Doxorubicin Hydrochloride CAS 25316-40-9 API USP Fa'ata'ita'iga Falegaosi Ma'a Maualuga
Faumea e maualuga le mama ma mautu lelei
Igoa vaila'au: Doxorubicin Hydrochloride
CAS: 25316-40-9
Antitumor Antibiotic Agent.Taofi le DNA Topoisomerase II
API Tulaga Maualuga, Gaosiga Fa'apisinisi
Igoa Vailaau | Doxorubicin Hydrochloride |
Synonyms | Doxorubicin HCl;Adriamycin HCL;Hydroxydaunorubicin Hydrochloride |
Numera CAS | 25316-40-9 |
CAT Numera | RF-API38 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C27H30ClNO11 |
Molecular Weight | 579.98 |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Lanumu-Mula po'o le Pa'u tioata mumu;Leai se fa'amaoniga vaaia o le fa'aleagaina e mea mai fafo |
Solubility | Solu i le vai ma le methanol;solu teisi i le ethanol;e le mafai ona solu i le acetone |
Faailoaina A | Ole fusi ole IR e fetaui ma le fusi ole IR ole tulaga fa'asino |
Faailoaga B | O le taimi o le taofiga o le maualuga o le doxorubicin i le chromatogram o le sauniuniga Assay e fetaui ma lena i le chromatogram o le sauniuniga Tulaga, e pei ona maua i le Assay. |
pH | 4.0~5.5 |
Suavai Suavai | ≤4.0% |
Mea Fa'atatau | |
Le mama A (Doxorubicinol) | ≤0.50% |
So'o se isi mea leaga e le iloa | ≤0.20% |
Aofa'i Fa'aleaga Leiloa | ≤0.50% |
Aofa'i Fa'aleaga | ≤1.0% |
Su'ega | 98.0% ~ 102.0% o le C27H30ClNO11 fuafuaina i luga o le anhydrous, solu-saoloto faavae |
Solvents totoe | |
Acetone | ≤0.50% |
Acetone + Ethanol | ≤2.5% |
Methanol | ≤0.30% |
Dichloromethane | ≤0.06% |
Tulaga Su'ega | United States Pharmacopeia (USP) Reference Standard |
Fa'aoga | Mea Fa'afoma'i Gaoioiga (API) |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma tuʻuina atu le Doxorubicin Hydrochloride (CAS: 25316-40-9) faʻatasi ai ma le maualuga.Doxorubicin hydrochloride, o le cytotoxic anthracycline antibiotic, o se vailaʻau faʻamaʻi faʻamaʻi kanesa.Doxorubicin hydrochloride o se tagata malosi DNA topoisomerase I ma topoisomerase II inhibitor ma IC50s o 0.8 μM ma 2.67 μM, faasologa.Doxorubicin hydrochloride fa'aoso apoptosis ma autophagy.O le Doxorubicin ose vaila'au malosi e tetee atu ai i le tele o fa'ama'i leaga, e aofia ai le leukemia, sarcomas, kanesa o le susu, kanesa o le mama sela ma le kanesa ovarian.