol mai le o-nitrotoluene.
Faiga fa'afoliga
Muamua lava, o le dimethylformamide dimethylacetal, o ion le lelei o le vaega methoxy o loʻo tuʻuina atu e maua ai se mea e sili atu ona faʻaalia.E osofaia e carboanions e faia e le deprotonation o le o-nitrotoluene methyl hydrogen ma leiloa le methanol e maua ai le enylamine ua taua i luga.O le oloa o lenei laasaga, enamine, e pei o se alkene ma eletonika-aveeseina ma electron-doning substituents faapipii i itu uma e lua (Push-toso olefin e malosi polar ma e masani ona pogisa mumu ona o le tele conjugation laina i le mole. I le laasaga lona lua o le tali, o le vaega nitro ua faʻaitiitia i se vaega amino, sosoo ai ma le cyclization ma le faʻaumatia e maua ai le oloa mulimuli.
(2) Ata tu'ufa'atasi o mea e maua mai i le pyridine
(3) Fa'asologa o mea e maua mai i le pyrazole