Entecavir CAS 142217-69-4 API Falegaosi Mea Maualuluga Tulaga Anti-HBV
Tuuina atu a le Faumea ma le Mamalu Maualuga ma le Tulaga Lelei
Igoa Vailaau: Entecavir
CAS: 142217-69-4
Antiviral vailaʻau faʻaaogaina i le togafitiga o Faʻamaʻi Hepatitis B
API Tulaga Maualuga, Gaosiga Fa'apisinisi
Igoa Vailaau | Entecavir |
Synonyms | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one |
Numera CAS | 142217-69-4 |
CAT Numera | RF-API80 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
Fuafua mole | C12H15N5O3 |
Molecular Weight | 277.28 |
Lisi Lisi | 249.0~252.0 ℃ |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'u tioata Pa'epa'e |
Faailoaina IR | Ole alaleo ole absorption infraed ole fa'ata'ita'iga ole su'ega e tatau ona o gatasi ma tulaga fa'asino |
Fa'ailoga HPLC | O le taimi fa'atumauina o le fa'ata'ita'iga fa'ata'ita'iga e fetaui ma le tulaga fa'asino |
pH | 5.5~7.5 |
Fa'asinomaga Fa'ailo | +24.0°-+28.0° (DMF: MeOH=1:1 C=1%) |
Mea Fa'atatau | |
Aofa'i Fa'aleaga | ≤0.30% |
Avanoa Tasi Tumaoti | ≤0.10% |
Enantiomer | ≤0.20% |
Solvents totoe | |
Methanol | ≤0.30% |
Dichloromethane | ≤0.06% |
n-Hexane | ≤0.029% |
Tetrahydrofuran | ≤0.072% |
N,N-Dimethylformamide | ≤0.088% |
Toluene | ≤0.089% |
Suavai Suavai | 5.8%~6.5% |
Toega i luga o le mumu | ≤0.10% |
Metala mamafa | ≤20ppm |
Su'ega | 98.0%~102.0% (C12H15N5O3 fuafuaina i luga o le anhydrous faavae) |
Lapo'a La'au | D90: ≤100µm |
Tulaga Su'ega | Pisinisi Tulaga |
Fa'aoga | API, Antiviral vailaʻau faʻaaogaina i le togafitiga o Faʻamaʻi Hepatitis B |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Entecavir o se augatupulaga fou o le guanine nucleoside analogues oral vailaau mo togafitiga o le Hepatitis B Virus (HBV) faʻamaʻi, aemaise lava mo le togafitiga o tagata matutua maʻi ma viral replication gaoioiga ma serum transaminase faaauau pea ona faateleina, po o le ate aano mo gaoioiga pathological o hepatitis B tumau. , o lo'o i lalo ole virus ole sili ona vave ma sili ona malosi, ole fua fa'aliliuga pito i lalo ole nucleoside analogues.Faʻamatalaga faʻaalia e eseese i tagata mamaʻi ma hepatitis B faaumiumi, e aofia ai nucleoside naive ma nucleoside togafitia ma ate cirrhosis maʻi, faʻaaogaina lelei papa entecavir i le togafitiga e mafai ona pulea le faamaʻi vave ma faigofie ona oʻo atu i le togafitiga o le iuga moni, e pei o le hepatitis B virus unmeasured;e ala i le tausisia o togafitiga, o se vaega tele o gasegase e mafai ona taunuu i le faaiuga o le faamalieina o togafitiga, e pei o le suiga o le serology antigen, o nisi tagata gasegase e mafai foi ona ausia le lelei mo le togafitiga o le iuga, e taua o le antigen le lelei.